CSP1 on the core oscillator. Genes Dev 26:2435–
2442. https://doi.org/10.1101/gad.199547.112
Sancar C, Sancar G, Ha N et al (2015) Dawn- and duskphased circadian transcription rhythms coordinate anabolic and catabolic functions in Neurospora. BMC Biol 13:17–19. https://doi.org/10.1186/
s12915-015-0126-4
Schafmeier T, Haase A, Ka ´ldi K et al (2005) Transcriptional feedback of Neurospora circadian clock gene
by phosphorylation-dependent inactivation of its
transcription factor. Cell 122:235–246. https://doi.
org/10.1016/j.cell.2005.05.032
Schafmeier T, Ka ´ldi K, Diernfellner A et al (2006)
Phosphorylation-dependent maturation of Neurospora circadian clock protein from a nuclear
repressor toward a cytoplasmic activator. Genes
Dev
20:297–306.
https://doi.org/10.1101/
gad.360906
Schafmeier T, Diernfellner A, Scha ¨fer A et al (2008)
Circadian activity and abundance rhythms of the
Neurospora clock transcription factor WCC associated with rapid nucleo-cytoplasmic shuttling.
Genes Dev 22:3397–3402. https://doi.org/10.1101/
gad.507408
Schumacher J, Tudzynski P (2012) In: Pe ´rez-Martı ´n J,
Di Pietro A (eds) Morphogenesis and infection in
Botrytis cinerea BT – morphogenesis and pathogenicity in Fungi. Springer, Berlin, pp 225–241
Shi M, Collett M, Loros JJ, Dunlap JC (2010) FRQinteracting RNA helicase mediates negative and
positive feedback in the Neurospora circadian
clock. Genetics 184:351–361. https://doi.org/
10.1534/genetics.109.111393
Smith KM, Sancar G, Dekhang R et al (2010) Transcription factors in light and circadian clock signaling
networks revealed by genomewide mapping of
direct targets for Neurospora white collar complex.
Eukaryot Cell 9:1549–1556. https://doi.org/
10.1128/EC.00154-10
Starkey N, McDonald J, Lee K (2013) PERIOD-1 is a
component of the Neurospora metabolic oscillator.
Lett Gen Microbiol 1:13–15
Sun G, Zhou Z, Liu X et al (2016) Suppression of
WHITE COLLAR-independent frequency transcription by histone H3 lysine 36 methyltransferase SET-2 is necessary for clock function in
Neurospora. J Biol Chem 291:11055–11063.
https://doi.org/10.1074/jbc.M115.711333
Takahashi JS (2017) Transcriptional architecture of the
mammalian circadian clock. Nat Rev Genet
18:164–179. https://doi.org/10.1038/nrg.2016.150
Tan Y, Merrow M, Roenneberg T (2004) Photoperiodism in Neurospora crassa. J Biol Rhythm 19:135–
143. https://doi.org/10.1177/0748730404263015
Tang C-T, Li S, Long C et al (2009) Setting the pace of
the Neurospora circadian clock by multiple independent FRQ phosphorylation events. Proc Natl
Acad Sci U S A 106:10722–10727. https://doi.org/
10.1073/pnas.0904898106
Tatarog ˘lu O ¨ , Lauinger L, Sancar G et al (2012) Glycogen
synthase kinase is a regulator of the circadian
clock of Neurospora crassa. J Biol Chem
287:36936–36943.
https://doi.org/10.1074/jbc.
M112.396622
Traeger S, Nowrousian M (2015) Analysis of circadian
rhythms in the basal filamentous ascomycete
Pyronema confluens. G3 Genes|Genomes|Genetics
5:2061–2071. https://doi.org/10.1534/g3.115.020461
Tsvetkov P, Reuven N, Shaul Y (2009) The nanny model
for IDPs. Nat Chem Biol 5:778
Vitalini MW, de Paula RM, Park WD, Bell-Pedersen D
(2006) The rhythms of life: circadian output pathways in Neurospora. J Biol Rhythm 21:432–444.
https://doi.org/10.1177/0748730406294396
Wang B, Kettenbach AN, Gerber SA et al (2014) Neurospora WC-1 recruits SWI/SNF to remodel frequency and initiate a circadian cycle. PLoS Genet
10:e1004599
Wang B, Zhou XY, Loros JJ, Dunlap JC (2016) Alternative use of DNA binding domains by the Neurospora white collar complex dictates circadian
regulation and light responses. Mol Cell Biol
36:781–793. https://doi.org/10.1128/MCB.00841-15
Wang B, Kettenbach AN, Zhou X et al (2019) The
Phospho-code determining circadian feedback
loop closure and output in Neurospora. Mol Cell
74:771–784.e3.
https://doi.org/10.1016/j.molcel.2019.03.003
Weber F, Zorn D, Rademacher C, Hung H-C (2011)
Post-translational timing mechanisms of the Drosophila circadian clock. FEBS Lett 585:1443–1449.
https://doi.org/10.1016/j.febslet.2011.04.008
Wu C, Yang F, Smith KM et al (2014) Genome-wide
characterization of light-regulated genes in Neurospora crassa. G3 Genes|Genomes|Genetics 4:1731–
1745. https://doi.org/10.1534/g3.114.012617
Xu Y, Ma P, Shah P et al (2013) Non-optimal codon
usage is a mechanism to achieve circadian clock
conditionality. Nature 495:116–120. https://doi.
org/10.1038/nature11942
Xue Z, Ye Q, Anson SR et al (2014) Transcriptional
interference by antisense RNA is required for circadian clock function. Nature 514:650–653.
https://doi.org/10.1038/nature13671
Yang Y, Cheng P, Zhi G, Liu Y (2001) Identification of a
calcium/calmodulin-dependent protein kinase
that phosphorylates the Neurospora circadian
clock protein FREQUENCY. J Biol Chem
276:41064–41072.
https://doi.org/10.1074/jbc.
M106905200
Yang Y, Cheng P, Liu Y (2002) Regulation of the Neurospora circadian clock by casein kinase II. Genes Dev
16:994–1006. https://doi.org/10.1101/gad.965102
Yang Y, He Q, Cheng P (2004) Distinct roles for PP1
and PP2A in the Neurospora circadian clock.
Genes Dev 18:255–260. https://doi.org/10.1101/
gad.1152604
102
M. S. Jankowski et al.
2442. https://doi.org/10.1101/gad.199547.112
Sancar C, Sancar G, Ha N et al (2015) Dawn- and duskphased circadian transcription rhythms coordinate anabolic and catabolic functions in Neurospora. BMC Biol 13:17–19. https://doi.org/10.1186/
s12915-015-0126-4
Schafmeier T, Haase A, Ka ´ldi K et al (2005) Transcriptional feedback of Neurospora circadian clock gene
by phosphorylation-dependent inactivation of its
transcription factor. Cell 122:235–246. https://doi.
org/10.1016/j.cell.2005.05.032
Schafmeier T, Ka ´ldi K, Diernfellner A et al (2006)
Phosphorylation-dependent maturation of Neurospora circadian clock protein from a nuclear
repressor toward a cytoplasmic activator. Genes
Dev
20:297–306.
https://doi.org/10.1101/
gad.360906
Schafmeier T, Diernfellner A, Scha ¨fer A et al (2008)
Circadian activity and abundance rhythms of the
Neurospora clock transcription factor WCC associated with rapid nucleo-cytoplasmic shuttling.
Genes Dev 22:3397–3402. https://doi.org/10.1101/
gad.507408
Schumacher J, Tudzynski P (2012) In: Pe ´rez-Martı ´n J,
Di Pietro A (eds) Morphogenesis and infection in
Botrytis cinerea BT – morphogenesis and pathogenicity in Fungi. Springer, Berlin, pp 225–241
Shi M, Collett M, Loros JJ, Dunlap JC (2010) FRQinteracting RNA helicase mediates negative and
positive feedback in the Neurospora circadian
clock. Genetics 184:351–361. https://doi.org/
10.1534/genetics.109.111393
Smith KM, Sancar G, Dekhang R et al (2010) Transcription factors in light and circadian clock signaling
networks revealed by genomewide mapping of
direct targets for Neurospora white collar complex.
Eukaryot Cell 9:1549–1556. https://doi.org/
10.1128/EC.00154-10
Starkey N, McDonald J, Lee K (2013) PERIOD-1 is a
component of the Neurospora metabolic oscillator.
Lett Gen Microbiol 1:13–15
Sun G, Zhou Z, Liu X et al (2016) Suppression of
WHITE COLLAR-independent frequency transcription by histone H3 lysine 36 methyltransferase SET-2 is necessary for clock function in
Neurospora. J Biol Chem 291:11055–11063.
https://doi.org/10.1074/jbc.M115.711333
Takahashi JS (2017) Transcriptional architecture of the
mammalian circadian clock. Nat Rev Genet
18:164–179. https://doi.org/10.1038/nrg.2016.150
Tan Y, Merrow M, Roenneberg T (2004) Photoperiodism in Neurospora crassa. J Biol Rhythm 19:135–
143. https://doi.org/10.1177/0748730404263015
Tang C-T, Li S, Long C et al (2009) Setting the pace of
the Neurospora circadian clock by multiple independent FRQ phosphorylation events. Proc Natl
Acad Sci U S A 106:10722–10727. https://doi.org/
10.1073/pnas.0904898106
Tatarog ˘lu O ¨ , Lauinger L, Sancar G et al (2012) Glycogen
synthase kinase is a regulator of the circadian
clock of Neurospora crassa. J Biol Chem
287:36936–36943.
https://doi.org/10.1074/jbc.
M112.396622
Traeger S, Nowrousian M (2015) Analysis of circadian
rhythms in the basal filamentous ascomycete
Pyronema confluens. G3 Genes|Genomes|Genetics
5:2061–2071. https://doi.org/10.1534/g3.115.020461
Tsvetkov P, Reuven N, Shaul Y (2009) The nanny model
for IDPs. Nat Chem Biol 5:778
Vitalini MW, de Paula RM, Park WD, Bell-Pedersen D
(2006) The rhythms of life: circadian output pathways in Neurospora. J Biol Rhythm 21:432–444.
https://doi.org/10.1177/0748730406294396
Wang B, Kettenbach AN, Gerber SA et al (2014) Neurospora WC-1 recruits SWI/SNF to remodel frequency and initiate a circadian cycle. PLoS Genet
10:e1004599
Wang B, Zhou XY, Loros JJ, Dunlap JC (2016) Alternative use of DNA binding domains by the Neurospora white collar complex dictates circadian
regulation and light responses. Mol Cell Biol
36:781–793. https://doi.org/10.1128/MCB.00841-15
Wang B, Kettenbach AN, Zhou X et al (2019) The
Phospho-code determining circadian feedback
loop closure and output in Neurospora. Mol Cell
74:771–784.e3.
https://doi.org/10.1016/j.molcel.2019.03.003
Weber F, Zorn D, Rademacher C, Hung H-C (2011)
Post-translational timing mechanisms of the Drosophila circadian clock. FEBS Lett 585:1443–1449.
https://doi.org/10.1016/j.febslet.2011.04.008
Wu C, Yang F, Smith KM et al (2014) Genome-wide
characterization of light-regulated genes in Neurospora crassa. G3 Genes|Genomes|Genetics 4:1731–
1745. https://doi.org/10.1534/g3.114.012617
Xu Y, Ma P, Shah P et al (2013) Non-optimal codon
usage is a mechanism to achieve circadian clock
conditionality. Nature 495:116–120. https://doi.
org/10.1038/nature11942
Xue Z, Ye Q, Anson SR et al (2014) Transcriptional
interference by antisense RNA is required for circadian clock function. Nature 514:650–653.
https://doi.org/10.1038/nature13671
Yang Y, Cheng P, Zhi G, Liu Y (2001) Identification of a
calcium/calmodulin-dependent protein kinase
that phosphorylates the Neurospora circadian
clock protein FREQUENCY. J Biol Chem
276:41064–41072.
https://doi.org/10.1074/jbc.
M106905200
Yang Y, Cheng P, Liu Y (2002) Regulation of the Neurospora circadian clock by casein kinase II. Genes Dev
16:994–1006. https://doi.org/10.1101/gad.965102
Yang Y, He Q, Cheng P (2004) Distinct roles for PP1
and PP2A in the Neurospora circadian clock.
Genes Dev 18:255–260. https://doi.org/10.1101/
gad.1152604
102
M. S. Jankowski et al.