3
Stereochemistry
Learning objectives
After completing this chapter the student should be able to
define stereochemistry;
outline different types of isomerism;
distinguish between conformational isomers and configurational isomers;
discuss conformational isomerism in alkanes;
explain the terms torsional energy, torsional strain, angle strain, enantiomers, chirality, specific rotation, optical activity, diastereomers, meso
compounds and racemic mixture;
designate the configuration of enantiomers using the D and L system and
the (R) and (S) system;
explain geometrical isomerism in alkenes and cyclic compounds;
outline the synthesis of chiral molecules;
explain resolution of racemic mixtures;
discuss the significance of stereoisomerism in determining drug action and
toxicity.
Chemistry for Pharmacy Students Satyajit D Sarker and Lutfun Nahar
# 2007 John Wiley & Sons, Ltd.