658
S. P. Singh and S. Siddhanta
power, and at the right wavelength, the correct optics to deliver the light (e.g. fibers or
diffusers), and subsequently collect the light (e.g. lenses and filters) onto a detector
or camera. It is also very much desired to develop brighter and more photostable
chromophores which can help in fully exploiting the potential of these methods.
Another key challenge that requires significant attention of the scientific community is minimizing the attenuation and scattering losses in biological tissues. Wide
utilization of light sources and detectors in the infrared region could be an option to
tackle this aspect. Despite these challenges, optical techniques have growing roles
in molecular imaging research and clinical translation. Still, a lot of work needs to
be done to fully appreciate the potential of these methods to unravel some of the
lingering biological mysteries.
References
1. C.R. Keeler, Arch. Ophthalmol. 120, 194 (2002)
2. S. Wang, I.V. Larina, K.V. Larin, Biomed Opt Express 11, 2017 (2020)
3. B.P. Joshi, T.D. Wang, Cancers 2, 1251 (2010)
4. K. Licha, Contrast Agents II (Springer, 2002), pp. 1
5. R.S. DaCosta, B.C. Wilson, N.E. Marcon, Best Pract. Res. Clin. Gastroenterol. 20, 41 (2006)
6. D.A. Long, New York, 1 (1977)
7. A. Downes, R. Mouras, A. Elfick, J. Raman Spectrosc: An International Journal for Original
Work in all Aspects of Raman Spectroscopy, Including Higher Order Processes, and also
Brillouin and Rayleigh Scattering 40, 757 (2009)
8. F. Hu, L. Shi, W. Min, Nat. Methods 16, 830 (2019)
9. Z. Zhao, Y. Shen, F. Hu, W. Min, Analyst 142, 4018 (2017)
10. J. Ju, S. Kumar, M. Palla, J (J. Russo, Google Patents, 2020)
11. N.A. Hagen, M.W. Kudenov, Opt. Eng. 52, 090901 (2013)
12. A. Blat et al., Sci. Rep. 9, 15475 (2019)
13. S.J. Remington, Protein science: a publication of the Protein Society 20, 1509 (2011)
14. O. Shimomura, Angew. Chem. 48, 5590 (2009)
15. M.F. Abad, G. Di Benedetto, P.J. Magalhães, L. Filippin, T. Pozzan, J. Biol. Chem. 279, 11521
(2004)
16. A. Miyawaki, J. Llopis, R. Heim, J.M. McCaffery, J.A. Adams, M. Ikura, R.Y. Tsien, Nature
388, 882 (1997)
17. J.D. Morris, C.K. Payne, Annu. Rev. Phys. Chem. 70, 199 (2019)
18. P.P. Mondal, Frontiers Mol Biosci 1, 11 (2014)
19. R. Datta, T.M. Heaster, J.T. Sharick, A.A. Gillette, M.C. Skala, J Biomed Opt 25, 1 (2020)
20. R. Ebrecht, C. Don Paul, F.S. Wouters, Protoplasma 251, 293 (2014)
21. K. Suhling et al., Med Photonics 27, 3 (2015)
22. R. Datta, T. Heaster, J. Sharick, A. Gillette, M. Skala, J. Biomed. Opt. 25, 071203 (2020)
23. X. Liu, D. Lin, W. Becker, J. Niu, B. Yu, L. Liu, J. Qu, J. Innovative Opt. Health Sci. 12,
1930003 (2019)
24. Y. Ardeshirpour et al., PLoS ONE 7, e31881 (2012)
25. S. Bloch, F. Lesage, L. McIntosh, A. Gandjbakhche, K. Liang, S. Achilefu, J. Biomed. Opt.
10, 054003 (2005)
26. M.A. Yaseen, J. Sutin, W. Wu, B. Fu, H. Uhlirova, A. Devor, D.A. Boas, S. Sakadži´ c, Biomed.
Opt. Express 8, 2368 (2017)
27. S. Chakraborty, F.-S. Nian, J.-W. Tsai, A. Karmenyan, A. Chiou, Scientific Reports 6, 19145
(2016)
S. P. Singh and S. Siddhanta
power, and at the right wavelength, the correct optics to deliver the light (e.g. fibers or
diffusers), and subsequently collect the light (e.g. lenses and filters) onto a detector
or camera. It is also very much desired to develop brighter and more photostable
chromophores which can help in fully exploiting the potential of these methods.
Another key challenge that requires significant attention of the scientific community is minimizing the attenuation and scattering losses in biological tissues. Wide
utilization of light sources and detectors in the infrared region could be an option to
tackle this aspect. Despite these challenges, optical techniques have growing roles
in molecular imaging research and clinical translation. Still, a lot of work needs to
be done to fully appreciate the potential of these methods to unravel some of the
lingering biological mysteries.
References
1. C.R. Keeler, Arch. Ophthalmol. 120, 194 (2002)
2. S. Wang, I.V. Larina, K.V. Larin, Biomed Opt Express 11, 2017 (2020)
3. B.P. Joshi, T.D. Wang, Cancers 2, 1251 (2010)
4. K. Licha, Contrast Agents II (Springer, 2002), pp. 1
5. R.S. DaCosta, B.C. Wilson, N.E. Marcon, Best Pract. Res. Clin. Gastroenterol. 20, 41 (2006)
6. D.A. Long, New York, 1 (1977)
7. A. Downes, R. Mouras, A. Elfick, J. Raman Spectrosc: An International Journal for Original
Work in all Aspects of Raman Spectroscopy, Including Higher Order Processes, and also
Brillouin and Rayleigh Scattering 40, 757 (2009)
8. F. Hu, L. Shi, W. Min, Nat. Methods 16, 830 (2019)
9. Z. Zhao, Y. Shen, F. Hu, W. Min, Analyst 142, 4018 (2017)
10. J. Ju, S. Kumar, M. Palla, J (J. Russo, Google Patents, 2020)
11. N.A. Hagen, M.W. Kudenov, Opt. Eng. 52, 090901 (2013)
12. A. Blat et al., Sci. Rep. 9, 15475 (2019)
13. S.J. Remington, Protein science: a publication of the Protein Society 20, 1509 (2011)
14. O. Shimomura, Angew. Chem. 48, 5590 (2009)
15. M.F. Abad, G. Di Benedetto, P.J. Magalhães, L. Filippin, T. Pozzan, J. Biol. Chem. 279, 11521
(2004)
16. A. Miyawaki, J. Llopis, R. Heim, J.M. McCaffery, J.A. Adams, M. Ikura, R.Y. Tsien, Nature
388, 882 (1997)
17. J.D. Morris, C.K. Payne, Annu. Rev. Phys. Chem. 70, 199 (2019)
18. P.P. Mondal, Frontiers Mol Biosci 1, 11 (2014)
19. R. Datta, T.M. Heaster, J.T. Sharick, A.A. Gillette, M.C. Skala, J Biomed Opt 25, 1 (2020)
20. R. Ebrecht, C. Don Paul, F.S. Wouters, Protoplasma 251, 293 (2014)
21. K. Suhling et al., Med Photonics 27, 3 (2015)
22. R. Datta, T. Heaster, J. Sharick, A. Gillette, M. Skala, J. Biomed. Opt. 25, 071203 (2020)
23. X. Liu, D. Lin, W. Becker, J. Niu, B. Yu, L. Liu, J. Qu, J. Innovative Opt. Health Sci. 12,
1930003 (2019)
24. Y. Ardeshirpour et al., PLoS ONE 7, e31881 (2012)
25. S. Bloch, F. Lesage, L. McIntosh, A. Gandjbakhche, K. Liang, S. Achilefu, J. Biomed. Opt.
10, 054003 (2005)
26. M.A. Yaseen, J. Sutin, W. Wu, B. Fu, H. Uhlirova, A. Devor, D.A. Boas, S. Sakadži´ c, Biomed.
Opt. Express 8, 2368 (2017)
27. S. Chakraborty, F.-S. Nian, J.-W. Tsai, A. Karmenyan, A. Chiou, Scientific Reports 6, 19145
(2016)