14 Oscillations, Rhythms and Synchronized Time Bases …
237
Advantages proposed for systems displaying chaos include innovation, the preservation of diversity, the prevention of entrainment and the dissipation of disturbance
[84]. Controlled chaos may provide for flexible mechanisms for switching from one
periodic orbit to another [83]. Chaotic dynamics has recently been detected in mitochondrial oxidative metabolism under stress when network stability is compromised
at the ‘edge’ between fully functional and pathological behaviour [65, 66].
14.2 General Conclusions
Studies of ultradian oscillatory phenomena as ‘the dynamic signatures of life’ [163],
not only in lower eukaryotes, but also in mammals [98, 132], and of declining capacities during aging [157], are playing a burgeoning part in current research [20, 21,
76, 77], as well as future diagnostic and medical practice [134, 158–161].
Acknowledgements DL would like to thank all the students and coworkers involved for permission
to publish their data, and especially Dr. MR Roussel, for a figure and his interpretation of those
data. Two referees kindly provided important information.
This chapter is dedicated to the memory of Robert M. May, the complex systems pioneer who
died on 28 April 2020.
References
1. C. Amariei, R. Machné, K. Sasidharan, W. Gottstein, M. Tomita, T. Soga, D. Lloyd, D.B.
Murray, The dynamics of cellular energetics during continuous yeast culture. Conf. Proc.
IEEE Eng. Med. Biol. Soc. 2013, 2708–2711 (2013)
2. C. Amariei, R. Machné, V. Stoic, T. Soga, M. Tomita, D. Lloyd, D.B. Murray, Time resolved
DNA occupancy dynamics during the respiratory oscillation uncover a global reset point in
the yeast growth program. Microb. Cell 1(9), 279–288 (2014)
3. H.C. Andersen, The Nightingale, in The Complete Hans Christian Andersen Fairy Tales,
trans. J. Hersholt. Canterbury Classics (G Books, Baker and Taylor, San Diego, CA, 1843),
pp. 159–164
4. A.Z. Andersen, A.K. Poulsen, J.C. Brasen, L.F. Olsen, On-line measurements of oscillating
mitochondrial membrane potential in glucose-fermenting Saccharomyces cerevisiae. Yeast
24, 731–739 (2007)
5. M.A. Aon, S. Cortassa, K.M. Lemar, A. Hayes, D. Lloyd, Single and cell population
respiratory oscillations in yeast: a 2-photon study. FEBS Lett. 58, 6–14 (2007)
6. M.A. Aon, M.R. Roussel, S. Cortassa, B. O’Rourke, D.B. Murray, M. Beckmann, D. Lloyd,
The scale-free dynamics of eukaryotic cells. PLoS ONE 3(11), e3624 (2008)
7. C.L. Bashford, R.K. Poole, D. Lloyd, B. Chance, Oscillations of redox state in synchronized
dividing cultures of Acanthamoeba castellanii and Schizosaccharomyces pombe. Biophys. J.
29, 1–11 (1980)
8. B.L. Baumgartner, R. O’Laughlin, M. Jin, L.S. Tsimring, N. Hao, J. Hasty, Flavin-based
metabolic cycles are integral features of growth and division in single cells. Sci. Rep. 8(1),
18045 (2018)
237
Advantages proposed for systems displaying chaos include innovation, the preservation of diversity, the prevention of entrainment and the dissipation of disturbance
[84]. Controlled chaos may provide for flexible mechanisms for switching from one
periodic orbit to another [83]. Chaotic dynamics has recently been detected in mitochondrial oxidative metabolism under stress when network stability is compromised
at the ‘edge’ between fully functional and pathological behaviour [65, 66].
14.2 General Conclusions
Studies of ultradian oscillatory phenomena as ‘the dynamic signatures of life’ [163],
not only in lower eukaryotes, but also in mammals [98, 132], and of declining capacities during aging [157], are playing a burgeoning part in current research [20, 21,
76, 77], as well as future diagnostic and medical practice [134, 158–161].
Acknowledgements DL would like to thank all the students and coworkers involved for permission
to publish their data, and especially Dr. MR Roussel, for a figure and his interpretation of those
data. Two referees kindly provided important information.
This chapter is dedicated to the memory of Robert M. May, the complex systems pioneer who
died on 28 April 2020.
References
1. C. Amariei, R. Machné, K. Sasidharan, W. Gottstein, M. Tomita, T. Soga, D. Lloyd, D.B.
Murray, The dynamics of cellular energetics during continuous yeast culture. Conf. Proc.
IEEE Eng. Med. Biol. Soc. 2013, 2708–2711 (2013)
2. C. Amariei, R. Machné, V. Stoic, T. Soga, M. Tomita, D. Lloyd, D.B. Murray, Time resolved
DNA occupancy dynamics during the respiratory oscillation uncover a global reset point in
the yeast growth program. Microb. Cell 1(9), 279–288 (2014)
3. H.C. Andersen, The Nightingale, in The Complete Hans Christian Andersen Fairy Tales,
trans. J. Hersholt. Canterbury Classics (G Books, Baker and Taylor, San Diego, CA, 1843),
pp. 159–164
4. A.Z. Andersen, A.K. Poulsen, J.C. Brasen, L.F. Olsen, On-line measurements of oscillating
mitochondrial membrane potential in glucose-fermenting Saccharomyces cerevisiae. Yeast
24, 731–739 (2007)
5. M.A. Aon, S. Cortassa, K.M. Lemar, A. Hayes, D. Lloyd, Single and cell population
respiratory oscillations in yeast: a 2-photon study. FEBS Lett. 58, 6–14 (2007)
6. M.A. Aon, M.R. Roussel, S. Cortassa, B. O’Rourke, D.B. Murray, M. Beckmann, D. Lloyd,
The scale-free dynamics of eukaryotic cells. PLoS ONE 3(11), e3624 (2008)
7. C.L. Bashford, R.K. Poole, D. Lloyd, B. Chance, Oscillations of redox state in synchronized
dividing cultures of Acanthamoeba castellanii and Schizosaccharomyces pombe. Biophys. J.
29, 1–11 (1980)
8. B.L. Baumgartner, R. O’Laughlin, M. Jin, L.S. Tsimring, N. Hao, J. Hasty, Flavin-based
metabolic cycles are integral features of growth and division in single cells. Sci. Rep. 8(1),
18045 (2018)