genes in filamentous fungi. Appl Microbiol Biotechnol 98:3859–3867
Taylor DL, Hollingsworth TN, McFarland JW, Lennon
NJ, Nusbaum C, Ruess RW (2014) A first comprehensive census of fungi in soil reveals both hyperdiversity and fine-scale niche partitioning. Ecol
Monogr 84:3–20
Throndset W, Kim S, Bower B, Lantz S, Kelemen B,
Pepsin M, Chow N, Mitchinson C, Ward M
(2010) Flow cytometric sorting of the filamentous
fungus Trichoderma reesei for improved strains.
Enzym Microb Technol 47:335–341
Tian Y, Tan Y, Liu N, Yan Z, Liao Y, Chen J, De Saeger
S, Yang H, Zhang Q, Wu A (2016) Detoxification of
deoxynivalenol via glycosylation represents novel
insights on antagonistic activities of Trichoderma
when confronted with Fusarium graminearum.
Toxins 8:1–15
Till P, Pucher ME, Mach RL, Mach-Aigner AR (2018) A
long noncoding RNA promotes cellulase expression in Trichoderma reesei. Biotechnol Biofuels
11:1–16
Unkles SE, Campbell EI, Carrez D, Grieve C, Contreras
R, Fiers W, van den Hondel CAMJJ, Kinghorn JR
(1989) Transformation of Aspergillus niger with
the homologous nitrate reductase gene. Gene
78:157–166
Urlinger S, Baron U, Thellmann M, Hasan MT, Bujard
H, Hillen W (2000) Exploring the sequence space
for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and
sensitivity. Proc Natl Acad Sci USA 97:7963–7968
Valkonen M, Ward M, Wang H, Penttila ¨ M, Saloheimo
M (2003) Improvement of foreign-protein production in Aspergillus niger var. awamori by constitutive induction of the unfolded-protein response.
Appl Environ Microbiol 69:6979–6986
van den Brink HJM, Petersen SG, Rahbek-Nielsen H,
Hellmuth K, Harboe M (2006) Increased production of chymosin by glycosylation. J Biotechnol
125:304–310
Vanegas KG, Lehka BJ, Mortensen UH (2017) SWITCH:
a dynamic CRISPR tool for genome engineering
and metabolic pathway control for cell factory
construction in Saccharomyces cerevisiae. Microb
Cell Factories 16:1–12
Vesth TC, Nybo JL, Theobald S, Frisvad JC, Larsen TO,
Nielsen KF, Hoof JB, Brandl J, Salamov A, Riley R,
Gladden JM, Phatale P, Nielsen MT, Lyhne EK,
Kogle ME, Strasser K, McDonnell E, Barry K,
Clum A, Chen C, LaButti K, Haridas S, Nolan M,
Sandor L, Kuo A, Lipzen A, Hainaut M, Drula E,
Tsang A, Magnuson JK, Henrissat B, Wiebenga A,
Simmons BA, Ma ¨kela ¨ MR, de Vries RP, Grigoriev
IV, Mortensen UH, Baker SE, Andersen MR (2018)
Investigation of inter- and intraspecies variation
through genome sequencing of Aspergillus section
Nigri. Nat Genet 50:1688–1695
Vlaardingerbroek I, Beerens B, Shahi S, Rep M (2015)
Fluorescence assisted selection of Transformants
(FAST): using flow cytometry to select fungal
transformants. Fungal Genet Biol 76:104–109
Wang B, Guo G, Wang C, Lin Y, Wang X, Zhao M, Guo
Y, He M, Zhang Y, Pan L (2010) Survey of the
transcriptome of Aspergillus oryzae via massively
parallel mRNA sequencing. Nucleic Acids Res
38:5075–5087
Wanka F, Cairns T, Boecker S, Berens C, Happel A,
Zheng X, Sun J, Krappmann S, Meyer V (2016)
Tet-on, or Tet-off, that is the question: advanced
conditional gene expression in Aspergillus. Fungal
Genet Biol 89:72–83
Ward M, Wilson LJ, Carmona CL, Turner G (1988) The
oliC3 gene of Aspergillus niger: isolation, sequence
and use as a selectable marker for transformation.
Curr Genet 14:37–42
Waring RB, May GS, Morris NR (1989) Characterization of an inducible expression system in Aspergillus nidulans using alcA and tubulin coding genes.
Gene 79:119–130
Watanabe A, Ono Y, Fujii I, Sankawa U, Mayorga ME,
Timberlake WE, Ebizuka Y (1998) Product identification of polyketide synthase coded by Aspergillus nidulans wA gene. Tetrahedron Lett 39:7733–
7736
Watanabe A, Fujii I, Sankawa U, Mayorga ME, Timberlake WE, Ebizuka Y (1999) Re-identification of
Aspergillus nidulans wA gene to code for a polyketide synthase of naphthopyrone. Tetrahedron Lett
40:91–94
Wei W, Chen L, Zou G, Wang Q, Yan X, Zhang J, Wang
C, Zhou Z (2013) N-glycosylation affects the
proper folding, enzymatic characteristics and production of a fungal b-glucosidase. Biotechnol
Bioeng 110:3075–3084
Wernars K, Goosen T, Wennekes LMJ, Visser J, Bos CJ,
van den Broek HWJ, van Gorcom RFM, van den
Hondel CAMJJ, Pouwels PH (1985) Gene amplification in Aspergillus nidulans by transformation
with vectors containing the amdS gene. Curr Genet
9:361–368
Wiemann P, Soukup AA, Folz JS, Wang PM, Noack A,
Keller NP (2018) CoIN:co-inducible nitrate expression system for secondary metabolites in Aspergillus nidulans. Fungal Biol Biotechnol 5:1–10
Willis KJ (ed) (2018) State of the world’s fungi 2018.
Report. Royal Botanic Gardens, Kew
Wu Y, Sun X, Xue X, Luo H, Yao B, Xie X, Su X (2017)
Overexpressing key component genes of the secretion pathway for enhanced secretion of an Aspergillus niger glucose oxidase in Trichoderma reesei.
Enzym Microb Technol 106:83–87
Xie X, Meehan MJ, Xu W, Dorrestein PC, Tang Y (2009)
Acyltransferase mediated polyketide release from
a fungal megasynthase. J Am Chem Soc 131:8388–
8389
264
J. K. H. Rendsvig et al.
Taylor DL, Hollingsworth TN, McFarland JW, Lennon
NJ, Nusbaum C, Ruess RW (2014) A first comprehensive census of fungi in soil reveals both hyperdiversity and fine-scale niche partitioning. Ecol
Monogr 84:3–20
Throndset W, Kim S, Bower B, Lantz S, Kelemen B,
Pepsin M, Chow N, Mitchinson C, Ward M
(2010) Flow cytometric sorting of the filamentous
fungus Trichoderma reesei for improved strains.
Enzym Microb Technol 47:335–341
Tian Y, Tan Y, Liu N, Yan Z, Liao Y, Chen J, De Saeger
S, Yang H, Zhang Q, Wu A (2016) Detoxification of
deoxynivalenol via glycosylation represents novel
insights on antagonistic activities of Trichoderma
when confronted with Fusarium graminearum.
Toxins 8:1–15
Till P, Pucher ME, Mach RL, Mach-Aigner AR (2018) A
long noncoding RNA promotes cellulase expression in Trichoderma reesei. Biotechnol Biofuels
11:1–16
Unkles SE, Campbell EI, Carrez D, Grieve C, Contreras
R, Fiers W, van den Hondel CAMJJ, Kinghorn JR
(1989) Transformation of Aspergillus niger with
the homologous nitrate reductase gene. Gene
78:157–166
Urlinger S, Baron U, Thellmann M, Hasan MT, Bujard
H, Hillen W (2000) Exploring the sequence space
for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and
sensitivity. Proc Natl Acad Sci USA 97:7963–7968
Valkonen M, Ward M, Wang H, Penttila ¨ M, Saloheimo
M (2003) Improvement of foreign-protein production in Aspergillus niger var. awamori by constitutive induction of the unfolded-protein response.
Appl Environ Microbiol 69:6979–6986
van den Brink HJM, Petersen SG, Rahbek-Nielsen H,
Hellmuth K, Harboe M (2006) Increased production of chymosin by glycosylation. J Biotechnol
125:304–310
Vanegas KG, Lehka BJ, Mortensen UH (2017) SWITCH:
a dynamic CRISPR tool for genome engineering
and metabolic pathway control for cell factory
construction in Saccharomyces cerevisiae. Microb
Cell Factories 16:1–12
Vesth TC, Nybo JL, Theobald S, Frisvad JC, Larsen TO,
Nielsen KF, Hoof JB, Brandl J, Salamov A, Riley R,
Gladden JM, Phatale P, Nielsen MT, Lyhne EK,
Kogle ME, Strasser K, McDonnell E, Barry K,
Clum A, Chen C, LaButti K, Haridas S, Nolan M,
Sandor L, Kuo A, Lipzen A, Hainaut M, Drula E,
Tsang A, Magnuson JK, Henrissat B, Wiebenga A,
Simmons BA, Ma ¨kela ¨ MR, de Vries RP, Grigoriev
IV, Mortensen UH, Baker SE, Andersen MR (2018)
Investigation of inter- and intraspecies variation
through genome sequencing of Aspergillus section
Nigri. Nat Genet 50:1688–1695
Vlaardingerbroek I, Beerens B, Shahi S, Rep M (2015)
Fluorescence assisted selection of Transformants
(FAST): using flow cytometry to select fungal
transformants. Fungal Genet Biol 76:104–109
Wang B, Guo G, Wang C, Lin Y, Wang X, Zhao M, Guo
Y, He M, Zhang Y, Pan L (2010) Survey of the
transcriptome of Aspergillus oryzae via massively
parallel mRNA sequencing. Nucleic Acids Res
38:5075–5087
Wanka F, Cairns T, Boecker S, Berens C, Happel A,
Zheng X, Sun J, Krappmann S, Meyer V (2016)
Tet-on, or Tet-off, that is the question: advanced
conditional gene expression in Aspergillus. Fungal
Genet Biol 89:72–83
Ward M, Wilson LJ, Carmona CL, Turner G (1988) The
oliC3 gene of Aspergillus niger: isolation, sequence
and use as a selectable marker for transformation.
Curr Genet 14:37–42
Waring RB, May GS, Morris NR (1989) Characterization of an inducible expression system in Aspergillus nidulans using alcA and tubulin coding genes.
Gene 79:119–130
Watanabe A, Ono Y, Fujii I, Sankawa U, Mayorga ME,
Timberlake WE, Ebizuka Y (1998) Product identification of polyketide synthase coded by Aspergillus nidulans wA gene. Tetrahedron Lett 39:7733–
7736
Watanabe A, Fujii I, Sankawa U, Mayorga ME, Timberlake WE, Ebizuka Y (1999) Re-identification of
Aspergillus nidulans wA gene to code for a polyketide synthase of naphthopyrone. Tetrahedron Lett
40:91–94
Wei W, Chen L, Zou G, Wang Q, Yan X, Zhang J, Wang
C, Zhou Z (2013) N-glycosylation affects the
proper folding, enzymatic characteristics and production of a fungal b-glucosidase. Biotechnol
Bioeng 110:3075–3084
Wernars K, Goosen T, Wennekes LMJ, Visser J, Bos CJ,
van den Broek HWJ, van Gorcom RFM, van den
Hondel CAMJJ, Pouwels PH (1985) Gene amplification in Aspergillus nidulans by transformation
with vectors containing the amdS gene. Curr Genet
9:361–368
Wiemann P, Soukup AA, Folz JS, Wang PM, Noack A,
Keller NP (2018) CoIN:co-inducible nitrate expression system for secondary metabolites in Aspergillus nidulans. Fungal Biol Biotechnol 5:1–10
Willis KJ (ed) (2018) State of the world’s fungi 2018.
Report. Royal Botanic Gardens, Kew
Wu Y, Sun X, Xue X, Luo H, Yao B, Xie X, Su X (2017)
Overexpressing key component genes of the secretion pathway for enhanced secretion of an Aspergillus niger glucose oxidase in Trichoderma reesei.
Enzym Microb Technol 106:83–87
Xie X, Meehan MJ, Xu W, Dorrestein PC, Tang Y (2009)
Acyltransferase mediated polyketide release from
a fungal megasynthase. J Am Chem Soc 131:8388–
8389
264
J. K. H. Rendsvig et al.