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Action on antitarget
Related side effects
5HT 2A receptor antagonist
Hypnotic; Sedative
5-HT 2C receptor antagonist
Obesity; Weight loss
Alpha 1a adrenergic receptor antagonist
Dizziness; Flushing; Impotence; Nasal congestion;
Postural (orthostatic) hypotension; Tachycardia;
Weakness
Alpha 1b adrenergic receptor antagonist
Ejaculation dysfunction
Alpha 2a adrenergic receptor antagonist
Anxiety; Depression
Androgen receptor antagonist
Virilization; gynecomastia; hepatic pelioza;
hepatoma
Carbonic anhydrase inhibition
Acidosis, metabolic; Alopecia (hair loss); Anaphylaxis; Anemia, aplastic; Anxiety; Bone marrow
suppression; Chronic fatigue syndrome; Confusion;
Corneal edema; Depression; Dyspepsia; Dysphagia;
Impotence; Irritation; Keratitis; Malaise; Nausea;
Nephrotoxic; Neuroprotector; Paralysis; Pulmonary
edema; Renal tubular acidosis; Stevens-Johnson
syndrome; Taste disturbance; Thrombocytopenia;
Urinary stone; Vision blurring; Weight loss
Estrogen receptor antagonist
Depression; Headache; Obesity; Sickness; Hot
flashes; Puffiness
Delta-type opioid receptor antagonist
Reverse analgesia; Opioid withdrawal symptoms
MAO A inhibitor
Blood pressure lability; Bradycardia; Chorea;
Convulsions; Delirium; Diarrhea; Hepatotoxicity;
Drowsiness
Mu-type opioid receptor antagonist
Laxative
Sodium- and chloride-dependent GABA
transporter 1 inhibitor
Neurotoxicity
Sodium-dependent dopamine transporter
inhibitor
Neurotoxicity
Sodium-dependent serotonin transporter
inhibitor
Acute respiratory distress syndrome (ARDS);
Agitation; Akathisia; Anorgasmia; Antialcoholic;
Constipation; Convulsant; Diarrhea; Dizziness;
Drowsiness; Dysesthesia; Dyskinesia; Dystonia;
Ecchymosis; Ejaculation dysfunction; Emetic;
Epistaxis; Exanthema; Extrapyramidal effect; Glaucoma; Hallucination, visual; Headache; Hemorrhage; Hepatotoxic; Hormone secretion (SIADH);
Hot flush; Hyperprolactinemia; Hypersexuality; Hypertensive; Hypoglycemic; Hypomania;
Hyponatremia; Hypothermic; Insomnia; Ischemic
colitis; Mania; Menorrhagia; Myoclonus; Nausea;
Neuroleptic malignant syndrome; Panic; Parkinsonism; Purpura; QT interval prolongation; Serotonin
syndrome; Sexual dysfunction; Shivering; Sleep
disturbance; Stevens-Johnson syndrome; Sweating;
Syncope; Taste disturbance; Thrombocytopenia;
Tremor; Weight gain; Weight loss; Xerostomia
Table 11.10  Relationships between drug action on antitargets and adverse side effects from
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