Skinnider MA, Dejong CA, Rees PN et al (2015) Genomes to natural products PRediction Informatics
for Secondary Metabolomes (PRISM). Nucleic
Acids Res. https://doi.org/10.1093/nar/gkv1012
Sondergaard TE, Hansen FT, Purup S et al (2011)
Fusarin C acts like an estrogenic agonist and
stimulates breast cancer cells in vitro. Toxicol
Lett 205:116–121. https://doi.org/10.1016/j.toxlet.2011.05.1029
Spraker JE, Jewell K, Roze LV et al (2014) A volatile
relationship: profiling an inter-kingdom dialogue
between two plant pathogens, Ralstonia solanacearum and Aspergillus flavus. J Chem Ecol
40:502–513. https://doi.org/10.1007/s10886-0140432-2
Starcevic A, Zucko J, Simunkovic J et al (2008) ClustScan: an integrated program package for the semiautomatic annotation of modular biosynthetic
gene clusters and in silico prediction of novel
chemical structures. Nucleic Acids Res 36:6882–
6892. https://doi.org/10.1093/nar/gkn685
Stierle AA, Stierle DB, Decato D et al (2017) The berkeleylactones, antibiotic macrolides from fungal
coculture. J Nat Prod 80:1150–1160. https://doi.
org/10.1021/acs.jnatprod.7b00133
Subramanian V, Schuster LA, Moore KT et al (2017) A
versatile 2A peptide-based bicistronic protein
expressing platform for the industrial cellulase
producing fungus, Trichoderma reesei. Biotechnol
Biofuels 10:34. https://doi.org/10.1186/s13068017-0710-7
Sun WW, Guo C-J, Wang CCC (2016) Characterization
of the product of a nonribosomal peptide
synthetase-like (NRPS-like) gene using the doxycycline dependent Tet-on system in Aspergillus
terreus. Fungal Genet Biol 89:84–88. https://doi.
org/10.1016/j.fgb.2016.01.014
Suzuki S, Hosoe T, Nozawa K et al (2000) Antifungal
substances against pathogenic fungi, talaroconvolutins, from Talaromyces convolutus. J Nat Prod
63:768–772. https://doi.org/10.1021/np990371x
Tagami K, Minami A, Fujii R et al (2014) Rapid reconstitution of biosynthetic machinery for fungal
metabolites in Aspergillus oryzae: total biosynthesis of aflatrem. Chembiochem 15:2076–2080.
https://doi.org/10.1002/cbic.201402195
Takahashi C, Matsushita T, Doi M et al (1995) Fumiquinazolines A–G, novel metabolites of a fungus
separated from a Pseudolabrus marine fish. J Chem
Soc Perkin Trans 1 18:2345–2353. https://doi.org/
10.1039/P19950002345
Takeda I, Umemura M, Koike H et al (2014) Motifindependent prediction of a secondary metabolism gene cluster using comparative genomics:
application to sequenced genomes of Aspergillus
and ten other filamentous fungal species. DNA Res
21:447–457. https://doi.org/10.1093/dnares/dsu010
Tauber JP, Schroeckh V, Shelest E et al (2016) Bacteria
induce pigment formation in the basidiomycete
Serpula lacrymans. Environ Microbiol 18:5218–
5227. https://doi.org/10.1111/1462-2920.13558
Tauber JP, Gallegos-Monterrosa R, Kova ´cs A ´ T et al
(2018) Dissimilar pigment regulation in Serpula
lacrymans and Paxillus involutus during interkingdom interactions. Microbiology 164:65–77.
https://doi.org/10.1099/mic.0.000582
Ugai T, Minami A, Gomi K, Oikawa H (2016) Genome
mining approach for harnessing the cryptic gene
cluster in Alternaria solani: production of PKS–
NRPS hybrid metabolite, didymellamide B. Tetrahedron Lett 57:2793–2796. https://doi.org/10.1016/
j.tetlet.2016.05.043
Unkles SE, Valiante V, Mattern DJ, Brakhage AA (2014)
Synthetic biology tools for bioprospecting of natural products in eukaryotes. Chem Biol 21:502–
508.
https://doi.org/10.1016/j.chembiol.2014.02.010
Valiante V (2017) The cell wall integrity signaling pathway and its involvement in secondary metabolite
production. J Fungi 3:68. https://doi.org/10.3390/
jof3040068
van Dijk JWA, Guo CJ, Wang CCC (2016) Engineering
fungal nonribosomal peptide synthetase-like
enzymes by heterologous expression and domain
swapping. Org Lett 18:6236–6239. https://doi.org/
10.1021/acs.orglett.6b02821
Vansteelandt M, Kerzaon I, Blanchet E et al (2012)
Patulin and secondary metabolite production by
marine-derived Penicillium strains. Fungal Biol
116:954–961.
https://doi.org/10.1016/j.funbio.2012.06.005
Vo ¨disch M, Scherlach K, Winkler R et al (2011) Analysis of the Aspergillus fumigatus proteome reveals
metabolic changes and the activation of the pseurotin a biosynthesis gene cluster in response to
hypoxia. J Proteome Res 10:2508–2524. https://
doi.org/10.1021/pr1012812
Vogt K, Bhabhra R, Rhodes JC, Askew DS (2005)
Doxycycline-regulated gene expression in the
opportunistic fungal pathogen Aspergillus fumigatus. BMC Microbiol 5:1. https://doi.org/10.1186/
1471-2180-5-1
Vyas VK, Barrasa MI, Fink GR (2015) A Candida albicans CRISPR system permits genetic engineering
of essential genes and gene families. Sci Adv 1:
e1500248. https://doi.org/10.1126/sciadv.1500248
Wakefield J, Hassan HM, Jaspars M et al (2017) Dual
induction of new microbial secondary metabolites
by fungal bacterial co-cultivation. Front Microbiol
8:1284. https://doi.org/10.3389/fmicb.2017.01284
Wang L (2003) Control of growth, secondary metabolism and sporulation in Streptomyces venezuelae
ISP5230 by jadW1, a member of the afsA family of
gamma-butyrolactone regulatory genes. Microbiology 149:1991–2004. https://doi.org/10.1099/
mic.0.26209-0
Wang DZ, Kong LF, Li YY, Xie ZX (2016a) Environmental microbial community proteomics: status,
11 New Avenues Toward Drug Discovery in Fungi
293
for Secondary Metabolomes (PRISM). Nucleic
Acids Res. https://doi.org/10.1093/nar/gkv1012
Sondergaard TE, Hansen FT, Purup S et al (2011)
Fusarin C acts like an estrogenic agonist and
stimulates breast cancer cells in vitro. Toxicol
Lett 205:116–121. https://doi.org/10.1016/j.toxlet.2011.05.1029
Spraker JE, Jewell K, Roze LV et al (2014) A volatile
relationship: profiling an inter-kingdom dialogue
between two plant pathogens, Ralstonia solanacearum and Aspergillus flavus. J Chem Ecol
40:502–513. https://doi.org/10.1007/s10886-0140432-2
Starcevic A, Zucko J, Simunkovic J et al (2008) ClustScan: an integrated program package for the semiautomatic annotation of modular biosynthetic
gene clusters and in silico prediction of novel
chemical structures. Nucleic Acids Res 36:6882–
6892. https://doi.org/10.1093/nar/gkn685
Stierle AA, Stierle DB, Decato D et al (2017) The berkeleylactones, antibiotic macrolides from fungal
coculture. J Nat Prod 80:1150–1160. https://doi.
org/10.1021/acs.jnatprod.7b00133
Subramanian V, Schuster LA, Moore KT et al (2017) A
versatile 2A peptide-based bicistronic protein
expressing platform for the industrial cellulase
producing fungus, Trichoderma reesei. Biotechnol
Biofuels 10:34. https://doi.org/10.1186/s13068017-0710-7
Sun WW, Guo C-J, Wang CCC (2016) Characterization
of the product of a nonribosomal peptide
synthetase-like (NRPS-like) gene using the doxycycline dependent Tet-on system in Aspergillus
terreus. Fungal Genet Biol 89:84–88. https://doi.
org/10.1016/j.fgb.2016.01.014
Suzuki S, Hosoe T, Nozawa K et al (2000) Antifungal
substances against pathogenic fungi, talaroconvolutins, from Talaromyces convolutus. J Nat Prod
63:768–772. https://doi.org/10.1021/np990371x
Tagami K, Minami A, Fujii R et al (2014) Rapid reconstitution of biosynthetic machinery for fungal
metabolites in Aspergillus oryzae: total biosynthesis of aflatrem. Chembiochem 15:2076–2080.
https://doi.org/10.1002/cbic.201402195
Takahashi C, Matsushita T, Doi M et al (1995) Fumiquinazolines A–G, novel metabolites of a fungus
separated from a Pseudolabrus marine fish. J Chem
Soc Perkin Trans 1 18:2345–2353. https://doi.org/
10.1039/P19950002345
Takeda I, Umemura M, Koike H et al (2014) Motifindependent prediction of a secondary metabolism gene cluster using comparative genomics:
application to sequenced genomes of Aspergillus
and ten other filamentous fungal species. DNA Res
21:447–457. https://doi.org/10.1093/dnares/dsu010
Tauber JP, Schroeckh V, Shelest E et al (2016) Bacteria
induce pigment formation in the basidiomycete
Serpula lacrymans. Environ Microbiol 18:5218–
5227. https://doi.org/10.1111/1462-2920.13558
Tauber JP, Gallegos-Monterrosa R, Kova ´cs A ´ T et al
(2018) Dissimilar pigment regulation in Serpula
lacrymans and Paxillus involutus during interkingdom interactions. Microbiology 164:65–77.
https://doi.org/10.1099/mic.0.000582
Ugai T, Minami A, Gomi K, Oikawa H (2016) Genome
mining approach for harnessing the cryptic gene
cluster in Alternaria solani: production of PKS–
NRPS hybrid metabolite, didymellamide B. Tetrahedron Lett 57:2793–2796. https://doi.org/10.1016/
j.tetlet.2016.05.043
Unkles SE, Valiante V, Mattern DJ, Brakhage AA (2014)
Synthetic biology tools for bioprospecting of natural products in eukaryotes. Chem Biol 21:502–
508.
https://doi.org/10.1016/j.chembiol.2014.02.010
Valiante V (2017) The cell wall integrity signaling pathway and its involvement in secondary metabolite
production. J Fungi 3:68. https://doi.org/10.3390/
jof3040068
van Dijk JWA, Guo CJ, Wang CCC (2016) Engineering
fungal nonribosomal peptide synthetase-like
enzymes by heterologous expression and domain
swapping. Org Lett 18:6236–6239. https://doi.org/
10.1021/acs.orglett.6b02821
Vansteelandt M, Kerzaon I, Blanchet E et al (2012)
Patulin and secondary metabolite production by
marine-derived Penicillium strains. Fungal Biol
116:954–961.
https://doi.org/10.1016/j.funbio.2012.06.005
Vo ¨disch M, Scherlach K, Winkler R et al (2011) Analysis of the Aspergillus fumigatus proteome reveals
metabolic changes and the activation of the pseurotin a biosynthesis gene cluster in response to
hypoxia. J Proteome Res 10:2508–2524. https://
doi.org/10.1021/pr1012812
Vogt K, Bhabhra R, Rhodes JC, Askew DS (2005)
Doxycycline-regulated gene expression in the
opportunistic fungal pathogen Aspergillus fumigatus. BMC Microbiol 5:1. https://doi.org/10.1186/
1471-2180-5-1
Vyas VK, Barrasa MI, Fink GR (2015) A Candida albicans CRISPR system permits genetic engineering
of essential genes and gene families. Sci Adv 1:
e1500248. https://doi.org/10.1126/sciadv.1500248
Wakefield J, Hassan HM, Jaspars M et al (2017) Dual
induction of new microbial secondary metabolites
by fungal bacterial co-cultivation. Front Microbiol
8:1284. https://doi.org/10.3389/fmicb.2017.01284
Wang L (2003) Control of growth, secondary metabolism and sporulation in Streptomyces venezuelae
ISP5230 by jadW1, a member of the afsA family of
gamma-butyrolactone regulatory genes. Microbiology 149:1991–2004. https://doi.org/10.1099/
mic.0.26209-0
Wang DZ, Kong LF, Li YY, Xie ZX (2016a) Environmental microbial community proteomics: status,
11 New Avenues Toward Drug Discovery in Fungi
293