O-Glycosyl Donors
3.4
623
group and into a glycosyl donor by isomerizing the allyl moiety. These compounds can be used
in oligosaccharide synthesis, as outlined in > Scheme 54, for example by coupling 333b with
332 to give trisaccharide 334 (i. e. D 1 D 1 A 1 ). Application of this strategy to four allyl building blocks (B 1→4 ) would lead to four vinyl glycosyl donors (D 1→4 ) and four allyl glycosyl
acceptors (A 1→4 ). Individual glycosylations of each donor with each acceptor will furnish 16
disaccharides (D 1→4 A 1→4 ) (if glycosylations are stereoselective, or 32 disaccharides if conditions are met for 1:1 anomeric selectivity). Next, the disaccharides can be mixed, and removal
⊡ Scheme 55
Preparation of branched trisaccharide libraries
3.4
623
group and into a glycosyl donor by isomerizing the allyl moiety. These compounds can be used
in oligosaccharide synthesis, as outlined in > Scheme 54, for example by coupling 333b with
332 to give trisaccharide 334 (i. e. D 1 D 1 A 1 ). Application of this strategy to four allyl building blocks (B 1→4 ) would lead to four vinyl glycosyl donors (D 1→4 ) and four allyl glycosyl
acceptors (A 1→4 ). Individual glycosylations of each donor with each acceptor will furnish 16
disaccharides (D 1→4 A 1→4 ) (if glycosylations are stereoselective, or 32 disaccharides if conditions are met for 1:1 anomeric selectivity). Next, the disaccharides can be mixed, and removal
⊡ Scheme 55
Preparation of branched trisaccharide libraries