Lamb TM, Goldsmith CS, Bennett L et al (2011) Direct
transcriptional control of a p38 MAPK pathway by
the circadian clock in Neurospora crassa. PLoS
One 6:e27149–e27149. https://doi.org/10.1371/
journal.pone.0027149
Lamb TM, Finch KE, Bell-Pedersen D (2012) The Neurospora crassa OS MAPK pathway-activated transcription factor ASL-1 contributes to circadian
rhythms in pathway responsive clock-controlled
genes. Fungal Genet Biol 49:180–188. https://doi.
org/10.1016/j.fgb.2011.12.006
Lambreghts R, Shi M, Belden WJ et al (2009) A highdensity single nucleotide polymorphism map for
Neurospora crassa. Genetics 181:767–781. https://
doi.org/10.1534/genetics.108.089292
Larrondo LF, Loros JJ, Dunlap JC (2012) Highresolution spatiotemporal analysis of gene expression in real time: in vivo analysis of circadian
rhythms in Neurospora crassa using a
FREQUENCY-luciferase translational reporter.
Fungal Genet Biol 49:681–683. https://doi.org/
10.1016/j.fgb.2012.06.001
Larrondo LF, Olivares-Yan ˜ez C, Baker CL et al (2015)
Decoupling circadian clock protein turnover from
circadian
period
determination.
Science
347:1257277.
https://doi.org/10.1126/science.1257277
Lee K, Loros JJ, Dunlap JC (2000) Interconnected feedback loops in the Neurospora circadian system.
Science 289(80):107–110. https://doi.org/10.1126/
science.289.5476.107
Lee H, Chen R, Lee Y et al (2009) Essential roles of CKId
and CKIe in the mammalian circadian clock. Proc
Natl Acad Sci 106:21359. https://doi.org/10.1073/
pnas.0906651106
Lee E, Jeong EH, Jeong H-J et al (2014) Phosphorylation
of a central clock transcription factor is required
for thermal but not photic entrainment. PLoS
Genet 10:e1004545–e1004545. https://doi.org/
10.1371/journal.pgen.1004545
Li N, Joska TM, Ruesch CE, Coster SJ, Belden WJ (2015)
The natural antisense transcript first promotes,
then represses, gene expression via facultative heterochromatin. Proc Natl Acad Sci USA 112
(14):4357–4362.
https://doi.org/10.1073/
pnas.1406130112
Linden H, Macino G (1997) White collar 2, a partner in
blue-light signal transduction, controlling expression of light–regulated genes in Neurospora crassa.
EMBO J 16:98–109. https://doi.org/10.1093/emboj/
16.1.98
Linden H, Ballario P, Macino G (1997) Blue light regulation in Neurospora crassa. Fungal Genet Biol
22:141–150. https://doi.org/10.1006/fgbi.1997.1013
Liu Y, Garceau NY, Loros JJ, Dunlap JC (1997) Thermally regulated translational control of FRQ mediates aspects of temperature responses in the
Neurospora circadian clock. Cell 89:477–486.
https://doi.org/10.1016/S0092-8674(00)80228-7
Liu Y, Merrow M, Loros JJ, Dunlap JC (1998) How
temperature changes reset a circadian oscillator.
Science 281(80):825
Liu Y, Loros J, Dunlap JC (2000) Phosphorylation of the
Neurospora clock protein FREQUENCY determines its degradation rate and strongly influences
the period length of the circadian clock. Proc Natl
Acad Sci U S A 97:234–239
Loros JJ (2019) Principles of the animal molecular clock
learned from Neurospora. Eur J Neurosci 51:19.
https://doi.org/10.1111/ejn.14354
Loros JJ, Richman A, Feldman J (1986) A recessive
circadian clock mutation at the frq locus of Neurospora crassa. Genetics 114(4):1095–1110
Loros JJ, Denome SA, Dunlap JC (1989) Molecular
cloning of genes under control of the circadian
clock in Neurospora. Science 243(80):385–388.
https://doi.org/10.1126/science.2563175
Lu ¨ck S, Thurley K, Thaben PF, Westermark PO (2014)
Rhythmic degradation explains and unifies circadian transcriptome and proteome data. Cell Rep
9:741–751.
https://doi.org/10.1016/j.celrep.2014.09.021
Luo C, Loros JJ, Dunlap JC (1998) Nuclear localization
is required for function of the essential clock protein FRQ. Embo 17:1228–1235
Lykke-Andersen S, Tomecki R, Jensen TH, Dziembowski A (2011) The eukaryotic RNA exosome: same
scaffold but variable catalytic subunits. RNA Biol
8:61–66
Lysek G, Esser K (1970) Rhythmic mycelial growth in
Podospora anserina. Arch Mikrobiol 73:224–230.
https://doi.org/10.1007/BF00410623
Mahesh G, Jeong E, Ng FS et al (2014) Phosphorylation
of the transcription activator CLOCK regulates
progression through a $ 24-h feedback loop to
influence the circadian period in Drosophila. J
Biol Chem 289:19681–19693. https://doi.org/
10.1074/jbc.M114.568493
Malzahn E, Ciprianidis S, Ka ´ldi K et al (2010) Photoadaptation in Neurospora by competitive interaction of activating and inhibitory LOV domains.
Cell
142:762–772.
https://doi.org/10.1016/j.
cell.2010.08.010
McCluskey K, Wiest A, Plamann M (2010) The fungal
genetics stock center: a repository for 50 years of
fungal genetics research. J Biosci 35:119
Mehra A, Baker C, Loros J, Dunlap J (2009a) Posttranslational modification in circadian rhythms.
Trends Biochem Sci 34:483–490. https://doi.org/
10.1016/j.tibs.2009.06.006.Post-Translational
Mehra A, Shi M, Baker CL et al (2009b) A role for casein
kinase 2 in the mechanism underlying circadian
temperature compensation. Cell 137:749–760.
https://doi.org/10.1016/j.cell.2009.03.019
Menet JS, Pescatore S, Rosbash M (2014) CLOCK:
BMAL1 is a pioneer-like transcription factor.
Genes Dev 28:8–13. https://doi.org/10.1101/
gad.228536.113
Merrow MW, Dunlap JC (1994) Intergeneric complementation of a circadian rhythmicity defect: phy100
M. S. Jankowski et al.
transcriptional control of a p38 MAPK pathway by
the circadian clock in Neurospora crassa. PLoS
One 6:e27149–e27149. https://doi.org/10.1371/
journal.pone.0027149
Lamb TM, Finch KE, Bell-Pedersen D (2012) The Neurospora crassa OS MAPK pathway-activated transcription factor ASL-1 contributes to circadian
rhythms in pathway responsive clock-controlled
genes. Fungal Genet Biol 49:180–188. https://doi.
org/10.1016/j.fgb.2011.12.006
Lambreghts R, Shi M, Belden WJ et al (2009) A highdensity single nucleotide polymorphism map for
Neurospora crassa. Genetics 181:767–781. https://
doi.org/10.1534/genetics.108.089292
Larrondo LF, Loros JJ, Dunlap JC (2012) Highresolution spatiotemporal analysis of gene expression in real time: in vivo analysis of circadian
rhythms in Neurospora crassa using a
FREQUENCY-luciferase translational reporter.
Fungal Genet Biol 49:681–683. https://doi.org/
10.1016/j.fgb.2012.06.001
Larrondo LF, Olivares-Yan ˜ez C, Baker CL et al (2015)
Decoupling circadian clock protein turnover from
circadian
period
determination.
Science
347:1257277.
https://doi.org/10.1126/science.1257277
Lee K, Loros JJ, Dunlap JC (2000) Interconnected feedback loops in the Neurospora circadian system.
Science 289(80):107–110. https://doi.org/10.1126/
science.289.5476.107
Lee H, Chen R, Lee Y et al (2009) Essential roles of CKId
and CKIe in the mammalian circadian clock. Proc
Natl Acad Sci 106:21359. https://doi.org/10.1073/
pnas.0906651106
Lee E, Jeong EH, Jeong H-J et al (2014) Phosphorylation
of a central clock transcription factor is required
for thermal but not photic entrainment. PLoS
Genet 10:e1004545–e1004545. https://doi.org/
10.1371/journal.pgen.1004545
Li N, Joska TM, Ruesch CE, Coster SJ, Belden WJ (2015)
The natural antisense transcript first promotes,
then represses, gene expression via facultative heterochromatin. Proc Natl Acad Sci USA 112
(14):4357–4362.
https://doi.org/10.1073/
pnas.1406130112
Linden H, Macino G (1997) White collar 2, a partner in
blue-light signal transduction, controlling expression of light–regulated genes in Neurospora crassa.
EMBO J 16:98–109. https://doi.org/10.1093/emboj/
16.1.98
Linden H, Ballario P, Macino G (1997) Blue light regulation in Neurospora crassa. Fungal Genet Biol
22:141–150. https://doi.org/10.1006/fgbi.1997.1013
Liu Y, Garceau NY, Loros JJ, Dunlap JC (1997) Thermally regulated translational control of FRQ mediates aspects of temperature responses in the
Neurospora circadian clock. Cell 89:477–486.
https://doi.org/10.1016/S0092-8674(00)80228-7
Liu Y, Merrow M, Loros JJ, Dunlap JC (1998) How
temperature changes reset a circadian oscillator.
Science 281(80):825
Liu Y, Loros J, Dunlap JC (2000) Phosphorylation of the
Neurospora clock protein FREQUENCY determines its degradation rate and strongly influences
the period length of the circadian clock. Proc Natl
Acad Sci U S A 97:234–239
Loros JJ (2019) Principles of the animal molecular clock
learned from Neurospora. Eur J Neurosci 51:19.
https://doi.org/10.1111/ejn.14354
Loros JJ, Richman A, Feldman J (1986) A recessive
circadian clock mutation at the frq locus of Neurospora crassa. Genetics 114(4):1095–1110
Loros JJ, Denome SA, Dunlap JC (1989) Molecular
cloning of genes under control of the circadian
clock in Neurospora. Science 243(80):385–388.
https://doi.org/10.1126/science.2563175
Lu ¨ck S, Thurley K, Thaben PF, Westermark PO (2014)
Rhythmic degradation explains and unifies circadian transcriptome and proteome data. Cell Rep
9:741–751.
https://doi.org/10.1016/j.celrep.2014.09.021
Luo C, Loros JJ, Dunlap JC (1998) Nuclear localization
is required for function of the essential clock protein FRQ. Embo 17:1228–1235
Lykke-Andersen S, Tomecki R, Jensen TH, Dziembowski A (2011) The eukaryotic RNA exosome: same
scaffold but variable catalytic subunits. RNA Biol
8:61–66
Lysek G, Esser K (1970) Rhythmic mycelial growth in
Podospora anserina. Arch Mikrobiol 73:224–230.
https://doi.org/10.1007/BF00410623
Mahesh G, Jeong E, Ng FS et al (2014) Phosphorylation
of the transcription activator CLOCK regulates
progression through a $ 24-h feedback loop to
influence the circadian period in Drosophila. J
Biol Chem 289:19681–19693. https://doi.org/
10.1074/jbc.M114.568493
Malzahn E, Ciprianidis S, Ka ´ldi K et al (2010) Photoadaptation in Neurospora by competitive interaction of activating and inhibitory LOV domains.
Cell
142:762–772.
https://doi.org/10.1016/j.
cell.2010.08.010
McCluskey K, Wiest A, Plamann M (2010) The fungal
genetics stock center: a repository for 50 years of
fungal genetics research. J Biosci 35:119
Mehra A, Baker C, Loros J, Dunlap J (2009a) Posttranslational modification in circadian rhythms.
Trends Biochem Sci 34:483–490. https://doi.org/
10.1016/j.tibs.2009.06.006.Post-Translational
Mehra A, Shi M, Baker CL et al (2009b) A role for casein
kinase 2 in the mechanism underlying circadian
temperature compensation. Cell 137:749–760.
https://doi.org/10.1016/j.cell.2009.03.019
Menet JS, Pescatore S, Rosbash M (2014) CLOCK:
BMAL1 is a pioneer-like transcription factor.
Genes Dev 28:8–13. https://doi.org/10.1101/
gad.228536.113
Merrow MW, Dunlap JC (1994) Intergeneric complementation of a circadian rhythmicity defect: phy100
M. S. Jankowski et al.