the cell. With cellular dissolution, the cell contents, including active lysosomal
enzymes, along with the ingested silica, are released into the tissue interstices
(Figure 9.1). Moreover, the freed particles of silica are again phagocytosed by
other macrophages, resulting in a chain of events.
140
Environmental Toxicology
[16:52 26/8/04 P:/CRC PRESS/4365 MING-HO.751 (1670)/4365-009.3d]
Ref: 4365 MING-HO YU Chap-009 Page: 140 135-148
FIGURE 9.1 Suggested mechanism of silicosis.
Source: adapted from Allison, A.C. et al., J. Exp. Med., 124, 141, 1966.
enzymes, along with the ingested silica, are released into the tissue interstices
(Figure 9.1). Moreover, the freed particles of silica are again phagocytosed by
other macrophages, resulting in a chain of events.
140
Environmental Toxicology
[16:52 26/8/04 P:/CRC PRESS/4365 MING-HO.751 (1670)/4365-009.3d]
Ref: 4365 MING-HO YU Chap-009 Page: 140 135-148
FIGURE 9.1 Suggested mechanism of silicosis.
Source: adapted from Allison, A.C. et al., J. Exp. Med., 124, 141, 1966.