Dunlap JC, Borkovich KA, Henn MR et al (2007)
Enabling a community to dissect an organism:
overview of the Neurospora functional genomics
project. Adv Genet 57:49–96. https://doi.org/
10.1016/S0065-2660(06)57002-6
Eide EJ, Woolf MF, Kang H et al (2005) Control of
mammalian circadian rhythm by CKI-regulated
proteasome-mediated PER2 degradation. Mol
Cell Biol 25:2795–2807. https://doi.org/10.1128/
MCB.25.7.2795-2807.2005
Emerson JM, Bartholomai BM, Ringelberg CS et al
(2015) Period-1 encodes an ATP-dependent RNA
helicase that influences nutritional compensation
of the Neurospora circadian clock. Proc Natl Acad
Sci U S A 112:15707–15712. https://doi.org/
10.1073/pnas.1521918112
Feeney KA, Hansen LL, Putker M et al (2016) Daily
magnesium fluxes regulate cellular timekeeping
and energy balance. Nature 532:375
Feldman JF, Hoyle MN (1973) Isolation of circadian
clock mutants of Neurospora crassa. Genetics
75:605–613
Filippovich SY, Bachurina GP, Shcherbakov DL (2015)
Quantitative assessment of the combined effect of
the nitrogen status, light and dehydration of mycelium on conidiation in Neurospora crassa. Appl
Biochem Microbiol 51:342–349. https://doi.org/
10.1134/S0003683815030060
Froehlich AC, Liu Y, Loros JJ, Dunlap JC (2002) White
Collar-1, a circadian blue light photoreceptor,
binding to the frequency promoter. Science 297
(80):815–819
Froehlich AC, Loros JJ, Dunlap JC (2003) Rhythmic
binding of a WHITE COLLAR-containing complex
to the frequency promoter is inhibited by FREQUENCY. Proc Natl Acad Sci U S A 100:5914–
5919. https://doi.org/10.1073/pnas.1030057100
Fu J, Murphy KA, Zhou M et al (2016) Codon usage
affects the structure and function of the Drosophila
circadian clock protein PERIOD. Genes Dev
30:1761–1775.
https://doi.org/10.1101/
gad.281030.116
Fuller KK, Loros JJ, Dunlap JC (2015) Fungal photobiology: visible light as a signal for stress, space and
time. Curr Genet 61:275. https://doi.org/10.1007/
s00294-014-0451-0
Galagan JE, Calvo SE, Borkovich KA et al (2003) The
genome sequence of the filamentous fungus Neurospora crassa. Nature 422:859
Gamsby JJ, Loros JJ, Dunlap JC (2009) A phylogenetically conserved DNA damage response resets the
circadian clock. J Biol Rhythm 24:193–202. https://
doi.org/10.1177/0748730409334748
Garceau NY, Liu Y, Loros JJ, Dunlap JC (1997) Alternative initiation of translation and time-specific
phosphorylation yield multiple forms of the essential clock protein FREQUENCY. Cell 89:469.
https://doi.org/10.1016/S0092-8674(00)80227-5
Gardner GF, Feldman JF (1980) The frq locus in Neurospora crassa: a key element in circadian clock
organization. Genetics 96:877–886
Gardner GF, Feldman JF (1981) Temperature compensation of circadian period length in clock mutants
of Neurospora crassa. Plant Physiol 68:1244–1248
Gaucher J, Montellier E, Sassone-Corsi P (2018) Molecular cogs: interplay between circadian clock and
cell cycle. Trends Cell Biol 28:368–379. https://doi.
org/10.1016/j.tcb.2018.01.006
Gooch V, Mehra A, Larrondo L et al (2008) Fully codonoptimized luciferase uncovers novel temperature
characteristics of the Neurospora clock. Eukaryot
Cell 7(1):28–37
Gooch VD, Johnson AE, Bourne BJ et al (2014) A kinetic
study of the effects of light on circadian rhythmicity of the frq promoter of Neurospora crassa. J Biol
Rhythm
29:38–48.
https://doi.org/10.1177/
0748730413517981
Go ¨rl M, Merrow M, Huttner B et al (2001) A PEST-like
element in FREQUENCY determines the length of
the circadian period in Neurospora crassa. EMBO J
20:7074–7084.
https://doi.org/10.1093/emboj/
20.24.7074
Greene AV, Keller N, Haas H, Bell-Pedersen D (2003) A
circadian oscillator in Aspergillus spp. regulates
daily development and gene expression. Eukaryot
Cell 2:231–237. https://doi.org/10.1128/EC.2.2.231237.2003
Grima B, Lamouroux A, Che ´lot E et al (2002) The F-box
protein Slimb controls the levels of clock proteins
period and timeless. Nature 420:178
Guo J, Cheng P, Yuan H, Liu Y (2009) The exosome
regulates circadian gene expression in a posttranscriptional negative feedback loop. Cell 138:1236–
1246. https://doi.org/10.1016/j.cell.2009.06.043
Guo J, Cheng P, Liu Y (2010) Functional significance of
FRH in regulating the phosphorylation and stability of Neurospora circadian clock protein FRQ. J
Biol Chem 285:11508–11515. https://doi.org/
10.1074/jbc.M109.071688
Gyo ¨ngyo ¨si N, Szo ˝ke A, Ella K, Ka ´ldi K (2017) The small
G protein RAS2 is involved in the metabolic compensation of the circadian clock in the circadian
model Neurospora crassa. J Biol Chem 292:14929–
14939. https://doi.org/10.1074/jbc.M117.804922
He Q, Liu Y (2005a) Degradation of the Neurospora
circadian clock protein FREQUENCY through the
ubiquitin–proteasome pathway. Biochem Soc
Trans 33:953
He Q, Liu Y (2005b) Molecular mechanism of light
responses in Neurospora: from light-induced transcription to photoadaptation. Genes Dev 19:2888–
2899. https://doi.org/10.1101/gad.1369605
He Q, Cheng P, Yang Y et al (2002) White Collar-1, a
DNA binding transcription factor and a light sensor. Science 297(80):840–843
He Q, Cheng P, Yang Y et al (2003) FWD1-mediated
degradation of FREQUENCY in Neurospora estab98
M. S. Jankowski et al.
Enabling a community to dissect an organism:
overview of the Neurospora functional genomics
project. Adv Genet 57:49–96. https://doi.org/
10.1016/S0065-2660(06)57002-6
Eide EJ, Woolf MF, Kang H et al (2005) Control of
mammalian circadian rhythm by CKI-regulated
proteasome-mediated PER2 degradation. Mol
Cell Biol 25:2795–2807. https://doi.org/10.1128/
MCB.25.7.2795-2807.2005
Emerson JM, Bartholomai BM, Ringelberg CS et al
(2015) Period-1 encodes an ATP-dependent RNA
helicase that influences nutritional compensation
of the Neurospora circadian clock. Proc Natl Acad
Sci U S A 112:15707–15712. https://doi.org/
10.1073/pnas.1521918112
Feeney KA, Hansen LL, Putker M et al (2016) Daily
magnesium fluxes regulate cellular timekeeping
and energy balance. Nature 532:375
Feldman JF, Hoyle MN (1973) Isolation of circadian
clock mutants of Neurospora crassa. Genetics
75:605–613
Filippovich SY, Bachurina GP, Shcherbakov DL (2015)
Quantitative assessment of the combined effect of
the nitrogen status, light and dehydration of mycelium on conidiation in Neurospora crassa. Appl
Biochem Microbiol 51:342–349. https://doi.org/
10.1134/S0003683815030060
Froehlich AC, Liu Y, Loros JJ, Dunlap JC (2002) White
Collar-1, a circadian blue light photoreceptor,
binding to the frequency promoter. Science 297
(80):815–819
Froehlich AC, Loros JJ, Dunlap JC (2003) Rhythmic
binding of a WHITE COLLAR-containing complex
to the frequency promoter is inhibited by FREQUENCY. Proc Natl Acad Sci U S A 100:5914–
5919. https://doi.org/10.1073/pnas.1030057100
Fu J, Murphy KA, Zhou M et al (2016) Codon usage
affects the structure and function of the Drosophila
circadian clock protein PERIOD. Genes Dev
30:1761–1775.
https://doi.org/10.1101/
gad.281030.116
Fuller KK, Loros JJ, Dunlap JC (2015) Fungal photobiology: visible light as a signal for stress, space and
time. Curr Genet 61:275. https://doi.org/10.1007/
s00294-014-0451-0
Galagan JE, Calvo SE, Borkovich KA et al (2003) The
genome sequence of the filamentous fungus Neurospora crassa. Nature 422:859
Gamsby JJ, Loros JJ, Dunlap JC (2009) A phylogenetically conserved DNA damage response resets the
circadian clock. J Biol Rhythm 24:193–202. https://
doi.org/10.1177/0748730409334748
Garceau NY, Liu Y, Loros JJ, Dunlap JC (1997) Alternative initiation of translation and time-specific
phosphorylation yield multiple forms of the essential clock protein FREQUENCY. Cell 89:469.
https://doi.org/10.1016/S0092-8674(00)80227-5
Gardner GF, Feldman JF (1980) The frq locus in Neurospora crassa: a key element in circadian clock
organization. Genetics 96:877–886
Gardner GF, Feldman JF (1981) Temperature compensation of circadian period length in clock mutants
of Neurospora crassa. Plant Physiol 68:1244–1248
Gaucher J, Montellier E, Sassone-Corsi P (2018) Molecular cogs: interplay between circadian clock and
cell cycle. Trends Cell Biol 28:368–379. https://doi.
org/10.1016/j.tcb.2018.01.006
Gooch V, Mehra A, Larrondo L et al (2008) Fully codonoptimized luciferase uncovers novel temperature
characteristics of the Neurospora clock. Eukaryot
Cell 7(1):28–37
Gooch VD, Johnson AE, Bourne BJ et al (2014) A kinetic
study of the effects of light on circadian rhythmicity of the frq promoter of Neurospora crassa. J Biol
Rhythm
29:38–48.
https://doi.org/10.1177/
0748730413517981
Go ¨rl M, Merrow M, Huttner B et al (2001) A PEST-like
element in FREQUENCY determines the length of
the circadian period in Neurospora crassa. EMBO J
20:7074–7084.
https://doi.org/10.1093/emboj/
20.24.7074
Greene AV, Keller N, Haas H, Bell-Pedersen D (2003) A
circadian oscillator in Aspergillus spp. regulates
daily development and gene expression. Eukaryot
Cell 2:231–237. https://doi.org/10.1128/EC.2.2.231237.2003
Grima B, Lamouroux A, Che ´lot E et al (2002) The F-box
protein Slimb controls the levels of clock proteins
period and timeless. Nature 420:178
Guo J, Cheng P, Yuan H, Liu Y (2009) The exosome
regulates circadian gene expression in a posttranscriptional negative feedback loop. Cell 138:1236–
1246. https://doi.org/10.1016/j.cell.2009.06.043
Guo J, Cheng P, Liu Y (2010) Functional significance of
FRH in regulating the phosphorylation and stability of Neurospora circadian clock protein FRQ. J
Biol Chem 285:11508–11515. https://doi.org/
10.1074/jbc.M109.071688
Gyo ¨ngyo ¨si N, Szo ˝ke A, Ella K, Ka ´ldi K (2017) The small
G protein RAS2 is involved in the metabolic compensation of the circadian clock in the circadian
model Neurospora crassa. J Biol Chem 292:14929–
14939. https://doi.org/10.1074/jbc.M117.804922
He Q, Liu Y (2005a) Degradation of the Neurospora
circadian clock protein FREQUENCY through the
ubiquitin–proteasome pathway. Biochem Soc
Trans 33:953
He Q, Liu Y (2005b) Molecular mechanism of light
responses in Neurospora: from light-induced transcription to photoadaptation. Genes Dev 19:2888–
2899. https://doi.org/10.1101/gad.1369605
He Q, Cheng P, Yang Y et al (2002) White Collar-1, a
DNA binding transcription factor and a light sensor. Science 297(80):840–843
He Q, Cheng P, Yang Y et al (2003) FWD1-mediated
degradation of FREQUENCY in Neurospora estab98
M. S. Jankowski et al.