7 Quantitative Analysis of Retinal Layers’ Optical Intensities …
175
Fig. 7.4 Correlation of optical intensity in retinal nerve fiber layer with age
image quality index were 51.8 ± 8.3. The image quality index had strong correlation
with optical intensities of retinal layers (r between 0.748 and 0.973, p < 10
−8 ), but
moderate correlation with vitreous intensity (r 0.528, p 0.0005). Age was not correlated with optical intensities in any layers except RNFL, which has r −0.365, p
0.021 (Fig. 7.4). The correlation remained significant after adjust of image quality
(b −24.2, p 0.025).
7.3.4 Discussion
This analysis is based on 3D data and investigated all retinal layers, therefore provided
complete profile of the scanned area. Furthermore, this study is fully automatic,
which eliminated inter-observer variation. Although the study used the data from
Topcon 3D-OCT 1000, the algorithm can be applied to SD-OCT images from any
manufacturer.
It is found in the study that the optical intensities in different layers correlated with
each other. They were also strongly correlated with image quality, which represented
signal strength in Topcon 3D-OCT 1000. Therefore, the study confirmed that optical
intensity was affected by the signal strength.
175
Fig. 7.4 Correlation of optical intensity in retinal nerve fiber layer with age
image quality index were 51.8 ± 8.3. The image quality index had strong correlation
with optical intensities of retinal layers (r between 0.748 and 0.973, p < 10
−8 ), but
moderate correlation with vitreous intensity (r 0.528, p 0.0005). Age was not correlated with optical intensities in any layers except RNFL, which has r −0.365, p
0.021 (Fig. 7.4). The correlation remained significant after adjust of image quality
(b −24.2, p 0.025).
7.3.4 Discussion
This analysis is based on 3D data and investigated all retinal layers, therefore provided
complete profile of the scanned area. Furthermore, this study is fully automatic,
which eliminated inter-observer variation. Although the study used the data from
Topcon 3D-OCT 1000, the algorithm can be applied to SD-OCT images from any
manufacturer.
It is found in the study that the optical intensities in different layers correlated with
each other. They were also strongly correlated with image quality, which represented
signal strength in Topcon 3D-OCT 1000. Therefore, the study confirmed that optical
intensity was affected by the signal strength.