2 Bio-microelectromechanical Systems (BioMEMS) …
31
Table 2.1
(continued)
BioMEMS platform
Main components
Fabrication strategy Mechanisms of
operation
Detected analyte
Specifics
References
Microfluidic
colorimetric biosensor
using AuNPs
aggregation and
smartphone imaging
• AuNPs
• Microfluidic chip
• 2 serpentine mixing
channels
• Separation chamber
• Detection chamber
Solidworks was used
to create the design
of the chip. It was
3D printed and
underwent surface
plasma bonding.
Surplus support
material was
removed while the
PDMS prepolymer
attached to it. The
PDMS replica was
peeled off and joined
to the glass slide
The MNPs and the PSs
reacted with the target
bacteria in the first
mixing channel. In the
second step, AuNPs
and the crosslinking
agents reacted with the
catalysate. This
interaction was
responsible for the
color change
• E. coli O157:H7
The addition of
AuNPs effectively
increased the signal
indication. Also,
the chip’s mixing
productivity
impacted the
detection time and
sensitivity for
foodborne
pathogens
Zheng et al.
(2019)
(continued)