61
Table 2 Solubilization of small molecules in deep eutectic solvents
Compound
Pharmaceutical
activity
Optimal deep eutectic
solvent composition(s)
Therapeutic
deep
eutectic
solvents
References
1,8-dihydroxyl
anthraquinone
Natural product LA:G:W 5:1:3
Dai et al.
(2013)
Acetaminophen
Analgesic and
antipyretic
TPAB:PD 1:2
Lu et al. (2016)
Acetaminophen
Analgesic and
antipyretic
CC:U 1:2; CC:MOA 1:1;
CC:OA 1:1,; CC:GL 1:2;
CC:EG1:2
Shekaari et al.
(2017, 2018a)
Adiphenine
Local anesthetic Drug with GL, U, or
aspirin
✓
Abbott et al.
(2017)
AMG517
Transient
receptor
potential
vanilloid 1
antagonist
MOA:CC 1:1
Morrison et al.
(2009)
Antofloxacin
Antibiotic
CC:p-toluenesulfonic
acid 1:2
Zhang et al.
(2019)
Aspirin
(acetylsalicylic
acid)
Antiinflammatory
CC:drug and
menthol:drug
✓
Aroso et al.
(2016)
Aspirin
(acetylsalicylic
acid)
Antiinflammatory
TPAB:PD 1:2
Lu et al. (2016)
Aspirin
(acetylsalicylic
acid)
Antiinflammatory
CC:drug
✓
Abbott et al.
(2017)
Aspirin
(acetylsalicylic
acid)
Antiinflammatory
CC:drug
✓
Abranches
et al. (2019)
Benzalkonium
chloride
Antiseptic
Drug:AA
✓
Wang et al.
(2017)
Benzoic acid
Model drug
CC:U 1:2
Morrison et al.
(2009)
Benzoic acid
Model drug
CC:drug and
menthol:drug
✓
Aroso et al.
(2016) and
Duarte et al.
(2017)
Berberine
Various (natural
alkaloid)
P:MA:LA:W
1:0.2:0.3:0.5
Sut et al.
(2017)
bis(2-ethylhexyl)
2-(4-hydroxy-3,5dimethoxybenzyl)
malonate
(Bis-EHBm)
Antioxidant
PD:CC:W1:1:1
Durand et al.
(2017)
(continued)
2 Deep Eutectic Solvents for Innovative Pharmaceutical Formulations