149
R
H
N
R
3
R
1
R
2
O
O
HP
5 mol% AgNO 3
0.5 equiv Mg(NO 3 ) 2 ·6H 2 O
CH 3 CN,100 °C
R
N
R
1
O
R
2
R
3
O
P
N
Me
O
O
PPh 2
52%
N
Me
O
O
PPh 2
N
Me
O
O
P(OEt)Ph
43%
82%
R
4
R
5
+
R
4
R
5
N
Me
O
Bn
O
PPh 2
74%
N
Me
O
O
PPh 2
81%
OAc
N
Me
O
Ph
O
PPh 2
62%
H
N
O
H
N
O
P
Ph 2
N
O
PPh 2
O
PPh 2 H
O
PPh 2
AgNO 3
O
O
N
O
PPh 2
O
[O]
- H
Scheme 4.71 Oxidative C-P coupling through direct annulations
4 Oxidative Radical Couplings