291
9 Polyphenol Glycosides as Potential Remedies in Kidney …
that glycosides are characterized by higher ability to form complexes in the
comparison to their glycon or aglycon parts alone. The findings indicate that
the complexation process proceeds by both part simultaneously. Data for the
gas phase show that the interaction energy strongly depends on the coordination number. However computations including the solvent effect indicate the
influence of importance of other interactions. The inclusion of the solvent effect increases the contribution of conformational effects of carbohydrate part
into the stability of complexes. The studies of glycosides with the potential
complexation ability still need optimization of structural parameters responsible for these properties.
Acknowledgments This work was supported by the statutory activity subsidy from Polish Ministry of Science and Technology of Higher Education for the Faculty of Chemistry of Wroclaw
University of Technology. The computations were performed in Wroclaw Supercomputing and
Networking Center.
References
1. Sejersted OM (2011) Calcium controls cardiac function—by all means! J Physiol
589(12):2919–2920. doi:10.1113/jphysiol.2011.210989
2. Lovelock JE, Porterfield BM (1952) Blood clotting: the function of electrolytes and of calcium. Biochemistry 50:415–420
3. Peacock M (2010) Calcium metabolism in health and disease. Clin J Am Soc Nephrol 5:S23–
S30. doi:10.2215/CJN.05910809
4. Endo M (2006) Calcium ion as a second messenger with special reference to excitation–contraction coupling. J Pharmacol Sci 100:519–524. doi:10.1254/jphs.CPJ06004X
5. Moe OW (2006) Kidney stones: pathophysiology and medical management. Lancet 367:333–
344. doi:10.1016/S0140-6736(06)68071-9
6. Lewandowski S, Rodgers AL (2004) Idiopathic calcium oxalate urolithiasis: risk factors and
conservative treatment. Clin Chim Acta 345:17–34. doi:10.1016/j.cccn.2004.03.009
7. Coe FL, Evan A, Worcester E (2005) Kidney stone disease. J Clin Invest 115(10):2598–2608.
doi:10.1172/JCI26662
8. Hall PM (2009) Nephrolithiasis: treatment, causes, and prevention. Cleve Clin J Med
76(10):583–591. doi:10.3949/ccjm.76a.09043
9. Kaufman Katz A, Glusker JP, Beebe SA, Bock CW (1996) Calcium ion coordination: a
comparison with that of beryllium, magnesium, and zinc. J Am Chem Soc 118:5752–5763.
doi:10.1021/ja953943i
10. Nakanishi F, Nagasawa Y, Kabaya Y, Sekimoto H, Shimomura K (2005) Characterization of
lucidin formation in Rubia tinctorum L. Plant Physiol Biochem 43:921–928. doi:10.1016/j.
plaphy.2005.08.005
11. Gyurcsik B, Nagy L (2000) Carbohydrates as ligands: coordination equilibria and structure of
the metal complexes. Coord Chem Rev 203:81–149. doi:10.1016/S0010-8545(99)00183-6
12. Alekseev YE, Garnovskii AD, Zhdanov YA (1998) Complexes of natural carbohydrates with
metal cations. Russ Chem Rev 67(8):649–669.
13. Bugg CE, Cook WJ (1972) Calcium ion binding to uncharged sugars: crystal structures of
calcium bromide complexes of lactose, galactose, and inositol. J Chem Soc Chem Commun
12:727–729. doi:10.1039/C39720000727
14. Bugg CE (1973) Calcium binding to carbohydrates. Crystal structure of a hydrates calcium
bromide complex of lactose. J Am Chem Soc 95:908–913. doi:10.1021/ja00784a046
9 Polyphenol Glycosides as Potential Remedies in Kidney …
that glycosides are characterized by higher ability to form complexes in the
comparison to their glycon or aglycon parts alone. The findings indicate that
the complexation process proceeds by both part simultaneously. Data for the
gas phase show that the interaction energy strongly depends on the coordination number. However computations including the solvent effect indicate the
influence of importance of other interactions. The inclusion of the solvent effect increases the contribution of conformational effects of carbohydrate part
into the stability of complexes. The studies of glycosides with the potential
complexation ability still need optimization of structural parameters responsible for these properties.
Acknowledgments This work was supported by the statutory activity subsidy from Polish Ministry of Science and Technology of Higher Education for the Faculty of Chemistry of Wroclaw
University of Technology. The computations were performed in Wroclaw Supercomputing and
Networking Center.
References
1. Sejersted OM (2011) Calcium controls cardiac function—by all means! J Physiol
589(12):2919–2920. doi:10.1113/jphysiol.2011.210989
2. Lovelock JE, Porterfield BM (1952) Blood clotting: the function of electrolytes and of calcium. Biochemistry 50:415–420
3. Peacock M (2010) Calcium metabolism in health and disease. Clin J Am Soc Nephrol 5:S23–
S30. doi:10.2215/CJN.05910809
4. Endo M (2006) Calcium ion as a second messenger with special reference to excitation–contraction coupling. J Pharmacol Sci 100:519–524. doi:10.1254/jphs.CPJ06004X
5. Moe OW (2006) Kidney stones: pathophysiology and medical management. Lancet 367:333–
344. doi:10.1016/S0140-6736(06)68071-9
6. Lewandowski S, Rodgers AL (2004) Idiopathic calcium oxalate urolithiasis: risk factors and
conservative treatment. Clin Chim Acta 345:17–34. doi:10.1016/j.cccn.2004.03.009
7. Coe FL, Evan A, Worcester E (2005) Kidney stone disease. J Clin Invest 115(10):2598–2608.
doi:10.1172/JCI26662
8. Hall PM (2009) Nephrolithiasis: treatment, causes, and prevention. Cleve Clin J Med
76(10):583–591. doi:10.3949/ccjm.76a.09043
9. Kaufman Katz A, Glusker JP, Beebe SA, Bock CW (1996) Calcium ion coordination: a
comparison with that of beryllium, magnesium, and zinc. J Am Chem Soc 118:5752–5763.
doi:10.1021/ja953943i
10. Nakanishi F, Nagasawa Y, Kabaya Y, Sekimoto H, Shimomura K (2005) Characterization of
lucidin formation in Rubia tinctorum L. Plant Physiol Biochem 43:921–928. doi:10.1016/j.
plaphy.2005.08.005
11. Gyurcsik B, Nagy L (2000) Carbohydrates as ligands: coordination equilibria and structure of
the metal complexes. Coord Chem Rev 203:81–149. doi:10.1016/S0010-8545(99)00183-6
12. Alekseev YE, Garnovskii AD, Zhdanov YA (1998) Complexes of natural carbohydrates with
metal cations. Russ Chem Rev 67(8):649–669.
13. Bugg CE, Cook WJ (1972) Calcium ion binding to uncharged sugars: crystal structures of
calcium bromide complexes of lactose, galactose, and inositol. J Chem Soc Chem Commun
12:727–729. doi:10.1039/C39720000727
14. Bugg CE (1973) Calcium binding to carbohydrates. Crystal structure of a hydrates calcium
bromide complex of lactose. J Am Chem Soc 95:908–913. doi:10.1021/ja00784a046