539
Poly(L-glutamic acid) (PLg), 235, 237
Poly(L-lysine) (PLL), 227, 237
Porcine plasma, 222, 229
Pretreatment, 74, 216, 217–219, 224, 279, 287
Primary and secondary metabolites, 253
Principal component analysis (PCA)
loadings, 18–20, 23, 75, 240
scores, 24, 226, 289
Process
adsorption, 32, 38, 39, 40, 44, 224, 403
aggregation, 19, 22, 24, 34, 38, 47, 187,
190, 220–223, 229, 240, 402, 408, 453,
458
association, 90, 224
denaturation, 75, 166, 168, 171, 220–224,
229, 232, 375
fibrillation, 215, 221, 223, 240
folding, 93, 161, 167, 168, 181, 215, 218,
219, 240
oligomerization, 221
unfolding, 75,168, 171, 219–224, 229, 231
Prostate breast, histopathology, 9, 362, 477,
496
Protein structure, 75, 84, 90, 164, 215, 220,
223, 225, 228, 233, 257, 461
Protein
Amyloid, 166, 169, 175, 215, 221,
454–457
Bovine pancreatic trypsin inhibitor (BPtI),
227
Bovine serum albumin, 44, 228, 405
Centrin, 227
Chicken annexin A5, 220
Cytochrome c (cyt c), 40, 221, 222
Epidermal growth factor receptor (EgFR)
Ferricytochrome c (fcyt c), 221
hemoglobin, 221, 222, 509, 521, 525, 531
hepatitis C virus core protein (hCvc-120),
226
human procarboxypeptidase A2 (AdA2h),
221
human serum albumin (hSA), 224, 225,
228
Immunoglobulin (Igg), 224, 226, 402, 512
α-lactalbumin (α-la), 168
β-lactoglobulin (β-lg), 231, 233
Lipoxygenase (LoX), 227
melittin, 227
methionine adenosyltransferase (mAt),
220
myoglobin (mb), 221, 222, 225
ovalbumin, 223, 224
β-purothionin
R
RibonucleaseA(RNase A), 220–222, 463
Sarcoplasmic reticulum Ca2+-AtPase, 220
Streptavidin, 225
Quality, 16, 67, 71, 94, 99, 137, 163, 218,
264, 268, 286, 350
Quantum-chemical calculations, 93,
311–314
Radiation damage, 4, 5, 35, 192
S
Secondary structure, 75, 92, 137, 164–170,
215, 219–225, 228, 229, 240, 424, 453,
458, 525, 528, 530
Sequence of intensity changes, 238
SERS of biological molecules, 47
Silk fiber, 229
Similarity Analysis, 330, 337, 350–352
Spectroscopy
Fluorescence, 138, 169, 173, 220, 228,
264, 284, 312, 316, 357, 388, 391
Infrared, 3, 7–10, 183, 184, 214, 215, 355,
364, 369, 379, 381, 420
mid-IR, 106, 109, 194, 195, 217, 223, 224,
228, 229, 286, 299, 451, 482, 484
Near-IR (NIR), 9, 109, 194–196, 217, 223,
235, 241, 441
Raman imaging, 4, 6–10, 30, 47, 63–76,
97–99, 161, 229, 235–237, 254, 317,
386, 402
Raman optical activity (RoA), 4, 93, 114,
116, 217, 267
vibrational circular dichroism(vCd), 4,
84, 85, 93, 94, 105, 217
Statistical pattern recognition, 75, 287, 443
Surface-Enhanced Raman Spectroscopy
(SERS), 4, 5, 29–51, 106, 138, 216,
254, 261–263, 284, 329, 402–415
T
terpenes, 69, 256
theoretical, 30, 38, 76, 91, 107, 125, 171–174,
274, 350, 436, 486
theoretical calculations, 38, 68, 113, 193, 205
tissue imaging, 8, 9, 291, 310
toxicology, 387
two-dimensional correlation analysis, 74, 216,
226, 237
U
unicellular algae, 310, 313
urea, 85, 220, 230–233
uv-vis spectra, 94, 126
Index
Poly(L-glutamic acid) (PLg), 235, 237
Poly(L-lysine) (PLL), 227, 237
Porcine plasma, 222, 229
Pretreatment, 74, 216, 217–219, 224, 279, 287
Primary and secondary metabolites, 253
Principal component analysis (PCA)
loadings, 18–20, 23, 75, 240
scores, 24, 226, 289
Process
adsorption, 32, 38, 39, 40, 44, 224, 403
aggregation, 19, 22, 24, 34, 38, 47, 187,
190, 220–223, 229, 240, 402, 408, 453,
458
association, 90, 224
denaturation, 75, 166, 168, 171, 220–224,
229, 232, 375
fibrillation, 215, 221, 223, 240
folding, 93, 161, 167, 168, 181, 215, 218,
219, 240
oligomerization, 221
unfolding, 75,168, 171, 219–224, 229, 231
Prostate breast, histopathology, 9, 362, 477,
496
Protein structure, 75, 84, 90, 164, 215, 220,
223, 225, 228, 233, 257, 461
Protein
Amyloid, 166, 169, 175, 215, 221,
454–457
Bovine pancreatic trypsin inhibitor (BPtI),
227
Bovine serum albumin, 44, 228, 405
Centrin, 227
Chicken annexin A5, 220
Cytochrome c (cyt c), 40, 221, 222
Epidermal growth factor receptor (EgFR)
Ferricytochrome c (fcyt c), 221
hemoglobin, 221, 222, 509, 521, 525, 531
hepatitis C virus core protein (hCvc-120),
226
human procarboxypeptidase A2 (AdA2h),
221
human serum albumin (hSA), 224, 225,
228
Immunoglobulin (Igg), 224, 226, 402, 512
α-lactalbumin (α-la), 168
β-lactoglobulin (β-lg), 231, 233
Lipoxygenase (LoX), 227
melittin, 227
methionine adenosyltransferase (mAt),
220
myoglobin (mb), 221, 222, 225
ovalbumin, 223, 224
β-purothionin
R
RibonucleaseA(RNase A), 220–222, 463
Sarcoplasmic reticulum Ca2+-AtPase, 220
Streptavidin, 225
Quality, 16, 67, 71, 94, 99, 137, 163, 218,
264, 268, 286, 350
Quantum-chemical calculations, 93,
311–314
Radiation damage, 4, 5, 35, 192
S
Secondary structure, 75, 92, 137, 164–170,
215, 219–225, 228, 229, 240, 424, 453,
458, 525, 528, 530
Sequence of intensity changes, 238
SERS of biological molecules, 47
Silk fiber, 229
Similarity Analysis, 330, 337, 350–352
Spectroscopy
Fluorescence, 138, 169, 173, 220, 228,
264, 284, 312, 316, 357, 388, 391
Infrared, 3, 7–10, 183, 184, 214, 215, 355,
364, 369, 379, 381, 420
mid-IR, 106, 109, 194, 195, 217, 223, 224,
228, 229, 286, 299, 451, 482, 484
Near-IR (NIR), 9, 109, 194–196, 217, 223,
235, 241, 441
Raman imaging, 4, 6–10, 30, 47, 63–76,
97–99, 161, 229, 235–237, 254, 317,
386, 402
Raman optical activity (RoA), 4, 93, 114,
116, 217, 267
vibrational circular dichroism(vCd), 4,
84, 85, 93, 94, 105, 217
Statistical pattern recognition, 75, 287, 443
Surface-Enhanced Raman Spectroscopy
(SERS), 4, 5, 29–51, 106, 138, 216,
254, 261–263, 284, 329, 402–415
T
terpenes, 69, 256
theoretical, 30, 38, 76, 91, 107, 125, 171–174,
274, 350, 436, 486
theoretical calculations, 38, 68, 113, 193, 205
tissue imaging, 8, 9, 291, 310
toxicology, 387
two-dimensional correlation analysis, 74, 216,
226, 237
U
unicellular algae, 310, 313
urea, 85, 220, 230–233
uv-vis spectra, 94, 126
Index