Nanomaterials in Medicine
209
9. Mazzola L (2003) Commercializing nanotechnology. Nat Biotechnol 21:1137–1143. https://
doi.org/10.1038/nbt1003-1137
10. Zhang B, Yan W, Zhu Y, Yang W, Le W, Chen B, Zhu R, Cheng L (2018) Nanomaterials
in Neural-Stem-Cell-mediated regenerative medicine: imaging and treatment of neurological
diseases. Adv Mater 30:1–23. https://doi.org/10.1002/adma.201705694
11. Zhao Y, Sultan D, Detering L, Cho S, Sun G, Pierce R, Wooley KL, Liu Y (2014) Copper-64alloyed gold nanoparticles for cancer imaging: Improved radiolabel stability and diagnostic
accuracy. Angew Chemie Int Ed. https://doi.org/10.1002/anie.201308494
12. Skalska J, Frontczak-Baniewicz M, Stru˙ zy´ nska L (2015) Synaptic degeneration in rat brain
after prolonged oral exposure to silver nanoparticles. Neurotoxicol 46:145–154. https://doi.
org/10.1016/j.neuro.2014.11.002
13. Rosen AB, Schuldt AJT, Kelly DJ, Potapova IA, Doronin SV., Brink PR, Gaudette GR,
Cohen IS (2007) Quantitative analysis of hMSC-seeded biological scaffolds using quantum
dot nanoparticles. In: Bioengineering, Proceedings of the Northeast Conference
14. Sanchez DNR, Bertanha M, Fernandes TD, Resende LA de L, Deffune E, Amorim RM (2017)
Effects of canine and murine mesenchymal stromal cell transplantation on peripheral nerve
regeneration. Int J Stem Cells. https://doi.org/10.15283/ijsc16037
15. Agarwal R, Domowicz MS, Schwartz NB, Henry J, Medintz I, Delehanty JB, Stewart MH,
Susumu K, Huston AL, Deschamps JR, Dawson PE, Palomo V, Dawson G (2015) Delivery
and tracking of quantum dot peptide bioconjugates in an intact developing avian brain. ACS
Chem Neurosci. https://doi.org/10.1021/acschemneuro.5b00022
16. Singer M, Deutschman CS, Seymour C, Shankar-Hari M, Annane D, Bauer M, Bellomo R,
Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS,
Opal SM, Rubenfeld GD, Der Poll T, Vincent JL, Angus DC (2016) The third international
consensus definitions for sepsis and septic shock (sepsis-3). JAMA J Am Med, Assoc
17. Yuk SA, Sanchez-Rodriguez DA, Tsifansky MD, Yeo Y (2018) Recent advances in
nanomedicine for sepsis treatment. Ther Deliv 9(6):435–450
18. Ashton S, Song YH, Nolan J, Cadogan E, Murray J, Odedra R, Foster J, Hall PA, Low S,
Taylor P, Ellston R, Polanska UM, Wilson J, Howes C, Smith A, Goodwin RJA, Swales JG,
Strittmatter N, Takáts Z, Nilsson A, Andren P, Trueman D, Walker M, Reimer CL, Troiano G,
Parsons D, De Witt D, Ashford M, Hrkach J, Zale S, Jewsbury PJ, Barry ST (2016) Aurora
kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo. Sci Transl
Med. https://doi.org/10.1126/scitranslmed.aad2355
19. Ward NS, Levy MM (2017) Sepsis: definitions, Pathophysiology and the challenge of bedside
management. Humana Press, Cham (Switzerland)
20. Sondi I, Salopek-Sondi B (2004) Silver nanoparticles as antimicrobial agent: a case study on
E. coli as a model for Gram-negative bacteria. J Colloid Interface Sci. https://doi.org/10.1016/
j.jcis.2004.02.012
21. Le Ouay B, Stellacci F (2015) Antibacterial activity of silver nanoparticles: a surface science
insight. Nano Today
22. Pal S, Tak YK, Song JM (2007) Does the antibacterial activity of silver nanoparticles depend
on the shape of the nanoparticle? A study of the gram-negative bacterium Escherichia coli.
Appl Environ Microbiol. https://doi.org/10.1128/AEM.02218-06
23. Lansdown ABG (2006) Silver in health care: antimicrobial effects and safety in use. Curr Probl
Dermatol 33:17–34
24. Lam SJ, O’Brien-Simpson NM, Pantarat N, Sulistio A, Wong EHH, Chen YY, Lenzo JC, Holden
JA, Blencowe A, Reynolds EC, Qiao GG (2016) Combating multidrug-resistant gram-negative
bacteria with structurally nanoengineered antimicrobial peptide polymers. Nat Microbiol.
https://doi.org/10.1038/nmicrobiol.2016.162
25. Gessner I, Neundorf I (2020) Nanoparticles Modified with cell-penetrating peptides: conjugation mechanisms, physicochemical properties, and application in cancer diagnosis and therapy.
Int J Mol Sci 21:1–21. https://doi.org/10.3390/ijms21072536
26. Silva S, Almeida AJ, Vale N (2019) Combination of cell-penetrating peptides with nanoparticles
for therapeutic application: a review. Biomol
209
9. Mazzola L (2003) Commercializing nanotechnology. Nat Biotechnol 21:1137–1143. https://
doi.org/10.1038/nbt1003-1137
10. Zhang B, Yan W, Zhu Y, Yang W, Le W, Chen B, Zhu R, Cheng L (2018) Nanomaterials
in Neural-Stem-Cell-mediated regenerative medicine: imaging and treatment of neurological
diseases. Adv Mater 30:1–23. https://doi.org/10.1002/adma.201705694
11. Zhao Y, Sultan D, Detering L, Cho S, Sun G, Pierce R, Wooley KL, Liu Y (2014) Copper-64alloyed gold nanoparticles for cancer imaging: Improved radiolabel stability and diagnostic
accuracy. Angew Chemie Int Ed. https://doi.org/10.1002/anie.201308494
12. Skalska J, Frontczak-Baniewicz M, Stru˙ zy´ nska L (2015) Synaptic degeneration in rat brain
after prolonged oral exposure to silver nanoparticles. Neurotoxicol 46:145–154. https://doi.
org/10.1016/j.neuro.2014.11.002
13. Rosen AB, Schuldt AJT, Kelly DJ, Potapova IA, Doronin SV., Brink PR, Gaudette GR,
Cohen IS (2007) Quantitative analysis of hMSC-seeded biological scaffolds using quantum
dot nanoparticles. In: Bioengineering, Proceedings of the Northeast Conference
14. Sanchez DNR, Bertanha M, Fernandes TD, Resende LA de L, Deffune E, Amorim RM (2017)
Effects of canine and murine mesenchymal stromal cell transplantation on peripheral nerve
regeneration. Int J Stem Cells. https://doi.org/10.15283/ijsc16037
15. Agarwal R, Domowicz MS, Schwartz NB, Henry J, Medintz I, Delehanty JB, Stewart MH,
Susumu K, Huston AL, Deschamps JR, Dawson PE, Palomo V, Dawson G (2015) Delivery
and tracking of quantum dot peptide bioconjugates in an intact developing avian brain. ACS
Chem Neurosci. https://doi.org/10.1021/acschemneuro.5b00022
16. Singer M, Deutschman CS, Seymour C, Shankar-Hari M, Annane D, Bauer M, Bellomo R,
Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS,
Opal SM, Rubenfeld GD, Der Poll T, Vincent JL, Angus DC (2016) The third international
consensus definitions for sepsis and septic shock (sepsis-3). JAMA J Am Med, Assoc
17. Yuk SA, Sanchez-Rodriguez DA, Tsifansky MD, Yeo Y (2018) Recent advances in
nanomedicine for sepsis treatment. Ther Deliv 9(6):435–450
18. Ashton S, Song YH, Nolan J, Cadogan E, Murray J, Odedra R, Foster J, Hall PA, Low S,
Taylor P, Ellston R, Polanska UM, Wilson J, Howes C, Smith A, Goodwin RJA, Swales JG,
Strittmatter N, Takáts Z, Nilsson A, Andren P, Trueman D, Walker M, Reimer CL, Troiano G,
Parsons D, De Witt D, Ashford M, Hrkach J, Zale S, Jewsbury PJ, Barry ST (2016) Aurora
kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo. Sci Transl
Med. https://doi.org/10.1126/scitranslmed.aad2355
19. Ward NS, Levy MM (2017) Sepsis: definitions, Pathophysiology and the challenge of bedside
management. Humana Press, Cham (Switzerland)
20. Sondi I, Salopek-Sondi B (2004) Silver nanoparticles as antimicrobial agent: a case study on
E. coli as a model for Gram-negative bacteria. J Colloid Interface Sci. https://doi.org/10.1016/
j.jcis.2004.02.012
21. Le Ouay B, Stellacci F (2015) Antibacterial activity of silver nanoparticles: a surface science
insight. Nano Today
22. Pal S, Tak YK, Song JM (2007) Does the antibacterial activity of silver nanoparticles depend
on the shape of the nanoparticle? A study of the gram-negative bacterium Escherichia coli.
Appl Environ Microbiol. https://doi.org/10.1128/AEM.02218-06
23. Lansdown ABG (2006) Silver in health care: antimicrobial effects and safety in use. Curr Probl
Dermatol 33:17–34
24. Lam SJ, O’Brien-Simpson NM, Pantarat N, Sulistio A, Wong EHH, Chen YY, Lenzo JC, Holden
JA, Blencowe A, Reynolds EC, Qiao GG (2016) Combating multidrug-resistant gram-negative
bacteria with structurally nanoengineered antimicrobial peptide polymers. Nat Microbiol.
https://doi.org/10.1038/nmicrobiol.2016.162
25. Gessner I, Neundorf I (2020) Nanoparticles Modified with cell-penetrating peptides: conjugation mechanisms, physicochemical properties, and application in cancer diagnosis and therapy.
Int J Mol Sci 21:1–21. https://doi.org/10.3390/ijms21072536
26. Silva S, Almeida AJ, Vale N (2019) Combination of cell-penetrating peptides with nanoparticles
for therapeutic application: a review. Biomol