also remember that drugs designed to target CNS receptors can have systemic side
effects and that drugs targeting systemic problems can have CNS side effects.
4.6.4.3 H 3 Antagonists
Several lines of evidence suggest a role for H 3 receptors in cognitive processes. The use
of H 3 antagonists in learning and memory disorders has been suggested. Thioperamide,
a prototypic H 3 antagonist, enhances arousal patterns in cats, an observation which has
been confirmed using other nonthiourea H 3 blockers.
4.6.5 The Clinical–Molecular Interface: The Many Uses and
Abuses of H 1 Receptor Antagonists
H 1 receptor antagonists (antihistamines) are among the most widely used therapeutic
agents. Indeed, sometimes the exact same molecule (e.g., diphenhydramine) is marketed in different aisles in the same pharmacy under many brand names for different
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effects and that drugs targeting systemic problems can have CNS side effects.
4.6.4.3 H 3 Antagonists
Several lines of evidence suggest a role for H 3 receptors in cognitive processes. The use
of H 3 antagonists in learning and memory disorders has been suggested. Thioperamide,
a prototypic H 3 antagonist, enhances arousal patterns in cats, an observation which has
been confirmed using other nonthiourea H 3 blockers.
4.6.5 The Clinical–Molecular Interface: The Many Uses and
Abuses of H 1 Receptor Antagonists
H 1 receptor antagonists (antihistamines) are among the most widely used therapeutic
agents. Indeed, sometimes the exact same molecule (e.g., diphenhydramine) is marketed in different aisles in the same pharmacy under many brand names for different
NEUROTRANSMITTERS AND THEIR RECEPTORS
269