98
140. Pastine SJ, Gribkov DV, Sames D (2006) sp(3) C-H bond arylation directed by amidine protecting group: alpha-arylation of pyrrolidines and piperidines. J Am Chem Soc
128:14220–14221
141. Giri R, Maugel N, Li J-J, Wang D-H, Breazzano SP, Saunders LB, Yu J-Q (2007) Palladiumcatalyzed methylation and arylation of sp2 and sp3 C-H bonds in simple carboxylic acids.
J Am Chem Soc 129(12):3510–3511
142. Wang D-H, Wasa M, Giri R, Yu J-Q (2008) Pd(II)-catalyzed cross-coupling of sp3 C-H bonds
with sp2 and sp3 boronic acids using air as the oxidant. J Am Chem Soc 130(23):7190–7191
143. Wasa M, Engle KM, Lin DW, Yoo EJ, Yu J-Q (2011) Pd(II)-catalyzed enantioselective C-H
activation of cyclopropanes. J Am Chem Soc 133(49):19598–19601
144. Chan KSL, Wasa M, Chu L, Laforteza BN, Miura M, Yu J-Q (2014) Ligand-enabled crosscoupling of C(sp3)-H bonds with arylboron reagents via Pd(II)/Pd(0) catalysis. Nat Chem
6(2):146–150
145. Xiao K-J, Lin DW, Miura M, Zhu R-Y, Gong W, Wasa M, Yu J-Q (2014) Palladium(II)catalyzed enantioselective C(sp3)-H activation using a chiral hydroxamic acid ligand. J Am
Chem Soc 136(22):8138–8142
146. Spangler JE, Kobayashi Y, Verma P, Wang D-H, Yu J-Q (2015) α-arylation of saturated azacycles and N-methylamines via palladium(II)-catalyzed C(sp3)-H coupling. J Am Chem Soc
137(37):11876–11879
147. Jain P, Verma P, Xia G, Yu J-Q (2017) Enantioselective amine α-functionalization via
palladium- catalysed C-H arylation of thioamides. Nat Chem 9(2):140–144
148. He C, Gaunt MJ (2015) Ligand-enabled catalytic C-H arylation of aliphatic amines by a fourmembered- ring cyclopalladation pathway. Angew Chem Int Ed 54(52):15840–15844
149. He J, Takise R, Fu H, Yu J-Q (2015) Ligand-enabled cross-coupling of C(sp3)-H bonds with
arylsilanes. J Am Chem Soc 137(14):4618–4621
150. McMurtrey KB, Racowski JM, Sanford MS (2012) Pd-Catalyzed C-H fluorination with
nucleophilic fluoride. Org Lett 14(16):4094–4097
151. Liu W, Huang X, Cheng M-J, Nielsen RJ, Goddard WA III, Groves JT (2012) Oxidative
aliphatic C-H fluorination with fluoride ion catalyzed by a manganese porphyrin. Science
337(6100):1322–1325
152. Zhang L-S, Chen G, Wang X, Guo Q-Y, Zhang X-S, Pan F, Chen K, Shi Z-J (2014) Direct
borylation of primary C-H bonds in functionalized molecules by palladium catalysis. Angew
Chem Int Ed 53(15):3899–3903
153. He J, Jiang H, Takise R, Zhu R-Y, Chen G, Dai H-X, Dhar TGM, Shi J, Zhang H, Cheng
PTW, Yu J-Q (2016) Ligand-promoted borylation of C(sp3)-H bonds with palladium(II) catalysts. Angew Chem Int Ed 55(2):785–789
154. He J, Shao Q, Wu Q, Yu J-Q (2017) Pd(II)-catalyzed enantioselective C(sp3)-H borylation.
J Am Chem Soc 139(9):3344–3347
C. He
140. Pastine SJ, Gribkov DV, Sames D (2006) sp(3) C-H bond arylation directed by amidine protecting group: alpha-arylation of pyrrolidines and piperidines. J Am Chem Soc
128:14220–14221
141. Giri R, Maugel N, Li J-J, Wang D-H, Breazzano SP, Saunders LB, Yu J-Q (2007) Palladiumcatalyzed methylation and arylation of sp2 and sp3 C-H bonds in simple carboxylic acids.
J Am Chem Soc 129(12):3510–3511
142. Wang D-H, Wasa M, Giri R, Yu J-Q (2008) Pd(II)-catalyzed cross-coupling of sp3 C-H bonds
with sp2 and sp3 boronic acids using air as the oxidant. J Am Chem Soc 130(23):7190–7191
143. Wasa M, Engle KM, Lin DW, Yoo EJ, Yu J-Q (2011) Pd(II)-catalyzed enantioselective C-H
activation of cyclopropanes. J Am Chem Soc 133(49):19598–19601
144. Chan KSL, Wasa M, Chu L, Laforteza BN, Miura M, Yu J-Q (2014) Ligand-enabled crosscoupling of C(sp3)-H bonds with arylboron reagents via Pd(II)/Pd(0) catalysis. Nat Chem
6(2):146–150
145. Xiao K-J, Lin DW, Miura M, Zhu R-Y, Gong W, Wasa M, Yu J-Q (2014) Palladium(II)catalyzed enantioselective C(sp3)-H activation using a chiral hydroxamic acid ligand. J Am
Chem Soc 136(22):8138–8142
146. Spangler JE, Kobayashi Y, Verma P, Wang D-H, Yu J-Q (2015) α-arylation of saturated azacycles and N-methylamines via palladium(II)-catalyzed C(sp3)-H coupling. J Am Chem Soc
137(37):11876–11879
147. Jain P, Verma P, Xia G, Yu J-Q (2017) Enantioselective amine α-functionalization via
palladium- catalysed C-H arylation of thioamides. Nat Chem 9(2):140–144
148. He C, Gaunt MJ (2015) Ligand-enabled catalytic C-H arylation of aliphatic amines by a fourmembered- ring cyclopalladation pathway. Angew Chem Int Ed 54(52):15840–15844
149. He J, Takise R, Fu H, Yu J-Q (2015) Ligand-enabled cross-coupling of C(sp3)-H bonds with
arylsilanes. J Am Chem Soc 137(14):4618–4621
150. McMurtrey KB, Racowski JM, Sanford MS (2012) Pd-Catalyzed C-H fluorination with
nucleophilic fluoride. Org Lett 14(16):4094–4097
151. Liu W, Huang X, Cheng M-J, Nielsen RJ, Goddard WA III, Groves JT (2012) Oxidative
aliphatic C-H fluorination with fluoride ion catalyzed by a manganese porphyrin. Science
337(6100):1322–1325
152. Zhang L-S, Chen G, Wang X, Guo Q-Y, Zhang X-S, Pan F, Chen K, Shi Z-J (2014) Direct
borylation of primary C-H bonds in functionalized molecules by palladium catalysis. Angew
Chem Int Ed 53(15):3899–3903
153. He J, Jiang H, Takise R, Zhu R-Y, Chen G, Dai H-X, Dhar TGM, Shi J, Zhang H, Cheng
PTW, Yu J-Q (2016) Ligand-promoted borylation of C(sp3)-H bonds with palladium(II) catalysts. Angew Chem Int Ed 55(2):785–789
154. He J, Shao Q, Wu Q, Yu J-Q (2017) Pd(II)-catalyzed enantioselective C(sp3)-H borylation.
J Am Chem Soc 139(9):3344–3347
C. He