294
A. S. Shinde et al.
132. Wijesinghe D, Arachchige MC, Lu A, Reshetnyak YK, Andreev OA (2013) pH dependent
transfer of nano-pores into membrane of cancer cells to induce apoptosis. Sci Rep 3:3560
133. Hladky SB, Haydon DA (1972) Ion transfer across lipid membranes in the presence of gramicidin A: I. Studies of the unit conductance channel. Biochim Biophys Acta (BBA)-Biomembr
274:294–312
134. Yao L, Daniels J, Moshnikova A, Kuznetsov S, Ahmed A, Engelman DM, Reshetnyak YK,
Andreev OA (2013) pHLIP peptide targets nanogold particles to tumors. Proc Natl Acad Sci
110:465–470. https://doi.org/10.1073/pnas.1219665110
135. Davies A, Lewis DJ, Watson SP, Thomas SG, Pikramenou Z (2012) pH-controlled delivery of
luminescent europium coated nanoparticles into platelets. Proc Natl Acad Sci 109:1862–1867.
https://doi.org/10.1073/pnas.1112132109/-/DCSupplemental
136. Han L, Ma H, Guo Y, Kuang Y, He X, Jiang C (2013) PH-controlled delivery of nanoparticles
into tumor cells. Adv Healthc Mater 2:1435–1439. https://doi.org/10.1002/adhm.201300013
137. Zhao Z, Meng H, Wang N, Donovan MJ, Fu T, You M, Chen Z, Zhang X, Tan W (2013) A
controlled-release nanocarrier with extracellular pH value driven tumor targeting and translocation for drug delivery. Angew Chemie Int Ed 52:7487–7491. https://doi.org/10.1002/anie.
201302557
138. Shinde P, Kumar A, Illath K, Dey K, Mohan L, Barik TK, Rad J, Nagai M, Santra TS (2020)
Physical approaches for drug delivery-an overview. Elsevier
139. Shinde P, Mohan L, Maddi A, Dey K, Chang H-Y, Nagai M, Santra TS (2018) Current and
emerging trends of single cell technology. Int J Mol Sci 19:3143
140. Tseng F, Santra T (2016) Essentials of single-cell analysis. Springer, Berlin Heidelberg
141. Santra TS, Tseng F-G (2020) Handbook of single cell technologies. Springer Nature Publisher
142. Kar S, Mohan L, Dey K, Shinde P, Chang H-Y, Nagai M, Santra TS (2018) Single-cell
electroporation: current trends, applications and future prospects. J Micromech Microeng
28:123002
143. Santra TS, Chiou PY, Wu T-H (2016) Optical MEMS for chemical analysis and biomedicine.
In: Photothermal microfluidics. The Institute of Engineering and Technology (IET), USA Inc
144. Kumar A, Mohan L, Shinde P, Chang H-Y, Nagai M, Santra TS (2018) Mechanoporation:
towards single cell approaches. In: Handbook of single cell technologies. Springer
145. Santra TS, Chen S-C, Chang C-J, Chen T-J, Wang P-C, Tseng F-G (2012) Delivery of
molecules into cells using localized single cell electroporation by ITO micro-electrode based
transparent chip. Biomed Microdevices 14:811–817
146. Santra TS, Chang HY, Wang PC, Tseng FG (2014) Impact of pulse duration on localized singlecell nano-electroporation. Analyst 139:6249–6258. https://doi.org/10.1039/c4an01050g
147. Dhakal K, Batabyal S, Wright W, Kim YT, Mohanty S (2015) Optical delivery of multiple
opsin-encoding genes leads to targeted expression and white-light activation. Light Sci Appl
4:e352–e352
148. Santra TS, Kar S, Chen T-C, Chen C-W, Chang H-W, Lee M-C, Tseng F-G (2020) Nearinfrared nanosecond-pulsed laser-activated high efficient intracellular delivery mediated by
nano-corrugated mushroom-shaped gold-coated polystyrene nanoparticles. RSC Nanoscale
12:12057–12067. https://doi.org/10.1039/D0NR01792B
149. Kar S, Shinde P, Nagai M, Santra TS (2020) Optical manipulation of cells. In: Microfluidics
and bio-mems: devices and applications. Jenny Stanford Publisher Pte. Ltd
150. Illath K, Narasimahan AK, Nagai M, Wankhar S, Santra TS (2020) Microfluidic based
metallic nanoparticle synthesis and applications. In: Microfluidics and bio-mems: devices
and applications. Jenny Stanford Publisher Pte. Ltd
151. Kumar A, Shinde P, Mohan L, Mhapatra PS, Santra TS (2020) Microfluidic technologies for
cell manipulation, therapeutics and analysis. In: Microfluidics and bio-mems: devices and
applications. Jenny Stanford Publisher Pte. Ltd
152. Jiskoot W, Van Schie RMF, Carstens MG, Schellekens H (2009) Immunological risk of
injectable drug delivery systems. Pharm Res 26:1303–1314
153. Thiele L, Rothen-Rutishauser B, Jilek S, Wunderli-Allenspach H, Merkle HP, Walter E
(2001) Evaluation of particle uptake in human blood monocyte-derived cells in vitro. Does
A. S. Shinde et al.
132. Wijesinghe D, Arachchige MC, Lu A, Reshetnyak YK, Andreev OA (2013) pH dependent
transfer of nano-pores into membrane of cancer cells to induce apoptosis. Sci Rep 3:3560
133. Hladky SB, Haydon DA (1972) Ion transfer across lipid membranes in the presence of gramicidin A: I. Studies of the unit conductance channel. Biochim Biophys Acta (BBA)-Biomembr
274:294–312
134. Yao L, Daniels J, Moshnikova A, Kuznetsov S, Ahmed A, Engelman DM, Reshetnyak YK,
Andreev OA (2013) pHLIP peptide targets nanogold particles to tumors. Proc Natl Acad Sci
110:465–470. https://doi.org/10.1073/pnas.1219665110
135. Davies A, Lewis DJ, Watson SP, Thomas SG, Pikramenou Z (2012) pH-controlled delivery of
luminescent europium coated nanoparticles into platelets. Proc Natl Acad Sci 109:1862–1867.
https://doi.org/10.1073/pnas.1112132109/-/DCSupplemental
136. Han L, Ma H, Guo Y, Kuang Y, He X, Jiang C (2013) PH-controlled delivery of nanoparticles
into tumor cells. Adv Healthc Mater 2:1435–1439. https://doi.org/10.1002/adhm.201300013
137. Zhao Z, Meng H, Wang N, Donovan MJ, Fu T, You M, Chen Z, Zhang X, Tan W (2013) A
controlled-release nanocarrier with extracellular pH value driven tumor targeting and translocation for drug delivery. Angew Chemie Int Ed 52:7487–7491. https://doi.org/10.1002/anie.
201302557
138. Shinde P, Kumar A, Illath K, Dey K, Mohan L, Barik TK, Rad J, Nagai M, Santra TS (2020)
Physical approaches for drug delivery-an overview. Elsevier
139. Shinde P, Mohan L, Maddi A, Dey K, Chang H-Y, Nagai M, Santra TS (2018) Current and
emerging trends of single cell technology. Int J Mol Sci 19:3143
140. Tseng F, Santra T (2016) Essentials of single-cell analysis. Springer, Berlin Heidelberg
141. Santra TS, Tseng F-G (2020) Handbook of single cell technologies. Springer Nature Publisher
142. Kar S, Mohan L, Dey K, Shinde P, Chang H-Y, Nagai M, Santra TS (2018) Single-cell
electroporation: current trends, applications and future prospects. J Micromech Microeng
28:123002
143. Santra TS, Chiou PY, Wu T-H (2016) Optical MEMS for chemical analysis and biomedicine.
In: Photothermal microfluidics. The Institute of Engineering and Technology (IET), USA Inc
144. Kumar A, Mohan L, Shinde P, Chang H-Y, Nagai M, Santra TS (2018) Mechanoporation:
towards single cell approaches. In: Handbook of single cell technologies. Springer
145. Santra TS, Chen S-C, Chang C-J, Chen T-J, Wang P-C, Tseng F-G (2012) Delivery of
molecules into cells using localized single cell electroporation by ITO micro-electrode based
transparent chip. Biomed Microdevices 14:811–817
146. Santra TS, Chang HY, Wang PC, Tseng FG (2014) Impact of pulse duration on localized singlecell nano-electroporation. Analyst 139:6249–6258. https://doi.org/10.1039/c4an01050g
147. Dhakal K, Batabyal S, Wright W, Kim YT, Mohanty S (2015) Optical delivery of multiple
opsin-encoding genes leads to targeted expression and white-light activation. Light Sci Appl
4:e352–e352
148. Santra TS, Kar S, Chen T-C, Chen C-W, Chang H-W, Lee M-C, Tseng F-G (2020) Nearinfrared nanosecond-pulsed laser-activated high efficient intracellular delivery mediated by
nano-corrugated mushroom-shaped gold-coated polystyrene nanoparticles. RSC Nanoscale
12:12057–12067. https://doi.org/10.1039/D0NR01792B
149. Kar S, Shinde P, Nagai M, Santra TS (2020) Optical manipulation of cells. In: Microfluidics
and bio-mems: devices and applications. Jenny Stanford Publisher Pte. Ltd
150. Illath K, Narasimahan AK, Nagai M, Wankhar S, Santra TS (2020) Microfluidic based
metallic nanoparticle synthesis and applications. In: Microfluidics and bio-mems: devices
and applications. Jenny Stanford Publisher Pte. Ltd
151. Kumar A, Shinde P, Mohan L, Mhapatra PS, Santra TS (2020) Microfluidic technologies for
cell manipulation, therapeutics and analysis. In: Microfluidics and bio-mems: devices and
applications. Jenny Stanford Publisher Pte. Ltd
152. Jiskoot W, Van Schie RMF, Carstens MG, Schellekens H (2009) Immunological risk of
injectable drug delivery systems. Pharm Res 26:1303–1314
153. Thiele L, Rothen-Rutishauser B, Jilek S, Wunderli-Allenspach H, Merkle HP, Walter E
(2001) Evaluation of particle uptake in human blood monocyte-derived cells in vitro. Does