APPENDIX 3.1: BASIC REACTIONS FOR DRUG
MOLECULE SYNTHESIS
A. Building Blocks for the Framework Structure:
C-C, C=C, C≡C, and C-H Bond Formation
C-C Bond Formation
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MEDICINAL CHEMISTRY
1. Acetoacetic ester synthesis
2. Aldol reaction
3. Alkylation of ketone enolate anion
4. Claisen condensation
5. Claisen rearrangement