180
E. Gao et al.
Table 7.3 Macular optical intensity in ETDRS regions
Retinal
layers
Cen
Inner ring
Sin
Nin
Lin
Tin
RNFL
24,102.52 ± 1251
30,843.87 ± 1384
29,839.42 ± 1422
30,687.22 ± 1322
29,005.43 ± 1545
RGCL
25,053.23 ± 1124
26,148.73 ± 1131
25,942.91 ± 1061
25,876.91 ± 1091
25,798.12 ± 1064
IPL
25,903.58 ± 1137
26,641.79 ± 1126
26,615.80 ± 1064
26,336.48 ± 1096
26,583.51 ± 1055
INL
24,052.05 ± 1133
23,625.45 ± 1076
23,624.06 ± 1012
23,300.45 ± 1047
23,619.90 ± 1006
OPL
24,023.62 ± 1217
25,261.45 ± 1120
25,256.25 ± 1038
24,893.74 ± 1094
25,194.93 ± 1093
ONL
21,486.65 ± 975
21,807.71 ± 1015
21,652.77 ± 961
21,569.35 ± 1013
21,617.72 ± 971
PR
31,574.06 ± 1734
32,899.26 ± 1859
32,778.81 ± 2176
32,590.06 ± 2165
33,227.47 ± 1839
RPE
36,030.78 ± 1070
35,443.49 ± 1003
35,489.23 ± 1103
35,060.54 ± 1218
35,672.81 ± 983
Retinal
layers
Outer ring
Whole ETDRS
Sout
Nout
Iout
Tout
RNFL
32,285.48 ± 1480
32,742.87 ± 1521
31,618.63 ± 1231
29,972.42 ± 1564
31,558.68 ± 1098
RGCL
27,122.16 ± 1257
26,911.89 ± 1121
26,825.53 ± 1040
26,494.2 ± 1156
26,653.71 ± 896
IPL
26,852.89 ± 1275
26,799.34 ± 1111
26,397.12 ± 1032
26,788.47 ± 1141
26,677.85 ± 903
INL
23,603.41 ± 1178
23,563.84 ± 1039
23,141.81 ± 963
23,692.28 ± 1064
23,538.66 ± 876
OPL
24,926.75 ± 1242
25,050.16 ± 1084
24,343.63 ± 1057
25,121.60 ± 1125
24,824.14 ± 933
ONL
21,377.63 ± 1029
21,406.76 ± 944
20,987.83 ± 882
21,605.05 ± 943
21,381.69 ± 794
PR
31,920.69 ± 1905
31,902.14 ± 2123
31,221.00 ± 1843
32,614.52 ± 1723
31,759.63 ± 1445
RPE
34,686.48 ± 1048
34,707.6 ± 1102
33,936.19 ± 1058
35,206.9 ± 900
34,677.20 ± 696
7.4.4 Determinants of Retinal Optical Intensity
Differences between men and women in mean optical intensity were not significant (all p < 0.05, independent-samples t-test). The results of Pearson correlation
analysis between optical intensity and age, height, weight, spherical equivalent,
axial length, image quality, disc area and rim/disc area ratio. Image quality was
significantly correlated with all retinal layer optical intensities, with the correlation
coefficient r ranging from 0.503 to 0.851 (all p < 0.01). Age was negatively correlated with optical intensity from RNFL to photoreceptor layer (−0.517 < r<−0.242,
p < 0.01), but positively correlated with that in RPE (r 0.287, p < 0.01). Axial
length was also negatively correlated with optical intensity from OPL to RPE.
Spherical equivalent was positively correlated with only ONL and RPE optical intensity. The relationship of disc area and optical intensity in most layers
was weak but significant in RPE layer. No statistically significant relationships
were found between retinal optical intensity and height, weight and rim/disc area
ratio.
The results of stepwise multiple linear regression analysis was calculated. Factors
significant at p < 0.05 with any retinal layer optical intensity from the univariate
analysis were included. Significant determinants of optical intensity for most retinal
layers were age and image quality. The effect of image quality was more pronounced
in the optical intensity of ONL (β 0.851), followed by INL, OPL and IPL, and was
E. Gao et al.
Table 7.3 Macular optical intensity in ETDRS regions
Retinal
layers
Cen
Inner ring
Sin
Nin
Lin
Tin
RNFL
24,102.52 ± 1251
30,843.87 ± 1384
29,839.42 ± 1422
30,687.22 ± 1322
29,005.43 ± 1545
RGCL
25,053.23 ± 1124
26,148.73 ± 1131
25,942.91 ± 1061
25,876.91 ± 1091
25,798.12 ± 1064
IPL
25,903.58 ± 1137
26,641.79 ± 1126
26,615.80 ± 1064
26,336.48 ± 1096
26,583.51 ± 1055
INL
24,052.05 ± 1133
23,625.45 ± 1076
23,624.06 ± 1012
23,300.45 ± 1047
23,619.90 ± 1006
OPL
24,023.62 ± 1217
25,261.45 ± 1120
25,256.25 ± 1038
24,893.74 ± 1094
25,194.93 ± 1093
ONL
21,486.65 ± 975
21,807.71 ± 1015
21,652.77 ± 961
21,569.35 ± 1013
21,617.72 ± 971
PR
31,574.06 ± 1734
32,899.26 ± 1859
32,778.81 ± 2176
32,590.06 ± 2165
33,227.47 ± 1839
RPE
36,030.78 ± 1070
35,443.49 ± 1003
35,489.23 ± 1103
35,060.54 ± 1218
35,672.81 ± 983
Retinal
layers
Outer ring
Whole ETDRS
Sout
Nout
Iout
Tout
RNFL
32,285.48 ± 1480
32,742.87 ± 1521
31,618.63 ± 1231
29,972.42 ± 1564
31,558.68 ± 1098
RGCL
27,122.16 ± 1257
26,911.89 ± 1121
26,825.53 ± 1040
26,494.2 ± 1156
26,653.71 ± 896
IPL
26,852.89 ± 1275
26,799.34 ± 1111
26,397.12 ± 1032
26,788.47 ± 1141
26,677.85 ± 903
INL
23,603.41 ± 1178
23,563.84 ± 1039
23,141.81 ± 963
23,692.28 ± 1064
23,538.66 ± 876
OPL
24,926.75 ± 1242
25,050.16 ± 1084
24,343.63 ± 1057
25,121.60 ± 1125
24,824.14 ± 933
ONL
21,377.63 ± 1029
21,406.76 ± 944
20,987.83 ± 882
21,605.05 ± 943
21,381.69 ± 794
PR
31,920.69 ± 1905
31,902.14 ± 2123
31,221.00 ± 1843
32,614.52 ± 1723
31,759.63 ± 1445
RPE
34,686.48 ± 1048
34,707.6 ± 1102
33,936.19 ± 1058
35,206.9 ± 900
34,677.20 ± 696
7.4.4 Determinants of Retinal Optical Intensity
Differences between men and women in mean optical intensity were not significant (all p < 0.05, independent-samples t-test). The results of Pearson correlation
analysis between optical intensity and age, height, weight, spherical equivalent,
axial length, image quality, disc area and rim/disc area ratio. Image quality was
significantly correlated with all retinal layer optical intensities, with the correlation
coefficient r ranging from 0.503 to 0.851 (all p < 0.01). Age was negatively correlated with optical intensity from RNFL to photoreceptor layer (−0.517 < r<−0.242,
p < 0.01), but positively correlated with that in RPE (r 0.287, p < 0.01). Axial
length was also negatively correlated with optical intensity from OPL to RPE.
Spherical equivalent was positively correlated with only ONL and RPE optical intensity. The relationship of disc area and optical intensity in most layers
was weak but significant in RPE layer. No statistically significant relationships
were found between retinal optical intensity and height, weight and rim/disc area
ratio.
The results of stepwise multiple linear regression analysis was calculated. Factors
significant at p < 0.05 with any retinal layer optical intensity from the univariate
analysis were included. Significant determinants of optical intensity for most retinal
layers were age and image quality. The effect of image quality was more pronounced
in the optical intensity of ONL (β 0.851), followed by INL, OPL and IPL, and was