444
5 Laser Specklometer, Speckle-Optical Diagnostics and Laser …
Thus, summarizing all of the studies, we can say that the methods of coherent
optics can be successfully used in neurological practice. The developed methods
allow us to register in patients with lesions of the peripheral nervous system of
various etiologies the microhemodynamic processes of denervation and changes in
muscle activity with the identification of local hypertonus, and objectively assess the
dynamics of the patient’s condition and treatment effectiveness.
As follows from the data presented, the use of coherent light for the treatment of
diseases of the peripheral nervous system is especially effective when it is exposed on
the internal environment. The absence of adverse effects from the use of intravenous
laser blood irradiation in the treatment of a number of lesions of the peripheral
nervous system, which are investigated in our study, testifies the feasibility of its
wider adoption in neurological practice. However, it is necessary to bear in mind that
at extending the range of application of ILBI in neurology it seems to be necessary to
study the remote effects of therapeutic intervention, as well as to analyze its effects
on neuromotor apparatus, the state of endothelial cells and other pathogenetic links
of diseases of the nervous system [177, 178].
5.12 Speckle-Optical Diagnostics of Muscle Activity
and Microhemodynamics of Human Skin in Patients
with Diseases of Peripheral Nervous System
Below, there are some of the results of medical studies carried out using the laser
specklometer. The purpose of the investigation is to study the functional disorder of
the neuromuscular system and skin microhemodynamics in ischemic and traumatic
lesions of peripheral nerves, as well as muscular-tonic syndromes of neurological
manifestations of lumbar degenerative disk disease through the development of new
methods of optical speckle evaluation and possible use of intravenous laser blood
irradiation in the treatment of damage to peripheral nerves and cerebral ischemia.
The clinical trials were conducted in 116 patients (95 patients with neurologic
manifestations of lumbar degenerative disk disease, 21—with compressive–ischemic
neuropathies). The control group consisted of 30 healthy individuals.
Experimental studies were performed on 144 pubertal rabbits of both sexes.
Speckle-optical indicators of skin microhemodynamics (MHD) and functional
activity of muscles were studied under intravenous hexenal narcosis after modeling
ischemia of a hind limb (ISH) (39 animals), traumatic injuries of sciatic nerve with
further neurography (40 rabbits) and local ischemia of brain (LIB) (28 animals).
Rabbits (37) with the simulation of a similar pathology served as controls. The
rabbits had not been treated with intravenous laser blood irradiation. The biochemical
parameters of the calf muscles were studied at rest condition and at their passive
contraction.
The speckle-optical estimation of functional activity of gastrocnemius muscles
of a rabbit showed that the spectrum power (SP) reduced by 50% in 7 days after
5 Laser Specklometer, Speckle-Optical Diagnostics and Laser …
Thus, summarizing all of the studies, we can say that the methods of coherent
optics can be successfully used in neurological practice. The developed methods
allow us to register in patients with lesions of the peripheral nervous system of
various etiologies the microhemodynamic processes of denervation and changes in
muscle activity with the identification of local hypertonus, and objectively assess the
dynamics of the patient’s condition and treatment effectiveness.
As follows from the data presented, the use of coherent light for the treatment of
diseases of the peripheral nervous system is especially effective when it is exposed on
the internal environment. The absence of adverse effects from the use of intravenous
laser blood irradiation in the treatment of a number of lesions of the peripheral
nervous system, which are investigated in our study, testifies the feasibility of its
wider adoption in neurological practice. However, it is necessary to bear in mind that
at extending the range of application of ILBI in neurology it seems to be necessary to
study the remote effects of therapeutic intervention, as well as to analyze its effects
on neuromotor apparatus, the state of endothelial cells and other pathogenetic links
of diseases of the nervous system [177, 178].
5.12 Speckle-Optical Diagnostics of Muscle Activity
and Microhemodynamics of Human Skin in Patients
with Diseases of Peripheral Nervous System
Below, there are some of the results of medical studies carried out using the laser
specklometer. The purpose of the investigation is to study the functional disorder of
the neuromuscular system and skin microhemodynamics in ischemic and traumatic
lesions of peripheral nerves, as well as muscular-tonic syndromes of neurological
manifestations of lumbar degenerative disk disease through the development of new
methods of optical speckle evaluation and possible use of intravenous laser blood
irradiation in the treatment of damage to peripheral nerves and cerebral ischemia.
The clinical trials were conducted in 116 patients (95 patients with neurologic
manifestations of lumbar degenerative disk disease, 21—with compressive–ischemic
neuropathies). The control group consisted of 30 healthy individuals.
Experimental studies were performed on 144 pubertal rabbits of both sexes.
Speckle-optical indicators of skin microhemodynamics (MHD) and functional
activity of muscles were studied under intravenous hexenal narcosis after modeling
ischemia of a hind limb (ISH) (39 animals), traumatic injuries of sciatic nerve with
further neurography (40 rabbits) and local ischemia of brain (LIB) (28 animals).
Rabbits (37) with the simulation of a similar pathology served as controls. The
rabbits had not been treated with intravenous laser blood irradiation. The biochemical
parameters of the calf muscles were studied at rest condition and at their passive
contraction.
The speckle-optical estimation of functional activity of gastrocnemius muscles
of a rabbit showed that the spectrum power (SP) reduced by 50% in 7 days after