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acetyltransferase EsaA increases activation of secondary metabolite production. Mol Microbiol
86:314–330
Soyer JL, El Ghalid M, Glaser N et al (2014) Epigenetic
control of effector gene expression in the plant
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Genet 10:e1004227
Stern M, Jensen R, Herskowitz I (1984) Five SWI genes
are required for expression of the HO gene in
yeast. J Mol Biol 178:853–868
Studt L, Ro ¨sler SM, Burkhardt I et al (2016) Knockdown of the methyltransferase Kmt6 relieves
H3K27me3 and results in induction of cryptic
and otherwise silent secondary metabolite gene
clusters in Fusarium fujikuroi. Environ Microbiol
18:4037–4054
Sun G, Zhou Z, Liu X et al (2016) Suppression of
WHITE COLLAR-independent frequency transcription by histone H3 lysine 36 methyltransferase SET-2 is necessary for clock function in
Neurospora. J Biol Chem 291:11055–11063
Talbert PB, Henikoff S (2010) Histone variants—
ancient wrap artists of the epigenome. Nat Rev
Mol Cell Biol 11:264–275
Tamaru H, Selker EU (2001) A histone H3 methyltransferase controls DNA methylation in Neurospora
crassa. Nature 414:277–283
Tamaru H, Selker EU (2003) Synthesis of signals for de
novo DNA methylation in Neurospora crassa. Mol
Cell Biol 23:2379–2394
Tamaru H, Zhang X, McMillen D et al (2003) Trimethylated lysine 9 of histone H3 is a mark for DNA
methylation in Neurospora crassa. Nat Genet
34:75–79
Trojer P, Reinberg D (2007) Facultative heterochromatin: is there a distinctive molecular signature? Mol
Cell 28:1–13
Verdone L, Caserta M, Di Mauro E (2005) Role of
histone acetylation in the control of gene expression. Biochem Cell Biol 83:344–353
Wang Y, Dong Q, Ding Z et al (2016) Regulation of
Neurospora catalase-3 by global heterochromatin
formation and its proximal heterochromatin
region. Free Radic Biol Med 99:139–152
Wang B, Kettenbach AN, Gerber SA et al (2014) Neurospora WC-1 recruits SWI/SNF to remodel frequency and initiate a circadian cycle. PLoS Genet
10:e1004599
Wang Y, Smith KM, Taylor JW, et al (2015) Endogenous small RNA mediates meiotic silencing of a
novel DNA transposon. G3 5:1949–1960
Wendte JM, Pikaard CS (2017) The RNAs of RNAdirected DNA methylation. Biochim Biophys Acta
Gene Regul Mech 1860:140–148
Xiong L, Adhvaryu KK, Selker EU, Wang Y (2010)
Mapping of lysine methylation and acetylation in
core histones of Neurospora crassa. Biochemistry
49:5236–5243
Xu H, Wang J, Hu Q et al (2010) DCAF26, an adaptor
protein of Cul4-based E3, is essential for DNA
methylation in Neurospora crassa. PLoS Genet 6:
e1001132
Xue Z, Ye Q, Anson SR et al (2014) Transcriptional
interference by antisense RNA is required for circadian clock function. Nature 514:650–653
Yang Z, Qian S, Scheid RN et al (2018) EBS is a bivalent
histone reader that regulates floral phase transition in Arabidopsis. Nat Genet 50:1247–1253
Zacharias H (1995) Emil Heitz (1892-1965): chloroplasts, heterochromatin, and polytene chromosomes. Genetics 141:7–14
Zhang X, Tamaru H, Khan SI et al (2002) Structure of
the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase. Cell 111:117–127
Zhang X, Yang Z, Khan SI et al (2003) Structural basis
for the product specificity of histone lysine
methyltransferases. Mol Cell 12:177–185
Zhao Y, Shen Y, Yang S et al (2010) Ubiquitin ligase
components Cullin4 and DDB1 are essential for
DNA methylation in Neurospora crassa. J Biol
Chem 285:4355–4365
Zhou Y, Cambareri EB, Kinsey JA (2001) DNA methylation inhibits expression and transposition of the
Neurospora tad retrotransposon. Mol Gen Genomics 265:748–754
Zhou Z, Liu X, Hu Q et al (2013) Suppression of WCindependent frequency transcription by RCO-1 is
essential for Neurospora circadian clock. Proc Natl
Acad Sci U S A 110:E4867–E4874
Zhu Q, Ramakrishnan M, Park J, Belden WJ (2019)
Histone H3 lysine 4 methyltransferase is required
for facultative heterochromatin at specific loci.
BMC Genomics 20:350
Zou JX, Revenko AS, Li LB et al (2007) ANCCA, an
estrogen-regulated AAA+ ATPase coactivator for
ERalpha, is required for coregulator occupancy
and chromatin modification. Proc Natl Acad Sci
U S A 104:18067–18072
24
A. J. Courtney et al.
acetyltransferase EsaA increases activation of secondary metabolite production. Mol Microbiol
86:314–330
Soyer JL, El Ghalid M, Glaser N et al (2014) Epigenetic
control of effector gene expression in the plant
pathogenic fungus Leptosphaeria maculans. PLoS
Genet 10:e1004227
Stern M, Jensen R, Herskowitz I (1984) Five SWI genes
are required for expression of the HO gene in
yeast. J Mol Biol 178:853–868
Studt L, Ro ¨sler SM, Burkhardt I et al (2016) Knockdown of the methyltransferase Kmt6 relieves
H3K27me3 and results in induction of cryptic
and otherwise silent secondary metabolite gene
clusters in Fusarium fujikuroi. Environ Microbiol
18:4037–4054
Sun G, Zhou Z, Liu X et al (2016) Suppression of
WHITE COLLAR-independent frequency transcription by histone H3 lysine 36 methyltransferase SET-2 is necessary for clock function in
Neurospora. J Biol Chem 291:11055–11063
Talbert PB, Henikoff S (2010) Histone variants—
ancient wrap artists of the epigenome. Nat Rev
Mol Cell Biol 11:264–275
Tamaru H, Selker EU (2001) A histone H3 methyltransferase controls DNA methylation in Neurospora
crassa. Nature 414:277–283
Tamaru H, Selker EU (2003) Synthesis of signals for de
novo DNA methylation in Neurospora crassa. Mol
Cell Biol 23:2379–2394
Tamaru H, Zhang X, McMillen D et al (2003) Trimethylated lysine 9 of histone H3 is a mark for DNA
methylation in Neurospora crassa. Nat Genet
34:75–79
Trojer P, Reinberg D (2007) Facultative heterochromatin: is there a distinctive molecular signature? Mol
Cell 28:1–13
Verdone L, Caserta M, Di Mauro E (2005) Role of
histone acetylation in the control of gene expression. Biochem Cell Biol 83:344–353
Wang Y, Dong Q, Ding Z et al (2016) Regulation of
Neurospora catalase-3 by global heterochromatin
formation and its proximal heterochromatin
region. Free Radic Biol Med 99:139–152
Wang B, Kettenbach AN, Gerber SA et al (2014) Neurospora WC-1 recruits SWI/SNF to remodel frequency and initiate a circadian cycle. PLoS Genet
10:e1004599
Wang Y, Smith KM, Taylor JW, et al (2015) Endogenous small RNA mediates meiotic silencing of a
novel DNA transposon. G3 5:1949–1960
Wendte JM, Pikaard CS (2017) The RNAs of RNAdirected DNA methylation. Biochim Biophys Acta
Gene Regul Mech 1860:140–148
Xiong L, Adhvaryu KK, Selker EU, Wang Y (2010)
Mapping of lysine methylation and acetylation in
core histones of Neurospora crassa. Biochemistry
49:5236–5243
Xu H, Wang J, Hu Q et al (2010) DCAF26, an adaptor
protein of Cul4-based E3, is essential for DNA
methylation in Neurospora crassa. PLoS Genet 6:
e1001132
Xue Z, Ye Q, Anson SR et al (2014) Transcriptional
interference by antisense RNA is required for circadian clock function. Nature 514:650–653
Yang Z, Qian S, Scheid RN et al (2018) EBS is a bivalent
histone reader that regulates floral phase transition in Arabidopsis. Nat Genet 50:1247–1253
Zacharias H (1995) Emil Heitz (1892-1965): chloroplasts, heterochromatin, and polytene chromosomes. Genetics 141:7–14
Zhang X, Tamaru H, Khan SI et al (2002) Structure of
the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase. Cell 111:117–127
Zhang X, Yang Z, Khan SI et al (2003) Structural basis
for the product specificity of histone lysine
methyltransferases. Mol Cell 12:177–185
Zhao Y, Shen Y, Yang S et al (2010) Ubiquitin ligase
components Cullin4 and DDB1 are essential for
DNA methylation in Neurospora crassa. J Biol
Chem 285:4355–4365
Zhou Y, Cambareri EB, Kinsey JA (2001) DNA methylation inhibits expression and transposition of the
Neurospora tad retrotransposon. Mol Gen Genomics 265:748–754
Zhou Z, Liu X, Hu Q et al (2013) Suppression of WCindependent frequency transcription by RCO-1 is
essential for Neurospora circadian clock. Proc Natl
Acad Sci U S A 110:E4867–E4874
Zhu Q, Ramakrishnan M, Park J, Belden WJ (2019)
Histone H3 lysine 4 methyltransferase is required
for facultative heterochromatin at specific loci.
BMC Genomics 20:350
Zou JX, Revenko AS, Li LB et al (2007) ANCCA, an
estrogen-regulated AAA+ ATPase coactivator for
ERalpha, is required for coregulator occupancy
and chromatin modification. Proc Natl Acad Sci
U S A 104:18067–18072
24
A. J. Courtney et al.