Recently, further work has been described employing the 8-aminoquinoline
directing group for the efficient synthesis of cis-3-substituted proline derivatives
[46, 47], which are compounds of interests in organocatalysis [48] and drug
discovery [49–51].
Scheme 4 Total synthesis of piperarborenines via sequential Pd-catalyzed C–H arylations of a
cyclobutane core
Applications of Catalytic Organometallic C(sp
3
)–H Bond Functionalization
139
directing group for the efficient synthesis of cis-3-substituted proline derivatives
[46, 47], which are compounds of interests in organocatalysis [48] and drug
discovery [49–51].
Scheme 4 Total synthesis of piperarborenines via sequential Pd-catalyzed C–H arylations of a
cyclobutane core
Applications of Catalytic Organometallic C(sp
3
)–H Bond Functionalization
139