126 Les biomarqueurs moléculaires en oncologie
20. Barnett GC, Coles CE, Elliott RM, et al. (2012) Independent validation of genes and
l l
polymorphisms reported to be associated with radiation toxicity: a prospective analysis
study. Lancet Oncol 13(1): 65-77
21. Barnett GC, Elliott RM, Alsner J, et al. (2012) Individual patient data meta-analysis
shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity.
Radiother Oncol 105(3): 289-95
22. Voets AM, Oberije C, Struijk RB, et al. (2012) No association between TGF-beta1
l l
polymorphisms and radiation-induced lung toxicity in a European cohort of lung cancer
patients. Radiother Oncol 105(3): 296-8
23. Frayling TM, Timpson NJ, Weedon MN, et al. (2007) A common variant in the FTO
l l
gene is associated with body mass index and predisposes to childhood and adult obesity.
Science 316(5826): 889-94
24. Liu YJ, Liu XG, Wang L, et al. (2008) Genome-wide association scans identified CTNNBL1
as a novel gene for obesity. Hum Mol Genet 17(12): 1803-13
25. Saxena R, Voight BF, Lyssenko V, et al. (2007) Genome-wide association analysis identifies
loci for type 2 diabetes and triglyceride levels. Science 316(5829): 1331-6
26. Newton-Cheh C, Guo CY, Wang TJ, et al. (2007) Genome-wide association study of
electrocardiographic and heart rate variability traits: the Framingham Heart Study. BMC
Med Genet 8 Suppl 1: S7
27. Kerns SL, Ostrer H, Stock R, et al. (2010) Genome-wide association study to identify
single nucleotide polymorphisms (SNPs) associated with the development of erectile
dysfunction in African-American men after radiotherapy for prostate cancer. Int J Radiat
Oncol Biol Phys 78(5): 1292-300
28. Best T, Li D, Skol AD, et al. (2011) Variants at 6q21 implicate PRDM1 in the etiology of
therapy-induced second malignancies after Hodgkin’s lymphoma. Nat Med 17(8): 941-3
29. West C, Rosenstein BS, Alsner J, et al. (2010) Establishment of a Radiogenomics
l l
Consortium. Int J Radiat Oncol Biol Phys 76(5): 1295-6
30. Hummerich J, Werle-Schneider G, Popanda O, et al. (2006) Constitutive mRNA
l l
expression of DNA repair-related genes as a biomarker for clinical radio-resistance: A pilot
study in prostate cancer patients receiving radiotherapy. Int J Radiat Biol 82(8): 593-604
31. Wiebalk K, Schmezer P, Kropp S, et al. (2007) In vitro radiation-induced expression of
l l
XPC mRNA as a possible biomarker for developing adverse reactions during radiotherapy.
Int J Cancer 121(10): 2340-5
32. Mayer C, Popanda O, Greve B, et al. (2011) A radiation-induced gene expression signature
as a tool to predict acute radiotherapy-induced adverse side effects. Cancer Lett 302(1):
20-8
33. Wagner-Ecker M, Schwager C, Wirkner U, et al. (2010) MicroRNA expression after
ionizing radiation in human endothelial cells. Radiat Oncol 5: 25
34. Chaudhry MA, Kreger B, Omaruddin RA (2010) Transcriptional modulation of
micro-RNA in human cells differing in radiation sensitivity. Int J Radiat Biol 86(7): 569-83
35. Kato M, Paranjape T, Muller RU, et al. (2009) The mir-34 microRNA is required for the
DNA damage response in vivo in C. elegans and in vitro in human breast cancer cells.
Oncogene 28(25): 2419-24
36. Lu X, de la Pena L, Barker C, et al. (2006) Radiation-induced changes in gene expression
l l
involve recruitment of existing messenger RNAs to and away from polysomes. Cancer Res
66(2): 1052-61
37. Zhao L, Sheldon K, Chen M, et al. (2008) The predictive role of plasma TGF-beta1 during
radiation therapy for radiation-induced lung toxicity deserves further study in patients with
non-small cell lung cancer. Lung Cancer 59(2): 232-9
38. Zhao L, Wang L, Ji W, et al. (2009) Elevation of plasma TGF-beta1 during radiation
therapy predicts radiation-induced lung toxicity in patients with non-small-cell lung
cancer: a combined analysis from Beijing and Michigan. Int J Radiat Oncol Biol Phys
74(5): 1385-90
20. Barnett GC, Coles CE, Elliott RM, et al. (2012) Independent validation of genes and
l l
polymorphisms reported to be associated with radiation toxicity: a prospective analysis
study. Lancet Oncol 13(1): 65-77
21. Barnett GC, Elliott RM, Alsner J, et al. (2012) Individual patient data meta-analysis
shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity.
Radiother Oncol 105(3): 289-95
22. Voets AM, Oberije C, Struijk RB, et al. (2012) No association between TGF-beta1
l l
polymorphisms and radiation-induced lung toxicity in a European cohort of lung cancer
patients. Radiother Oncol 105(3): 296-8
23. Frayling TM, Timpson NJ, Weedon MN, et al. (2007) A common variant in the FTO
l l
gene is associated with body mass index and predisposes to childhood and adult obesity.
Science 316(5826): 889-94
24. Liu YJ, Liu XG, Wang L, et al. (2008) Genome-wide association scans identified CTNNBL1
as a novel gene for obesity. Hum Mol Genet 17(12): 1803-13
25. Saxena R, Voight BF, Lyssenko V, et al. (2007) Genome-wide association analysis identifies
loci for type 2 diabetes and triglyceride levels. Science 316(5829): 1331-6
26. Newton-Cheh C, Guo CY, Wang TJ, et al. (2007) Genome-wide association study of
electrocardiographic and heart rate variability traits: the Framingham Heart Study. BMC
Med Genet 8 Suppl 1: S7
27. Kerns SL, Ostrer H, Stock R, et al. (2010) Genome-wide association study to identify
single nucleotide polymorphisms (SNPs) associated with the development of erectile
dysfunction in African-American men after radiotherapy for prostate cancer. Int J Radiat
Oncol Biol Phys 78(5): 1292-300
28. Best T, Li D, Skol AD, et al. (2011) Variants at 6q21 implicate PRDM1 in the etiology of
therapy-induced second malignancies after Hodgkin’s lymphoma. Nat Med 17(8): 941-3
29. West C, Rosenstein BS, Alsner J, et al. (2010) Establishment of a Radiogenomics
l l
Consortium. Int J Radiat Oncol Biol Phys 76(5): 1295-6
30. Hummerich J, Werle-Schneider G, Popanda O, et al. (2006) Constitutive mRNA
l l
expression of DNA repair-related genes as a biomarker for clinical radio-resistance: A pilot
study in prostate cancer patients receiving radiotherapy. Int J Radiat Biol 82(8): 593-604
31. Wiebalk K, Schmezer P, Kropp S, et al. (2007) In vitro radiation-induced expression of
l l
XPC mRNA as a possible biomarker for developing adverse reactions during radiotherapy.
Int J Cancer 121(10): 2340-5
32. Mayer C, Popanda O, Greve B, et al. (2011) A radiation-induced gene expression signature
as a tool to predict acute radiotherapy-induced adverse side effects. Cancer Lett 302(1):
20-8
33. Wagner-Ecker M, Schwager C, Wirkner U, et al. (2010) MicroRNA expression after
ionizing radiation in human endothelial cells. Radiat Oncol 5: 25
34. Chaudhry MA, Kreger B, Omaruddin RA (2010) Transcriptional modulation of
micro-RNA in human cells differing in radiation sensitivity. Int J Radiat Biol 86(7): 569-83
35. Kato M, Paranjape T, Muller RU, et al. (2009) The mir-34 microRNA is required for the
DNA damage response in vivo in C. elegans and in vitro in human breast cancer cells.
Oncogene 28(25): 2419-24
36. Lu X, de la Pena L, Barker C, et al. (2006) Radiation-induced changes in gene expression
l l
involve recruitment of existing messenger RNAs to and away from polysomes. Cancer Res
66(2): 1052-61
37. Zhao L, Sheldon K, Chen M, et al. (2008) The predictive role of plasma TGF-beta1 during
radiation therapy for radiation-induced lung toxicity deserves further study in patients with
non-small cell lung cancer. Lung Cancer 59(2): 232-9
38. Zhao L, Wang L, Ji W, et al. (2009) Elevation of plasma TGF-beta1 during radiation
therapy predicts radiation-induced lung toxicity in patients with non-small-cell lung
cancer: a combined analysis from Beijing and Michigan. Int J Radiat Oncol Biol Phys
74(5): 1385-90