XIV
Table of Contents
10.4 Glycomics and Mass Spectrometry . . . . . . . . . . . . . . . . . . . . 2191
Anne Dell, Jihye Jang-Lee, Poh-Choo Pang, Simon Parry, Mark Sutton-Smith,
Berangere Tissot, Howard R. Morris, Maria Panico, Stuart M. Haslam
10.5 Informatics Tools for Glycomics:
Assisted Interpretation and Annotation of Mass Spectra . . . . . 2219
Alessio Ceroni, Hiren J. Joshi, Kai Maaß,
René Ranzinger, Claus-W. von der Lieth †
11 Biosynthesis and Degradation . . . . . . . . . . . . . . . . . . . . . 2241
11.1 Biosynthesis and Degradation
of Mono-, Oligo-, and Polysaccharides: Introduction . . . . . . . . 2243
Iain B. H. Wilson
11.2 Molecular Basis for the Biosynthesis
of Oligo- and Polysaccharides . . . . . . . . . . . . . . . . . . . . . . . 2265
Iain B. H. Wilson, Christelle Breton, Anne Imberty, Igor Tvaroška
11.3 Polysaccharide Degradation . . . . . . . . . . . . . . . . . . . . . . . . . 2325
Bruce A. Stone, Birte Svensson, Michelle E. Collins, Robert A. Rastall
12 Glycomedicine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2377
12.1 Novel Approaches for Glycodrug Discovery . . . . . . . . . . . . . . 2379
Hirosato Kondo
12.2 Biomedicine of Monosaccharides . . . . . . . . . . . . . . . . . . . . . 2399
Helen M. I. Osborn, Philip G. Evans, Karel Bezouska
12.3 Structure and Function
of Mammalian Carbohydrate-Lectin Interactions . . . . . . . . . . . 2445
Kevin Anderson, David Evers, Kevin G. Rice
12.4 Multivalency in Protein–Carbohydrate Recognition . . . . . . . . . 2483
Laura L. Kiessling, Travis Young, Todd D. Gruber, Kathleen H. Mortell
12.5 Biomedicine of Enkephalin-Derived Glycopeptide Analgesics . . 2525
Robin Polt
12.6 Antitumor and Antimicrobial Glycoconjugates . . . . . . . . . . . . 2545
Thisbe K. Lindhorst
12.7 Glycoside vs. Aglycon:
The Role of Glycosidic Residue in Biological Activity . . . . . . . . 2589
Vladimír Kˇ ren
Table of Contents
10.4 Glycomics and Mass Spectrometry . . . . . . . . . . . . . . . . . . . . 2191
Anne Dell, Jihye Jang-Lee, Poh-Choo Pang, Simon Parry, Mark Sutton-Smith,
Berangere Tissot, Howard R. Morris, Maria Panico, Stuart M. Haslam
10.5 Informatics Tools for Glycomics:
Assisted Interpretation and Annotation of Mass Spectra . . . . . 2219
Alessio Ceroni, Hiren J. Joshi, Kai Maaß,
René Ranzinger, Claus-W. von der Lieth †
11 Biosynthesis and Degradation . . . . . . . . . . . . . . . . . . . . . 2241
11.1 Biosynthesis and Degradation
of Mono-, Oligo-, and Polysaccharides: Introduction . . . . . . . . 2243
Iain B. H. Wilson
11.2 Molecular Basis for the Biosynthesis
of Oligo- and Polysaccharides . . . . . . . . . . . . . . . . . . . . . . . 2265
Iain B. H. Wilson, Christelle Breton, Anne Imberty, Igor Tvaroška
11.3 Polysaccharide Degradation . . . . . . . . . . . . . . . . . . . . . . . . . 2325
Bruce A. Stone, Birte Svensson, Michelle E. Collins, Robert A. Rastall
12 Glycomedicine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2377
12.1 Novel Approaches for Glycodrug Discovery . . . . . . . . . . . . . . 2379
Hirosato Kondo
12.2 Biomedicine of Monosaccharides . . . . . . . . . . . . . . . . . . . . . 2399
Helen M. I. Osborn, Philip G. Evans, Karel Bezouska
12.3 Structure and Function
of Mammalian Carbohydrate-Lectin Interactions . . . . . . . . . . . 2445
Kevin Anderson, David Evers, Kevin G. Rice
12.4 Multivalency in Protein–Carbohydrate Recognition . . . . . . . . . 2483
Laura L. Kiessling, Travis Young, Todd D. Gruber, Kathleen H. Mortell
12.5 Biomedicine of Enkephalin-Derived Glycopeptide Analgesics . . 2525
Robin Polt
12.6 Antitumor and Antimicrobial Glycoconjugates . . . . . . . . . . . . 2545
Thisbe K. Lindhorst
12.7 Glycoside vs. Aglycon:
The Role of Glycosidic Residue in Biological Activity . . . . . . . . 2589
Vladimír Kˇ ren