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123. Beljebbar A, Amharref N, Leveques A et al (2008) modeling and quantifying biochemical
changes in C6 tumor gliomas by Fourier transform infrared imaging. Anal Chem 80:8406–
8415
124. Sobottka SB, geiger Kd, Salzer R et al (2009) Suitability of infrared spectroscopic imaging as an intraoperative tool in cerebral glioma surgery. Anal Bioanal Chem 393:187–195
125. Beljebbar A, dukic S, Amharref N et al (2010) Screening of biochemical/histological changes associated to C6 glioma tumor development by FtIR/PCA imaging. Analyst 135:1090–
1097
126. Choo LP, Wetzel DL, Halliday WC et al (1996) In situ characterization of β-amyloid in
Alzheimer’s diseased tissue by synchrotron Fourier transform infrared microspectrometry.
Biophys J 71:1672–1679
127. miller Lm, Wang Q, telivala tP et al (2006) Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with β-amyloid deposits in
Alzheimer’s disease. J Struct Biol 155:30–37
128. Leskovjan AC, Lanzirotti A, miller Lm (2009) Amyloid plaques in PSAPP mice bind less
metal than plaques in human Azheimer’s disease. NeuroImage 47:1215–1220
129. Leskovjan AC, Kretlow A, miller Lm (2010) Fourier transform infrared imaging showing
reduced unsaturated lipid content in the hippocampus of a mouse model of Alzheimer’s
disease. Anal Chem 82:2711–2716
130. gallant m, Rak m, Szeghalmi A et al (2006) Focally elevated creatine detected in amyloid
precursor protein (APP) transgenic mice and Alzheimer disease brain tissue. J Biol Chem
281:5–8
131. Kuzyk A, Kastyak m, Agrawal v et al (2010) Association among amyloid plaque, lipid, and
creatine in hippocampus of tgCRNd8 mouse model for Alzheimer disease. J Biol Chem
285:31202–31207
132. Rak M, Del Bigio MR, Mai S et al (2007) Dense-core and diffuse Aβ plaques in TgCRND8
mice studied with synchrotron FtIR microspectroscopy. Biopolymers 87:207–217
133. Kastyak-Ibrahim mZ, Nasse mJ, Rak m et al (2012) Biochemical label-free tissue imaging with subcellular-resolution synchrotron FtIR with focal array detector. NeuroImage
60:376–383
134. Chwiej J, dulinska J, Janeczko K et al (2010) Synchrotron FtIR micro-spectroscopy study
of the rat hippocampal formation after pilocarpine-evoked seizures. J Chem Neuroanat
40:140–147
135. dulinska J, Setkowicz Z, Janeczko K et al (2012) Synchrotron radiation Fourier-transform
infrared and Raman microspectroscopy study showing an increased frequency of creatine
inclusions in the rat hippocampal formation following pilocarpine-evoked seizures. Anal
Bioanal Chem 402:2267–2274
136. Kastyak mZ, Szczerbowska-Boruchowska m, Adamek d et al (2010) Pigmented creatine
deposits in amyotrophic lateral sclerosis nervous system tissues identified by synchrotron
Fourier transform infrared microspectroscopy and X-ray fluorescence spectromicroscopy.
Neuroscience 166:1119–1128
137. Szczebowska-Boruchowska m, dumas P, Kastyak mZ et al (2007) Biomolecular investigation of human substantia nigra in Parkinson’s disease by synchrotron radiation Fourier
transform infrared microspectroscopy. Arch Biochem Biophys 459:241–248
138. Choo LP, Jackson m, halliday WC (1993) Infrared spectroscopic characterization of
multiple sclerosis plaques in the human central nervous system. Biochim Biophys Acta
1182:333–337
139. Levine Sm, Wetzel dL (1998) Chemical analysis of multiple lesions by Ft-IR microspectroscopy. Free Rad Biol med 25:33–41
140. heraud P, Caine S, Campanale N et al (2010) Early detection of the chemical changes
occurring during the induction and prevention of autoimmune-mediated demyelination detected by Ft-IR imaging. NeuroImage 49:1180–1189
K. malek et al.
123. Beljebbar A, Amharref N, Leveques A et al (2008) modeling and quantifying biochemical
changes in C6 tumor gliomas by Fourier transform infrared imaging. Anal Chem 80:8406–
8415
124. Sobottka SB, geiger Kd, Salzer R et al (2009) Suitability of infrared spectroscopic imaging as an intraoperative tool in cerebral glioma surgery. Anal Bioanal Chem 393:187–195
125. Beljebbar A, dukic S, Amharref N et al (2010) Screening of biochemical/histological changes associated to C6 glioma tumor development by FtIR/PCA imaging. Analyst 135:1090–
1097
126. Choo LP, Wetzel DL, Halliday WC et al (1996) In situ characterization of β-amyloid in
Alzheimer’s diseased tissue by synchrotron Fourier transform infrared microspectrometry.
Biophys J 71:1672–1679
127. miller Lm, Wang Q, telivala tP et al (2006) Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with β-amyloid deposits in
Alzheimer’s disease. J Struct Biol 155:30–37
128. Leskovjan AC, Lanzirotti A, miller Lm (2009) Amyloid plaques in PSAPP mice bind less
metal than plaques in human Azheimer’s disease. NeuroImage 47:1215–1220
129. Leskovjan AC, Kretlow A, miller Lm (2010) Fourier transform infrared imaging showing
reduced unsaturated lipid content in the hippocampus of a mouse model of Alzheimer’s
disease. Anal Chem 82:2711–2716
130. gallant m, Rak m, Szeghalmi A et al (2006) Focally elevated creatine detected in amyloid
precursor protein (APP) transgenic mice and Alzheimer disease brain tissue. J Biol Chem
281:5–8
131. Kuzyk A, Kastyak m, Agrawal v et al (2010) Association among amyloid plaque, lipid, and
creatine in hippocampus of tgCRNd8 mouse model for Alzheimer disease. J Biol Chem
285:31202–31207
132. Rak M, Del Bigio MR, Mai S et al (2007) Dense-core and diffuse Aβ plaques in TgCRND8
mice studied with synchrotron FtIR microspectroscopy. Biopolymers 87:207–217
133. Kastyak-Ibrahim mZ, Nasse mJ, Rak m et al (2012) Biochemical label-free tissue imaging with subcellular-resolution synchrotron FtIR with focal array detector. NeuroImage
60:376–383
134. Chwiej J, dulinska J, Janeczko K et al (2010) Synchrotron FtIR micro-spectroscopy study
of the rat hippocampal formation after pilocarpine-evoked seizures. J Chem Neuroanat
40:140–147
135. dulinska J, Setkowicz Z, Janeczko K et al (2012) Synchrotron radiation Fourier-transform
infrared and Raman microspectroscopy study showing an increased frequency of creatine
inclusions in the rat hippocampal formation following pilocarpine-evoked seizures. Anal
Bioanal Chem 402:2267–2274
136. Kastyak mZ, Szczerbowska-Boruchowska m, Adamek d et al (2010) Pigmented creatine
deposits in amyotrophic lateral sclerosis nervous system tissues identified by synchrotron
Fourier transform infrared microspectroscopy and X-ray fluorescence spectromicroscopy.
Neuroscience 166:1119–1128
137. Szczebowska-Boruchowska m, dumas P, Kastyak mZ et al (2007) Biomolecular investigation of human substantia nigra in Parkinson’s disease by synchrotron radiation Fourier
transform infrared microspectroscopy. Arch Biochem Biophys 459:241–248
138. Choo LP, Jackson m, halliday WC (1993) Infrared spectroscopic characterization of
multiple sclerosis plaques in the human central nervous system. Biochim Biophys Acta
1182:333–337
139. Levine Sm, Wetzel dL (1998) Chemical analysis of multiple lesions by Ft-IR microspectroscopy. Free Rad Biol med 25:33–41
140. heraud P, Caine S, Campanale N et al (2010) Early detection of the chemical changes
occurring during the induction and prevention of autoimmune-mediated demyelination detected by Ft-IR imaging. NeuroImage 49:1180–1189