Chapter 11
Segmentation and Visualization
of Drusen and Geographic Atrophy
in SD-OCT Images
Qiang Chen, Sijie Niu, Luis de Sisternes, Theodore Leng and Daniel L. Rubin
Age-related macular degeneration (AMD) is a major cause of vision loss for elderly
people. Drusen and geographic atrophy are two kinds of pathological changes associated with AMD. This chapter presents several methods that achieve abnormal region
segmentation for quantitative analysis or enhanced visualization for better qualitative
assessment.
11.1 Introduction
Age-related macular degeneration (AMD) is the most common cause of visual
impairment among the elderly in developed countries [1]. AMD is a degenerative
eye disease that robs a person of their central vision while typically leaving their
peripheral vision unaffected (i.e. degenerate the macula). The macula is the central,
posterior portion of the retina. It contains the densest concentration of photo-receptors
within the retina and is responsible for central high-resolution visual acuity, allowing
a person to see fine detail, read, and recognize faces [2]. AMD can be classified into
Q. Chen (B)
School of Computer Science and Engineering, Nanjing University of Science and Technology,
Nanjing, China
e-mail: chen2qiang@njust.edu.cn
S. Niu
School of Information Science and Engineering, University of Jinan, Jinan, China
L. de Sisternes · D. L. Rubin
Department of Radiology, Stanford University, Stanford, USA
T. Leng
Byers Eye Institute at Stanford, Stanford University School of Medicine, Palo Alto, USA
D. L. Rubin
Department of Medicine (Biomedical Informatics), Stanford University, Stanford, USA
© Science Press and Springer Nature Singapore Pte Ltd. 2019
X. Chen et al. (eds.), Retinal Optical Coherence Tomography Image Analysis,
Biological and Medical Physics, Biomedical Engineering,
https://doi.org/10.1007/978-981-13-1825-2_11
281
Segmentation and Visualization
of Drusen and Geographic Atrophy
in SD-OCT Images
Qiang Chen, Sijie Niu, Luis de Sisternes, Theodore Leng and Daniel L. Rubin
Age-related macular degeneration (AMD) is a major cause of vision loss for elderly
people. Drusen and geographic atrophy are two kinds of pathological changes associated with AMD. This chapter presents several methods that achieve abnormal region
segmentation for quantitative analysis or enhanced visualization for better qualitative
assessment.
11.1 Introduction
Age-related macular degeneration (AMD) is the most common cause of visual
impairment among the elderly in developed countries [1]. AMD is a degenerative
eye disease that robs a person of their central vision while typically leaving their
peripheral vision unaffected (i.e. degenerate the macula). The macula is the central,
posterior portion of the retina. It contains the densest concentration of photo-receptors
within the retina and is responsible for central high-resolution visual acuity, allowing
a person to see fine detail, read, and recognize faces [2]. AMD can be classified into
Q. Chen (B)
School of Computer Science and Engineering, Nanjing University of Science and Technology,
Nanjing, China
e-mail: chen2qiang@njust.edu.cn
S. Niu
School of Information Science and Engineering, University of Jinan, Jinan, China
L. de Sisternes · D. L. Rubin
Department of Radiology, Stanford University, Stanford, USA
T. Leng
Byers Eye Institute at Stanford, Stanford University School of Medicine, Palo Alto, USA
D. L. Rubin
Department of Medicine (Biomedical Informatics), Stanford University, Stanford, USA
© Science Press and Springer Nature Singapore Pte Ltd. 2019
X. Chen et al. (eds.), Retinal Optical Coherence Tomography Image Analysis,
Biological and Medical Physics, Biomedical Engineering,
https://doi.org/10.1007/978-981-13-1825-2_11
281