502
Table 8.2 Caspases Relevant to Drug Design
Caspace
Alternate nonmenclature
Function
Substrates
Caspase-1
ICE
Processing of interleukins
Interleukin-18
(inflammation)
Lamins
pre-Interleukin-1β
Caspase-2
Ich-1
Apoptosis
Golgin-160
Caspase-3
CPP32
Apoptosis
β-Catenin
Calpastatin
Caspase-6
Caspase-7
Caspase-9
DNA–PK
FAK
Fodrin
Gas2
Gelsolin
HnRNP proteins
ICAD
Lamins
MDM2
PARP
Presenilin2
Topoisomerase I
Caspase-4
Ich-2, ICE II
Caspase-1
Caspase-5
ICE III, TY
Inflammation/Apoptosis
Caspase-6
Mch2
Apoptosis
Caspase-3
FAK
Keratin-18
NuMA
PARP
Caspase-7
Mch3, ICE-LAP3, CMH-1
Apoptosis
Calpastatin
EMAP II
FAK
PARP
SREB1
Caspase-8
FLICE, MACH, Mch5
Apoptosis
Caspase-3
Caspase-4
Caspase-6
Caspase-7
Caspase-9
Caspase-10
Caspase-13
PARP
(Continued)