Two Dimensional Infrared Spectroscopy …
53
7 Closing Remarks
2D IR spectroscopy began its journey from applications on small molecular
complexes, dipeptides, and other model compounds. However, in the recent years,
the spectroscopic technique has been applied to larger and more complex chemical/biological systems to measure dipolar orientation, structural fluctuation, and
conformational dynamics. 2D IR is no longer limited to samples in the condensed
phase; technological advances have allowed the application of 2D IR in thin films
and gas-phase samples. Technology development continues to impact 2D IR spectroscopy. Advances in mid-IR laser source technologies, pulse shaping, and novel
combinations of 2D IR with other experimental techniques will continue to push 2D
IR to be applied on more heterogeneous systems to obtain information about structure
and ultrafast dynamics. These information, when coupled to computational results
would provide molecular insights towards structure–function relation of the system
of interest. Additionally, further advances in detection systems, novel techniques for
generating, amplifying, and compressing mid-IR pulses would likely lead to newer
innovations in the field of 2D IR spectroscopy. In a nutshell, a multi-disciplinary
approach from the fields on chemistry, physics, and biology in future will lead to
new generation technological advances and applications of 2D IR spectroscopy.
References
1. J.D. Hybl, A.W. Albrecht, S.M.G. Faeder, D.M. Jonas, Chem. Phys. Lett. 297, 307–313 (1998)
2. P. Hamm, M.H. Lim, R.M. Hochstrasser, J. Phys. Chem. B 102, 6123–6138 (1998)
3. W. Xiong, J.E. Laaser, R.D. Mehlenbacher, M.T. Zanni, Proc. Natl. Acad. Sci. U. S. A. 108,
20902–20907 (2011)
4. K. Inoue, S. Nihonyanagi, P.C. Singh, S. Yamaguchi, T. Tahara, J. Chem. Phys. 142, 212431
(2015)
5. T.L. Courtney, Z.W. Fox, L. Estergreen, M. Khalil, J. Phys. Chem. Lett. 6, 1286–1292 (2015)
6. T.A.A. Oliver, N.H.C. Lewis, G.R. Fleming, Proc. Natl. Acad. Sci. U. S. A. 111, 10061–10066
(2014)
7. B.M. Luther, K.M. Tracy, M. Gerrity, S. Brown, A.T. Krummel, Opt. Express 24, 4117–4127
(2016)
8. P.M. Donaldson, G.M. Greetham, D.J. Shaw, A.W. Parker, M. Towrie, J. Phys. Chem. A 122,
780–787 (2018)
9. R.M. Hochstrasser, Chem. Phys. 266, 273–284 (2001)
10. Y.J. Yan, R.E. Gillilan, R.M. Whitnell, K.R. Wilson, S. Mukamel, J. Phys. Chem. 97, 2320–
2333 (1993)
11. K. Lazonder, M.S. Pshenichnikov, D.A. Wiersma, Opt. Lett. 31, 3354–3356 (2006)
12. N. Demirdöven, M. Khalil, A. Tokmakoff, Phys. Rev. Lett. 89, 237401 (2002)
13. K. Kwak, D.E. Rosenfeld, M.D. Fayer, J. Chem. Phys. 128, 204505 (2008)
14. K. Kwak, S. Park, I.J. Finkelstein, M.D. Fayer, J. Chem. Phys. 127, 124503 (2007)
15. S. Bagchi, Y.S. Kim, A.K. Charnley, A.B. Smith, R.M. Hochstrasser, J. Phys. Chem. B 111,
3010–3018 (2007)
16. Y.S. Kim, J.P. Wang, R.M. Hochstrasser, J. Phys. Chem. B 109, 7511–7521 (2005)
17. P. Deb, G.Y. Jin, S.K. Singh, J. Moon, H. Kwon, A. Das, S. Bagchi, Y.S. Kim, J. Phys. Chem.
Lett. 9, 5425–5429 (2018)
53
7 Closing Remarks
2D IR spectroscopy began its journey from applications on small molecular
complexes, dipeptides, and other model compounds. However, in the recent years,
the spectroscopic technique has been applied to larger and more complex chemical/biological systems to measure dipolar orientation, structural fluctuation, and
conformational dynamics. 2D IR is no longer limited to samples in the condensed
phase; technological advances have allowed the application of 2D IR in thin films
and gas-phase samples. Technology development continues to impact 2D IR spectroscopy. Advances in mid-IR laser source technologies, pulse shaping, and novel
combinations of 2D IR with other experimental techniques will continue to push 2D
IR to be applied on more heterogeneous systems to obtain information about structure
and ultrafast dynamics. These information, when coupled to computational results
would provide molecular insights towards structure–function relation of the system
of interest. Additionally, further advances in detection systems, novel techniques for
generating, amplifying, and compressing mid-IR pulses would likely lead to newer
innovations in the field of 2D IR spectroscopy. In a nutshell, a multi-disciplinary
approach from the fields on chemistry, physics, and biology in future will lead to
new generation technological advances and applications of 2D IR spectroscopy.
References
1. J.D. Hybl, A.W. Albrecht, S.M.G. Faeder, D.M. Jonas, Chem. Phys. Lett. 297, 307–313 (1998)
2. P. Hamm, M.H. Lim, R.M. Hochstrasser, J. Phys. Chem. B 102, 6123–6138 (1998)
3. W. Xiong, J.E. Laaser, R.D. Mehlenbacher, M.T. Zanni, Proc. Natl. Acad. Sci. U. S. A. 108,
20902–20907 (2011)
4. K. Inoue, S. Nihonyanagi, P.C. Singh, S. Yamaguchi, T. Tahara, J. Chem. Phys. 142, 212431
(2015)
5. T.L. Courtney, Z.W. Fox, L. Estergreen, M. Khalil, J. Phys. Chem. Lett. 6, 1286–1292 (2015)
6. T.A.A. Oliver, N.H.C. Lewis, G.R. Fleming, Proc. Natl. Acad. Sci. U. S. A. 111, 10061–10066
(2014)
7. B.M. Luther, K.M. Tracy, M. Gerrity, S. Brown, A.T. Krummel, Opt. Express 24, 4117–4127
(2016)
8. P.M. Donaldson, G.M. Greetham, D.J. Shaw, A.W. Parker, M. Towrie, J. Phys. Chem. A 122,
780–787 (2018)
9. R.M. Hochstrasser, Chem. Phys. 266, 273–284 (2001)
10. Y.J. Yan, R.E. Gillilan, R.M. Whitnell, K.R. Wilson, S. Mukamel, J. Phys. Chem. 97, 2320–
2333 (1993)
11. K. Lazonder, M.S. Pshenichnikov, D.A. Wiersma, Opt. Lett. 31, 3354–3356 (2006)
12. N. Demirdöven, M. Khalil, A. Tokmakoff, Phys. Rev. Lett. 89, 237401 (2002)
13. K. Kwak, D.E. Rosenfeld, M.D. Fayer, J. Chem. Phys. 128, 204505 (2008)
14. K. Kwak, S. Park, I.J. Finkelstein, M.D. Fayer, J. Chem. Phys. 127, 124503 (2007)
15. S. Bagchi, Y.S. Kim, A.K. Charnley, A.B. Smith, R.M. Hochstrasser, J. Phys. Chem. B 111,
3010–3018 (2007)
16. Y.S. Kim, J.P. Wang, R.M. Hochstrasser, J. Phys. Chem. B 109, 7511–7521 (2005)
17. P. Deb, G.Y. Jin, S.K. Singh, J. Moon, H. Kwon, A. Das, S. Bagchi, Y.S. Kim, J. Phys. Chem.
Lett. 9, 5425–5429 (2018)