de Borges W, Borges K, Bonato P et al (2009)
Endophytic fungi: natural products, enzymes
and biotransformation reactions. Curr Org
Chem 13:1137–1163. https://doi.org/10.2174/
138527209788921783
de Vries RP, Riley R, Wiebenga A et al (2017) Comparative genomics reveals high biological diversity
and specific adaptations in the industrially and
medically important fungal genus Aspergillus.
Genome Biol 18:28. https://doi.org/10.1186/
s13059-017-1151-0
Degenkolb T, Heinze S, Schlegel B et al (2002) Formation of new lipoaminopeptides, acremostatins A,
B, and C, by co-cultivation of Acremonium sp.
Tbp-5 and Mycogone rosea DSM 12973. Biosci
Biotechnol Biochem 66:883–886
Deng H, Gao R, Liao X, Cai Y (2017) CRISPR system in
filamentous fungi: current achievements and
future directions. Gene 627:212–221. https://doi.
org/10.1016/j.gene.2017.06.019
Dhodary B, Schilg M, Wirth R, Spiteller D (2018) Secondary metabolites from Escovopsis weberi and
their role in attacking the garden fungus of leafcutting ants. Chem A Eur J 24:4445–4452. https://
doi.org/10.1002/chem.201706071
Du C, van Wezel GP (2018) Mining for microbial gems:
integrating proteomics in the postgenomic natural
product discovery pipeline. Proteomics 18:1700332.
https://doi.org/10.1002/pmic.201700332
Du FY, Li XM, Zhang P et al (2014) Cyclodepsipeptides
and other O-containing heterocyclic metabolites
from Beauveria felina EN-135, a marine-derived
entomopathogenic fungus. Mar Drugs 12:2816–
2826. https://doi.org/10.3390/md12052816
Evans JA, Eyre CA, Rogers HJ et al (2008) Changes in
volatile production during interspecific interactions between four wood rotting fungi growing in
artificial media. Fungal Ecol 1:57–68. https://doi.
org/10.1016/j.funeco.2008.06.001
Fisch KM, Bakeer W, Yakasai AA et al (2011) Rational
domain swaps decipher programming in fungal
highly reducing polyketide synthases and resurrect
an extinct metabolite. J Am Chem Soc 133:16635–
16641. https://doi.org/10.1021/ja206914q
Fischbach MA, Lai JR, Roche ED et al (2007) Directed
evolution can rapidly improve the activity of chimeric assembly-line enzymes. Proc Natl Acad Sci
USA 104:11951–11956. https://doi.org/10.1073/
pnas.0705348104
Fischer J, Mu ¨ller SY, Netzker T et al (2018) Chromatin
mapping identifies BasR, a key regulator of
bacteria-triggered production of fungal secondary
metabolites. eLife 7:e40969. https://doi.org/
10.7554/eLife.40969
Forsberg EM, Huan T, Rinehart D et al (2018) Data
processing, multi-omic pathway mapping, and
metabolite activity analysis using XCMS Online.
Nat Protoc 13:633–651. https://doi.org/10.1038/
nprot.2017.151
Fuller KK, Chen S, Loros JJ, Dunlap JC (2015) Development of the CRISPR/Cas9 system for targeted
gene disruption in Aspergillus fumigatus. Eukaryot Cell 14:1073–1080. https://doi.org/10.1128/
EC.00107-15
Galanie S, Thodey K, Trenchard IJ et al (2015) Complete biosynthesis of opioids in yeast. Science 349
(6252):1095–1100. https://doi.org/10.1126/science.
aac9373
Gao J, Tarcea VG, Karnovsky A et al (2010) Metscape: a
Cytoscape plug-in for visualizing and interpreting
metabolomic data in the context of human metabolic networks. Bioinformatics 26:971–973.
https://doi.org/10.1093/bioinformatics/btq048
Garcı ´a-Estrada C, Domı ´nguez-Santos R, Kosalkova ´ K,
Martı ´n JF (2018) Transcription factors controlling
primary and secondary metabolism in filamentous
fungi: the b-Lactam paradigm. Fermentation 4:47.
https://doi.org/10.3390/fermentation4020047
Geib E, Brock M (2017) ATNT: an enhanced system for
expression of polycistronic secondary metabolite
gene clusters in Aspergillus niger. Fungal Biol Biotechnol 4:13. https://doi.org/10.1186/s40694-0170042-1
Goudie AC, Evans NA, Gration KAF et al (1993) Doramectin—a potent novel endectocide. Vet Parasitol 49:5–15. https://doi.org/10.1016/0304-4017(93)
90218-C
Grapov D, Wanichthanarak K, Fiehn O (2015) MetaMapR: pathway independent metabolomic network
analysis incorporating unknowns. Bioinformatics
31:2757–2760. https://doi.org/10.1093/bioinformatics/btv194
Grau MF, Entwistle R, Chiang Y-M et al (2018) Hybrid
transcription factor engineering activates the
silent secondary metabolite gene cluster for (+)asperlin in Aspergillus nidulans. ACS Chem Biol
13:3193–3205. https://doi.org/10.1021/acschembio.8b00679D
Gressler M, Hortschansky P, Geib E, Brock M (2015) A
new high-performance heterologous fungal
expression system based on regulatory elements
from the Aspergillus terreus terrein gene cluster.
Front Microbiol 6:184. https://doi.org/10.3389/
fmicb.2015.00184
Griffiths RR, Johnson MW, Carducci MA et al (2016)
Psilocybin produces substantial and sustained
decreases in depression and anxiety in patients
with life-threatening cancer: a randomized
double-blind trial. J Psychopharmacol 30:1181–
1197. https://doi.org/10.1177/0269881116675513
Gubbens J, Zhu H, Girard G et al (2014) Natural product proteomining, a quantitative proteomics platform, allows rapid discovery of biosynthetic gene
clusters for different classes of natural products.
Chem Biol 21:707–718. https://doi.org/10.1016/j.
chembiol.2014.03.011
Haeder S, Wirth R, Herz H, Spiteller D (2009)
Candicidin-producing Streptomyces support leaf11 New Avenues Toward Drug Discovery in Fungi
289
Endophytic fungi: natural products, enzymes
and biotransformation reactions. Curr Org
Chem 13:1137–1163. https://doi.org/10.2174/
138527209788921783
de Vries RP, Riley R, Wiebenga A et al (2017) Comparative genomics reveals high biological diversity
and specific adaptations in the industrially and
medically important fungal genus Aspergillus.
Genome Biol 18:28. https://doi.org/10.1186/
s13059-017-1151-0
Degenkolb T, Heinze S, Schlegel B et al (2002) Formation of new lipoaminopeptides, acremostatins A,
B, and C, by co-cultivation of Acremonium sp.
Tbp-5 and Mycogone rosea DSM 12973. Biosci
Biotechnol Biochem 66:883–886
Deng H, Gao R, Liao X, Cai Y (2017) CRISPR system in
filamentous fungi: current achievements and
future directions. Gene 627:212–221. https://doi.
org/10.1016/j.gene.2017.06.019
Dhodary B, Schilg M, Wirth R, Spiteller D (2018) Secondary metabolites from Escovopsis weberi and
their role in attacking the garden fungus of leafcutting ants. Chem A Eur J 24:4445–4452. https://
doi.org/10.1002/chem.201706071
Du C, van Wezel GP (2018) Mining for microbial gems:
integrating proteomics in the postgenomic natural
product discovery pipeline. Proteomics 18:1700332.
https://doi.org/10.1002/pmic.201700332
Du FY, Li XM, Zhang P et al (2014) Cyclodepsipeptides
and other O-containing heterocyclic metabolites
from Beauveria felina EN-135, a marine-derived
entomopathogenic fungus. Mar Drugs 12:2816–
2826. https://doi.org/10.3390/md12052816
Evans JA, Eyre CA, Rogers HJ et al (2008) Changes in
volatile production during interspecific interactions between four wood rotting fungi growing in
artificial media. Fungal Ecol 1:57–68. https://doi.
org/10.1016/j.funeco.2008.06.001
Fisch KM, Bakeer W, Yakasai AA et al (2011) Rational
domain swaps decipher programming in fungal
highly reducing polyketide synthases and resurrect
an extinct metabolite. J Am Chem Soc 133:16635–
16641. https://doi.org/10.1021/ja206914q
Fischbach MA, Lai JR, Roche ED et al (2007) Directed
evolution can rapidly improve the activity of chimeric assembly-line enzymes. Proc Natl Acad Sci
USA 104:11951–11956. https://doi.org/10.1073/
pnas.0705348104
Fischer J, Mu ¨ller SY, Netzker T et al (2018) Chromatin
mapping identifies BasR, a key regulator of
bacteria-triggered production of fungal secondary
metabolites. eLife 7:e40969. https://doi.org/
10.7554/eLife.40969
Forsberg EM, Huan T, Rinehart D et al (2018) Data
processing, multi-omic pathway mapping, and
metabolite activity analysis using XCMS Online.
Nat Protoc 13:633–651. https://doi.org/10.1038/
nprot.2017.151
Fuller KK, Chen S, Loros JJ, Dunlap JC (2015) Development of the CRISPR/Cas9 system for targeted
gene disruption in Aspergillus fumigatus. Eukaryot Cell 14:1073–1080. https://doi.org/10.1128/
EC.00107-15
Galanie S, Thodey K, Trenchard IJ et al (2015) Complete biosynthesis of opioids in yeast. Science 349
(6252):1095–1100. https://doi.org/10.1126/science.
aac9373
Gao J, Tarcea VG, Karnovsky A et al (2010) Metscape: a
Cytoscape plug-in for visualizing and interpreting
metabolomic data in the context of human metabolic networks. Bioinformatics 26:971–973.
https://doi.org/10.1093/bioinformatics/btq048
Garcı ´a-Estrada C, Domı ´nguez-Santos R, Kosalkova ´ K,
Martı ´n JF (2018) Transcription factors controlling
primary and secondary metabolism in filamentous
fungi: the b-Lactam paradigm. Fermentation 4:47.
https://doi.org/10.3390/fermentation4020047
Geib E, Brock M (2017) ATNT: an enhanced system for
expression of polycistronic secondary metabolite
gene clusters in Aspergillus niger. Fungal Biol Biotechnol 4:13. https://doi.org/10.1186/s40694-0170042-1
Goudie AC, Evans NA, Gration KAF et al (1993) Doramectin—a potent novel endectocide. Vet Parasitol 49:5–15. https://doi.org/10.1016/0304-4017(93)
90218-C
Grapov D, Wanichthanarak K, Fiehn O (2015) MetaMapR: pathway independent metabolomic network
analysis incorporating unknowns. Bioinformatics
31:2757–2760. https://doi.org/10.1093/bioinformatics/btv194
Grau MF, Entwistle R, Chiang Y-M et al (2018) Hybrid
transcription factor engineering activates the
silent secondary metabolite gene cluster for (+)asperlin in Aspergillus nidulans. ACS Chem Biol
13:3193–3205. https://doi.org/10.1021/acschembio.8b00679D
Gressler M, Hortschansky P, Geib E, Brock M (2015) A
new high-performance heterologous fungal
expression system based on regulatory elements
from the Aspergillus terreus terrein gene cluster.
Front Microbiol 6:184. https://doi.org/10.3389/
fmicb.2015.00184
Griffiths RR, Johnson MW, Carducci MA et al (2016)
Psilocybin produces substantial and sustained
decreases in depression and anxiety in patients
with life-threatening cancer: a randomized
double-blind trial. J Psychopharmacol 30:1181–
1197. https://doi.org/10.1177/0269881116675513
Gubbens J, Zhu H, Girard G et al (2014) Natural product proteomining, a quantitative proteomics platform, allows rapid discovery of biosynthetic gene
clusters for different classes of natural products.
Chem Biol 21:707–718. https://doi.org/10.1016/j.
chembiol.2014.03.011
Haeder S, Wirth R, Herz H, Spiteller D (2009)
Candicidin-producing Streptomyces support leaf11 New Avenues Toward Drug Discovery in Fungi
289