Salichos L, Rokas A (2010) The diversity and evolution
of circadian clock proteins in fungi. Mycologia
102:269–278
Salinas F, Rojas V, Delgado V et al (2017) Optogenetic
switches for light-controlled gene expression in
yeast. Appl Microbiol Biotechnol 101:2629–2640
Salinas F, Rojas V, Delgado V et al (2018) Fungal lightoxygen-voltage domains for optogenetic control of
gene expression and flocculation in yeast. MBio 9:
e00626-18
Sawa M, Nusinow DA, Kay SA, Imaizumi T (2007) FKF1
and GIGANTEA complex formation is required for
day-length measurement in Arabidopsis. Science
318:261–265
Schmidt D, Cho YK (2015) Natural photoreceptors and
their application to synthetic biology. Trends Biotechnol 33:80–91
Schmoll M (2018) Regulation of plant cell wall degradation by light in Trichoderma. Fungal Biol Biotechnol 5:10
Schmoll M, Franchi L, Kubicek CP (2005) Envoy, a
PAS/LOV domain protein of Hypocrea jecorina
(Anamorph Trichoderma reesei), modulates cellulase gene transcription in response to light. Eukaryot Cell 4:1998–2007
Schumacher J (2012) Tools for Botrytis cinerea: new
expression vectors make the gray mold fungus
more accessible to cell biology approaches. Fungal
Genet Biol 49:483–497
Schumacher J (2017) How light affects the life of Botrytis. Fungal Genet Biol 106:26–41
Schwerdtfeger C, Linden H (2003) VIVID is a flavoprotein and serves as a fungal blue light photoreceptor
for photoadaptation. EMBO J 22:4846–4855
Sebille S, Ayad O, Chapotte-Baldacci CA et al (2017)
Optogenetic approach for targeted activation of
global calcium transients in differentiated C2C12
myotubes. Sci Rep 7:11108
Seibel C, Tisch D, Kubicek CP, Schmoll M (2012)
ENVOY is a major determinant in regulation of
sexual development in Hypocrea jecorina (Trichoderma reesei). Eukaryot Cell 11:885–895
Shcherbakova DM, Shemetov AA, Kaberniuk AA, Verkhusha VV (2015) Natural photoreceptors as a
source of fluorescent proteins, biosensors, and
optogenetic tools. Annu Rev Biochem 84:519–550
Shimizu-Sato S, Huq E, Tepperman JM, Quail PH
(2002) A light-switchable gene promoter system.
Nat Biotechnol 20:1041–1044
Sorokina O, Kapus A, Terecskei K et al (2009) A switchable light-input, light-output system modelled and
constructed in yeast. J Biol Eng 3:15
Strickland D, Lin Y, Wagner E et al (2012) TULIPs:
tunable, light-controlled interacting protein tags
for cell biology. Nat Methods 9:379–384
Swartz TE, Corchnoy SB, Christie JM et al (2001) The
photocycle of a flavin-binding domain of the blue
light photoreceptor phototropin. J Biol Chem
276:36493–36500
Taslimi A, Vrana JD, Chen D et al (2014) An optimized
optogenetic clustering tool for probing protein
interaction and function. Nat Commun 5:4925
Verma R, Annan RS, Huddleston MJ et al (1997) Phosphorylation of Sic1p by G1 Cdk required for its
degradation and entry into S phase. Science
278:455–460
Wang X, Chen X, Yang Y (2012) Spatiotemporal control
of gene expression by a light-switchable transgene
system. Nat Methods 9:266–269
Wang W, Shi XY, Wei DZ (2014) Light-mediated control of gene expression in filamentous fungus Trichoderma reesei. J Microbiol Methods 103:37–39
Weissleder R, Ntziachristos V (2003) Shedding light
onto live molecular targets. Nat Med 9:123–128
Yang X, Lau KY, Sevim V, Tang C (2013) Design principles of the yeast G1/S switch. PLoS Biol 11:e1001673
Yazawa M, Sadaghiani AM, Hsueh B, Dolmetsch RE
(2009) Induction of protein-protein interactions
in live cells using light. Nat Biotechnol 27:941–945
Yin R, Ulm R (2017) How plants cope with UV-B: from
perception to response. Curr Opin Plant Biol
37:42–48
Yin C, Fan X, Ma K et al (2019) Identification and
characterization of a novel light-induced promoter
for recombinant protein production in Pleurotus
ostreatus. J Microbiol 58(1):39–45
Zhang K, Cui B (2015) Optogenetic control of intracellular signaling pathways. Trends Biotechnol
33:92–100
Zhang G, Liu P, Wei W et al (2016a) A light-switchable
bidirectional expression system in filamentous
fungus Trichoderma reesei. J Biotechnol 240:85–93
Zhang L, Zhao X, Zhang G et al (2016b) Light-inducible
genetic engineering and control of non-homologous
end-joining in industrial eukaryotic microorganisms: LML 3.0 and OFN 1.0. Sci Rep 6:20761
Zhao EM, Zhang Y, Mehl J et al (2018) Optogenetic
regulation of engineered cellular metabolism
for microbial chemical production. Nature
555:683–687
Zoltowski BD, Motta-Mena LB, Gardner KH (2013)
Blue light-induced dimerization of a bacterial
LOV-HTH DNA-binding protein. Biochemistry
52:6653–6661
318
V. Rojas et al.
of circadian clock proteins in fungi. Mycologia
102:269–278
Salinas F, Rojas V, Delgado V et al (2017) Optogenetic
switches for light-controlled gene expression in
yeast. Appl Microbiol Biotechnol 101:2629–2640
Salinas F, Rojas V, Delgado V et al (2018) Fungal lightoxygen-voltage domains for optogenetic control of
gene expression and flocculation in yeast. MBio 9:
e00626-18
Sawa M, Nusinow DA, Kay SA, Imaizumi T (2007) FKF1
and GIGANTEA complex formation is required for
day-length measurement in Arabidopsis. Science
318:261–265
Schmidt D, Cho YK (2015) Natural photoreceptors and
their application to synthetic biology. Trends Biotechnol 33:80–91
Schmoll M (2018) Regulation of plant cell wall degradation by light in Trichoderma. Fungal Biol Biotechnol 5:10
Schmoll M, Franchi L, Kubicek CP (2005) Envoy, a
PAS/LOV domain protein of Hypocrea jecorina
(Anamorph Trichoderma reesei), modulates cellulase gene transcription in response to light. Eukaryot Cell 4:1998–2007
Schumacher J (2012) Tools for Botrytis cinerea: new
expression vectors make the gray mold fungus
more accessible to cell biology approaches. Fungal
Genet Biol 49:483–497
Schumacher J (2017) How light affects the life of Botrytis. Fungal Genet Biol 106:26–41
Schwerdtfeger C, Linden H (2003) VIVID is a flavoprotein and serves as a fungal blue light photoreceptor
for photoadaptation. EMBO J 22:4846–4855
Sebille S, Ayad O, Chapotte-Baldacci CA et al (2017)
Optogenetic approach for targeted activation of
global calcium transients in differentiated C2C12
myotubes. Sci Rep 7:11108
Seibel C, Tisch D, Kubicek CP, Schmoll M (2012)
ENVOY is a major determinant in regulation of
sexual development in Hypocrea jecorina (Trichoderma reesei). Eukaryot Cell 11:885–895
Shcherbakova DM, Shemetov AA, Kaberniuk AA, Verkhusha VV (2015) Natural photoreceptors as a
source of fluorescent proteins, biosensors, and
optogenetic tools. Annu Rev Biochem 84:519–550
Shimizu-Sato S, Huq E, Tepperman JM, Quail PH
(2002) A light-switchable gene promoter system.
Nat Biotechnol 20:1041–1044
Sorokina O, Kapus A, Terecskei K et al (2009) A switchable light-input, light-output system modelled and
constructed in yeast. J Biol Eng 3:15
Strickland D, Lin Y, Wagner E et al (2012) TULIPs:
tunable, light-controlled interacting protein tags
for cell biology. Nat Methods 9:379–384
Swartz TE, Corchnoy SB, Christie JM et al (2001) The
photocycle of a flavin-binding domain of the blue
light photoreceptor phototropin. J Biol Chem
276:36493–36500
Taslimi A, Vrana JD, Chen D et al (2014) An optimized
optogenetic clustering tool for probing protein
interaction and function. Nat Commun 5:4925
Verma R, Annan RS, Huddleston MJ et al (1997) Phosphorylation of Sic1p by G1 Cdk required for its
degradation and entry into S phase. Science
278:455–460
Wang X, Chen X, Yang Y (2012) Spatiotemporal control
of gene expression by a light-switchable transgene
system. Nat Methods 9:266–269
Wang W, Shi XY, Wei DZ (2014) Light-mediated control of gene expression in filamentous fungus Trichoderma reesei. J Microbiol Methods 103:37–39
Weissleder R, Ntziachristos V (2003) Shedding light
onto live molecular targets. Nat Med 9:123–128
Yang X, Lau KY, Sevim V, Tang C (2013) Design principles of the yeast G1/S switch. PLoS Biol 11:e1001673
Yazawa M, Sadaghiani AM, Hsueh B, Dolmetsch RE
(2009) Induction of protein-protein interactions
in live cells using light. Nat Biotechnol 27:941–945
Yin R, Ulm R (2017) How plants cope with UV-B: from
perception to response. Curr Opin Plant Biol
37:42–48
Yin C, Fan X, Ma K et al (2019) Identification and
characterization of a novel light-induced promoter
for recombinant protein production in Pleurotus
ostreatus. J Microbiol 58(1):39–45
Zhang K, Cui B (2015) Optogenetic control of intracellular signaling pathways. Trends Biotechnol
33:92–100
Zhang G, Liu P, Wei W et al (2016a) A light-switchable
bidirectional expression system in filamentous
fungus Trichoderma reesei. J Biotechnol 240:85–93
Zhang L, Zhao X, Zhang G et al (2016b) Light-inducible
genetic engineering and control of non-homologous
end-joining in industrial eukaryotic microorganisms: LML 3.0 and OFN 1.0. Sci Rep 6:20761
Zhao EM, Zhang Y, Mehl J et al (2018) Optogenetic
regulation of engineered cellular metabolism
for microbial chemical production. Nature
555:683–687
Zoltowski BD, Motta-Mena LB, Gardner KH (2013)
Blue light-induced dimerization of a bacterial
LOV-HTH DNA-binding protein. Biochemistry
52:6653–6661
318
V. Rojas et al.