stream effector of the calcineurin pathway, is
required during tunicamycin-induced ER stress
response in Candida albicans. FEMS Yeast Res 15
(8):fov095
Timpel C, Strahl-Bolsinger S, Ziegelbauer K, Ernst JF
(1998) Multiple functions of Pmt1p-mediated protein O-mannosylation in the fungal pathogen Candida albicans. J Biol Chem 273:20837–20846
Timpel C, Zink S, Strahl-Bolsinger S, Schroppel K,
Ernst J (2000) Morphogenesis, adhesive properties, and antifungal resistance depend on the
Pmt6 protein mannosyltransferase in the
fungal pathogen Candida albicans. J Bacteriol
182:3063–3071
Travers KJ, Patil CK, Wodicka L, Lockhart DJ, Weissman JS, Walter P (2000) Functional and genomic
analyses reveal an essential coordination between
the unfolded protein response and ER-associated
degradation. Cell 101:249–258
Valkonen M, Penttila M, Saloheimo M (2004) The ire1
and ptc2 genes involved in the unfolded protein
response pathway in the filamentous fungus Trichoderma reesei. Mol Genet Genomics MGG
272:443–451
van Gemeren IA, Punt PJ, Drint-Kuyvenhoven A, Broekhuijsen MP, van’t Hoog A, Beijersbergen A, Verrips CT, van den Hondel CA (1997) The ER
chaperone encoding bipA gene of black Aspergilli
is induced by heat shock and unfolded proteins.
Gene 198:43–52
Vembar SS, Jin Y, Brodsky JL, Hendershot LM (2009)
The mammalian Hsp40 ERdj3 requires its Hsp70
interaction and substrate-binding properties to
complement various yeast Hsp40-dependent functions. J Biol Chem 284:32462–32471
Voigt O, Po ¨ggeler S (2013) Self-eating to grow and kill:
autophagy in filamentous ascomycetes. Appl
Microbiol Biotechnol 97:9277–9290
Weihofen A, Binns K, Lemberg MK, Ashman K, Martoglio B (2002) Identification of signal peptide
peptidase, a presenilin-type aspartic protease. Science 296:2215–2218
Welihinda AA, Tirasophon W, Green SR, Kaufman RJ
(1998) Protein serine/threonine phosphatase
Ptc2p negatively regulates the unfolded-protein
response by dephosphorylating Ire1p kinase. Mol
Cell Biol 18:1967–1977
Wimalasena TT, Enjalbert B, Guillemette T, Plumridge
A, Budge S, Yin Z, Brown AJ, Archer DB (2008)
Impact of the unfolded protein response upon
genome-wide expression patterns, and the role of
Hac1 in the polarized growth, of Candida albicans.
Fungal Genet Biol 45:1235–1247
Wiseman RL, Zhang Y, Lee KP, Harding HP, Haynes
CM, Price J, Sicheri F, Ron D (2010) Flavonol
activation defines an unanticipated ligand-binding
site in the kinase-RNase domain of IRE1. Mol Cell
38:291–304
Yamamoto K, Yoshida H, Kokame K, Kaufman RJ,
Mori K (2004) Differential contributions of
ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II. J Biochem
136:343–350
Yan X, Talbot NJ (2016) Investigating the cell biology of
plant infection by the rice blast fungus Magnaporthe oryzae. Curr Opin Microbiol 34:147–153
Yin Z, Feng W, Chen C, Xu J, Li Y, Yang L, Wang J, Liu
X, Wang W, Gao C, Zhang H, Zheng X, Wang P,
Zhang Z (2019) Shedding light on autophagy coordinating with cell wall integrity signaling to govern
pathogenicity of Magnaporthe oryzae. Autophagy:1–17
Yin Z, Tang W, Wang J, Liu X, Yang L, Gao C, Zhang J,
Zhang H, Zheng X, Wang P, Zhang Z (2016) Phosphodiesterase MoPdeH targets MoMck1 of the
conserved mitogen-activated protein (MAP)
kinase signalling pathway to regulate cell wall
integrity in rice blast fungus Magnaporthe oryzae.
Mol Plant Pathol 17:654–668
Yu Z, Armant O, Fischer R (2016) Fungi use the SakA
(HogA) pathway for phytochrome-dependent light
signalling. Nat Microbiol 1:16019
Zhai P, Song J, Gao L, Lu L (2019) A sphingolipid
synthesis-related protein OrmA in Aspergillus
fumigatus is responsible for azole susceptibility
and virulence. Cell Microbiol 21:e13092
Zhang H, Li Y, Dickman MB, Wang Z (2019) Cytoprotective co-chaperone BcBAG1 is a component for
fungal development, virulence, and unfolded protein response (UPR) of Botrytis cinerea. Front
Microbiol 10:685
Zhang L, Zhang C, Wang A (2016b) Divergence and
conservation of the major UPR branch IRE1-bZIP
signaling pathway across eukaryotes. Sci Rep
6:27362
Zhang H, Zheng X, Zhang Z (2016a) The Magnaporthe
grisea species complex and plant pathogenesis.
Mol Plant Pathol 17:796–804
Zhou J, Liu CY, Back SH, Clark RL, Peisach D, Xu Z,
Kaufman RJ (2006) The crystal structure of human
IRE1 luminal domain reveals a conserved dimerization interface required for activation of the
unfolded protein response. Proc Natl Acad Sci
U S A 103:14343–14348
76
R. Harting and K. Heimel
required during tunicamycin-induced ER stress
response in Candida albicans. FEMS Yeast Res 15
(8):fov095
Timpel C, Strahl-Bolsinger S, Ziegelbauer K, Ernst JF
(1998) Multiple functions of Pmt1p-mediated protein O-mannosylation in the fungal pathogen Candida albicans. J Biol Chem 273:20837–20846
Timpel C, Zink S, Strahl-Bolsinger S, Schroppel K,
Ernst J (2000) Morphogenesis, adhesive properties, and antifungal resistance depend on the
Pmt6 protein mannosyltransferase in the
fungal pathogen Candida albicans. J Bacteriol
182:3063–3071
Travers KJ, Patil CK, Wodicka L, Lockhart DJ, Weissman JS, Walter P (2000) Functional and genomic
analyses reveal an essential coordination between
the unfolded protein response and ER-associated
degradation. Cell 101:249–258
Valkonen M, Penttila M, Saloheimo M (2004) The ire1
and ptc2 genes involved in the unfolded protein
response pathway in the filamentous fungus Trichoderma reesei. Mol Genet Genomics MGG
272:443–451
van Gemeren IA, Punt PJ, Drint-Kuyvenhoven A, Broekhuijsen MP, van’t Hoog A, Beijersbergen A, Verrips CT, van den Hondel CA (1997) The ER
chaperone encoding bipA gene of black Aspergilli
is induced by heat shock and unfolded proteins.
Gene 198:43–52
Vembar SS, Jin Y, Brodsky JL, Hendershot LM (2009)
The mammalian Hsp40 ERdj3 requires its Hsp70
interaction and substrate-binding properties to
complement various yeast Hsp40-dependent functions. J Biol Chem 284:32462–32471
Voigt O, Po ¨ggeler S (2013) Self-eating to grow and kill:
autophagy in filamentous ascomycetes. Appl
Microbiol Biotechnol 97:9277–9290
Weihofen A, Binns K, Lemberg MK, Ashman K, Martoglio B (2002) Identification of signal peptide
peptidase, a presenilin-type aspartic protease. Science 296:2215–2218
Welihinda AA, Tirasophon W, Green SR, Kaufman RJ
(1998) Protein serine/threonine phosphatase
Ptc2p negatively regulates the unfolded-protein
response by dephosphorylating Ire1p kinase. Mol
Cell Biol 18:1967–1977
Wimalasena TT, Enjalbert B, Guillemette T, Plumridge
A, Budge S, Yin Z, Brown AJ, Archer DB (2008)
Impact of the unfolded protein response upon
genome-wide expression patterns, and the role of
Hac1 in the polarized growth, of Candida albicans.
Fungal Genet Biol 45:1235–1247
Wiseman RL, Zhang Y, Lee KP, Harding HP, Haynes
CM, Price J, Sicheri F, Ron D (2010) Flavonol
activation defines an unanticipated ligand-binding
site in the kinase-RNase domain of IRE1. Mol Cell
38:291–304
Yamamoto K, Yoshida H, Kokame K, Kaufman RJ,
Mori K (2004) Differential contributions of
ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II. J Biochem
136:343–350
Yan X, Talbot NJ (2016) Investigating the cell biology of
plant infection by the rice blast fungus Magnaporthe oryzae. Curr Opin Microbiol 34:147–153
Yin Z, Feng W, Chen C, Xu J, Li Y, Yang L, Wang J, Liu
X, Wang W, Gao C, Zhang H, Zheng X, Wang P,
Zhang Z (2019) Shedding light on autophagy coordinating with cell wall integrity signaling to govern
pathogenicity of Magnaporthe oryzae. Autophagy:1–17
Yin Z, Tang W, Wang J, Liu X, Yang L, Gao C, Zhang J,
Zhang H, Zheng X, Wang P, Zhang Z (2016) Phosphodiesterase MoPdeH targets MoMck1 of the
conserved mitogen-activated protein (MAP)
kinase signalling pathway to regulate cell wall
integrity in rice blast fungus Magnaporthe oryzae.
Mol Plant Pathol 17:654–668
Yu Z, Armant O, Fischer R (2016) Fungi use the SakA
(HogA) pathway for phytochrome-dependent light
signalling. Nat Microbiol 1:16019
Zhai P, Song J, Gao L, Lu L (2019) A sphingolipid
synthesis-related protein OrmA in Aspergillus
fumigatus is responsible for azole susceptibility
and virulence. Cell Microbiol 21:e13092
Zhang H, Li Y, Dickman MB, Wang Z (2019) Cytoprotective co-chaperone BcBAG1 is a component for
fungal development, virulence, and unfolded protein response (UPR) of Botrytis cinerea. Front
Microbiol 10:685
Zhang L, Zhang C, Wang A (2016b) Divergence and
conservation of the major UPR branch IRE1-bZIP
signaling pathway across eukaryotes. Sci Rep
6:27362
Zhang H, Zheng X, Zhang Z (2016a) The Magnaporthe
grisea species complex and plant pathogenesis.
Mol Plant Pathol 17:796–804
Zhou J, Liu CY, Back SH, Clark RL, Peisach D, Xu Z,
Kaufman RJ (2006) The crystal structure of human
IRE1 luminal domain reveals a conserved dimerization interface required for activation of the
unfolded protein response. Proc Natl Acad Sci
U S A 103:14343–14348
76
R. Harting and K. Heimel