J. Bukowska and P. Piotrowski
46
probe modified with the SERS reporter. Low limits of detection obtained in this
approach make it competitive with other viral assays. It is possible to create a multisensitive assay by modifying nanotags for different antigens with different reporter
molecules [141].
3.4.2.2 SERS Probing of Cells and Microorganisms
very high sensitivity of SERS makes it an attractive method to study extremely
complex systems such as single living cells. Compared to normal Raman spectra
Fig. 3.8 Examples of different approaches in dNA SERS sensing: a SERS label bound directly to
the dNA strand [136], b metal nanoparticle bound to dNA single strand while the label is adsorbed
on the surface [134]. (Adapted from Refs. [134, 136] with kind permission of respectively the
American Chemical Society, Copyright 2007 and Royal Society of Chemistry)
46
probe modified with the SERS reporter. Low limits of detection obtained in this
approach make it competitive with other viral assays. It is possible to create a multisensitive assay by modifying nanotags for different antigens with different reporter
molecules [141].
3.4.2.2 SERS Probing of Cells and Microorganisms
very high sensitivity of SERS makes it an attractive method to study extremely
complex systems such as single living cells. Compared to normal Raman spectra
Fig. 3.8 Examples of different approaches in dNA SERS sensing: a SERS label bound directly to
the dNA strand [136], b metal nanoparticle bound to dNA single strand while the label is adsorbed
on the surface [134]. (Adapted from Refs. [134, 136] with kind permission of respectively the
American Chemical Society, Copyright 2007 and Royal Society of Chemistry)