Bayram O ¨ , Braus GH, Fischer R, Rodriguez-Romero J
(2010) Spotlight on Aspergillus nidulans photosensory systems. Fungal Genet Biol 47:900–908
Bayram O ¨ , Feussner K, Dumkow M, Herrfurth C, Feussner I, Braus GH (2016) Changes of global gene
expression and secondary metabolite accumulation during light-dependent Aspergillus nidulans
development. Fungal Genet Biol 87:30–53
Becker K, Ziemons S, Lentz K, Freitag M, Ku ¨ck U (2016)
Genome-wide chromatin immunoprecipitation
sequencing analysis of the Penicillium chrysogenum velvet protein PcVelA identifies methyltransferase PcLlmA as a novel downstream
regulator of fungal development. mSphere 1:
e00149–e00116
Beckmann EA, Ko ¨hler AM, Meister C, Christmann M,
Draht OW, Rakebrandt N, Valerius O, Braus GH
(2015) Integration of the catalytic subunit activates
deneddylase activity in vivo as final step in fungal
COP9 signalosome assembly. Mol Microbiol
97:110–124
Bicocca VT, Ormsby T, Adhvaryu KK, Honda S, Selker
EU (2018) ASH1-catalyzed H3K36 methylation
drives gene repression and marks H3K27me2/3competent chromatin. Elife 7:e41497
Blumenstein A, Vienken K, Tasler R, Purschwitz J,
Veith D, Frankenberg-Dinkel N, Fischer R (2005)
The Aspergillus nidulans phytochrome FphA
represses sexual development in red light. Curr
Biol 15:1833–1838
Bode HB, Bethe B, Ho ¨fs R, Zeeck A (2002) Big effects
from small changes: possible ways to explore nature’s chemical diversity. ChemBioChem 3:619–627
Bok JW, Keller NP (2016) Insight into fungal secondary
metabolism from ten years of LaeA research. In:
Hoffmeister D (ed) Biochemistry and molecular
biology: the Mycota (A comprehensive treatise on
fungi as experimental systems for basic and
applied research), vol III. Springer International
Publishing, Cham, pp 21–29
Braus GH, Irniger S, Bayram O ¨ (2010) Fungal development and the COP9 signalosome. Curr Opin
Microbiol 13:672–676
Brodhun F, Feussner I (2011) Oxylipins in fungi. FEBS J
278:1047–1063
Brosch G, Loidl P, Graessle S (2008) Histone modifications and chromatin dynamics: a focus on filamentous fungi. FEMS Microbiol Rev 32:409–439
Brown NA, Schrevens S, van Dijck P, Goldman GH
(2018) Fungal G-protein-coupled receptors: mediators of pathogenesis and targets for disease control. Nat Microbiol 3:402–414
Budenholzer L, Cheng CL, Li Y, Hochstrasser M (2017)
Proteasome structure and assembly. J Mol Biol
429:3500–3524
Budovskaya Y, Stephan J, Reggiori F, Klionsky DJ, Herman PK (2004) The Ras/PKA signaling pathway
regulates an early step of the autophagy process in
Saccharomyces cerevisiae. J Biol Chem 279:20663
Busch S, Eckert SE, Krappmann S, Braus GH (2003) The
COP9 signalosome is an essential regulator of
development in the filamentous fungus Aspergillus
nidulans. Mol Microbiol 49:717–730
Busch S, Schwier EU, Nahlik K, Bayram O ¨ , Helmstaedt
K, Draht OW, Krappmann S, Valerius O, Lipscomb
WN, Braus GH (2007) An eight-subunit COP9
signalosome with an intact JAMM motif is
required for fungal fruit body formation. Proc
Natl Acad Sci USA 104:8089–8094
Cassini A, Diaz Ho ¨gberg L, Plachouras D, Quattrocchi
A, Hoxha A, Skov Simonsen G (2019) Attributable
deaths and disability-adjusted life-years caused by
infections with antibiotic-resistant bacteria in the
EU and the European Economic Area in 2015: a
population-level modelling analysis. Lancet Infect
Dis 19:56–66
Castrillo M, Garcı ´a-Martı ´nez J, Avalos J (2013) Lightdependent functions of the Fusarium fujikuroi
CryD DASH cryptochrome in development and
secondary metabolism. Appl Environ Microbiol
79:2777–2788
Cetz-Chel JE, Balcázar-Lo ´pez E, Esquivel-Naranjo EU,
Herrera-Estrella A (2016) The Trichoderma atroviride putative transcription factor Blu7 controls
light responsiveness and tolerance. BMC Genomics 17:327
Chanda A, Roze L, Kang S, Artymovich KA, Hicks GR,
Raikhel N, Calvo AM, Linz JE (2009) A key role for
vesicles in fungal secondary metabolism. Proc Natl
Acad Sci USA 106:19533–19538
Chiang YM, Oakley CE, Ahuja M, Entwistle R, Schultz
A, Chang S-L, Sung CT, Wang CCC, Oakley BR
(2013) An efficient system for heterologous
expression of secondary metabolite genes in
Aspergillus nidulans. J Am Chem Soc 135:7720–
7731
Chinnici JL, Fu C, Caccamise LM, Arnold JW, Free SJ
(2014) Neurospora crassa female development
requires the PACC and other signal transduction
pathways, transcription factors, chromatin remodeling, cell-to-cell fusion, and autophagy. PLoS
One 9:e110603
Choo YY, Boh BK, Lou JJW, Eng J, Leck YC, Anders B,
Smith PG, Hagen T (2011) Characterization of the
role of COP9 signalosome in regulating cullin E3
ubiquitin ligase activity. Mol Biol Cell 22:4706–
4715
Christmann M, Schmaler T, Gordon C, Huang X,
Bayram O ¨ , Schinke J, Stumpf S, Dubiel W, Braus
GH (2013) Control of multicellular development
by the physically interacting deneddylases DEN1/
DenA and COP9 signalosome. PLoS Genet 9:
e1003275
Chu X-L, Feng M-G, Ying S-H (2016) Qualitative ubiquitome unveils the potential significances of protein lysine ubiquitination in hyphal growth of
Aspergillus nidulans. Curr Genet 62:191–201
Connolly LR, Smith KM, Freitag M (2013) The Fusarium graminearum histone H3 K27 methyltransferase KMT6 regulates development and expression
of secondary metabolite gene clusters. PLoS Genet
9:e1003916
8 Coordination of Fungal Secondary Metabolism and Development
197
(2010) Spotlight on Aspergillus nidulans photosensory systems. Fungal Genet Biol 47:900–908
Bayram O ¨ , Feussner K, Dumkow M, Herrfurth C, Feussner I, Braus GH (2016) Changes of global gene
expression and secondary metabolite accumulation during light-dependent Aspergillus nidulans
development. Fungal Genet Biol 87:30–53
Becker K, Ziemons S, Lentz K, Freitag M, Ku ¨ck U (2016)
Genome-wide chromatin immunoprecipitation
sequencing analysis of the Penicillium chrysogenum velvet protein PcVelA identifies methyltransferase PcLlmA as a novel downstream
regulator of fungal development. mSphere 1:
e00149–e00116
Beckmann EA, Ko ¨hler AM, Meister C, Christmann M,
Draht OW, Rakebrandt N, Valerius O, Braus GH
(2015) Integration of the catalytic subunit activates
deneddylase activity in vivo as final step in fungal
COP9 signalosome assembly. Mol Microbiol
97:110–124
Bicocca VT, Ormsby T, Adhvaryu KK, Honda S, Selker
EU (2018) ASH1-catalyzed H3K36 methylation
drives gene repression and marks H3K27me2/3competent chromatin. Elife 7:e41497
Blumenstein A, Vienken K, Tasler R, Purschwitz J,
Veith D, Frankenberg-Dinkel N, Fischer R (2005)
The Aspergillus nidulans phytochrome FphA
represses sexual development in red light. Curr
Biol 15:1833–1838
Bode HB, Bethe B, Ho ¨fs R, Zeeck A (2002) Big effects
from small changes: possible ways to explore nature’s chemical diversity. ChemBioChem 3:619–627
Bok JW, Keller NP (2016) Insight into fungal secondary
metabolism from ten years of LaeA research. In:
Hoffmeister D (ed) Biochemistry and molecular
biology: the Mycota (A comprehensive treatise on
fungi as experimental systems for basic and
applied research), vol III. Springer International
Publishing, Cham, pp 21–29
Braus GH, Irniger S, Bayram O ¨ (2010) Fungal development and the COP9 signalosome. Curr Opin
Microbiol 13:672–676
Brodhun F, Feussner I (2011) Oxylipins in fungi. FEBS J
278:1047–1063
Brosch G, Loidl P, Graessle S (2008) Histone modifications and chromatin dynamics: a focus on filamentous fungi. FEMS Microbiol Rev 32:409–439
Brown NA, Schrevens S, van Dijck P, Goldman GH
(2018) Fungal G-protein-coupled receptors: mediators of pathogenesis and targets for disease control. Nat Microbiol 3:402–414
Budenholzer L, Cheng CL, Li Y, Hochstrasser M (2017)
Proteasome structure and assembly. J Mol Biol
429:3500–3524
Budovskaya Y, Stephan J, Reggiori F, Klionsky DJ, Herman PK (2004) The Ras/PKA signaling pathway
regulates an early step of the autophagy process in
Saccharomyces cerevisiae. J Biol Chem 279:20663
Busch S, Eckert SE, Krappmann S, Braus GH (2003) The
COP9 signalosome is an essential regulator of
development in the filamentous fungus Aspergillus
nidulans. Mol Microbiol 49:717–730
Busch S, Schwier EU, Nahlik K, Bayram O ¨ , Helmstaedt
K, Draht OW, Krappmann S, Valerius O, Lipscomb
WN, Braus GH (2007) An eight-subunit COP9
signalosome with an intact JAMM motif is
required for fungal fruit body formation. Proc
Natl Acad Sci USA 104:8089–8094
Cassini A, Diaz Ho ¨gberg L, Plachouras D, Quattrocchi
A, Hoxha A, Skov Simonsen G (2019) Attributable
deaths and disability-adjusted life-years caused by
infections with antibiotic-resistant bacteria in the
EU and the European Economic Area in 2015: a
population-level modelling analysis. Lancet Infect
Dis 19:56–66
Castrillo M, Garcı ´a-Martı ´nez J, Avalos J (2013) Lightdependent functions of the Fusarium fujikuroi
CryD DASH cryptochrome in development and
secondary metabolism. Appl Environ Microbiol
79:2777–2788
Cetz-Chel JE, Balcázar-Lo ´pez E, Esquivel-Naranjo EU,
Herrera-Estrella A (2016) The Trichoderma atroviride putative transcription factor Blu7 controls
light responsiveness and tolerance. BMC Genomics 17:327
Chanda A, Roze L, Kang S, Artymovich KA, Hicks GR,
Raikhel N, Calvo AM, Linz JE (2009) A key role for
vesicles in fungal secondary metabolism. Proc Natl
Acad Sci USA 106:19533–19538
Chiang YM, Oakley CE, Ahuja M, Entwistle R, Schultz
A, Chang S-L, Sung CT, Wang CCC, Oakley BR
(2013) An efficient system for heterologous
expression of secondary metabolite genes in
Aspergillus nidulans. J Am Chem Soc 135:7720–
7731
Chinnici JL, Fu C, Caccamise LM, Arnold JW, Free SJ
(2014) Neurospora crassa female development
requires the PACC and other signal transduction
pathways, transcription factors, chromatin remodeling, cell-to-cell fusion, and autophagy. PLoS
One 9:e110603
Choo YY, Boh BK, Lou JJW, Eng J, Leck YC, Anders B,
Smith PG, Hagen T (2011) Characterization of the
role of COP9 signalosome in regulating cullin E3
ubiquitin ligase activity. Mol Biol Cell 22:4706–
4715
Christmann M, Schmaler T, Gordon C, Huang X,
Bayram O ¨ , Schinke J, Stumpf S, Dubiel W, Braus
GH (2013) Control of multicellular development
by the physically interacting deneddylases DEN1/
DenA and COP9 signalosome. PLoS Genet 9:
e1003275
Chu X-L, Feng M-G, Ying S-H (2016) Qualitative ubiquitome unveils the potential significances of protein lysine ubiquitination in hyphal growth of
Aspergillus nidulans. Curr Genet 62:191–201
Connolly LR, Smith KM, Freitag M (2013) The Fusarium graminearum histone H3 K27 methyltransferase KMT6 regulates development and expression
of secondary metabolite gene clusters. PLoS Genet
9:e1003916
8 Coordination of Fungal Secondary Metabolism and Development
197