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© The Editor(s) (if applicable) and The Author(s), under exclusive license to
Springer Nature Switzerland AG 2021
S. Fourmentin et al. (eds.), Deep Eutectic Solvents for Medicine, Gas
Solubilization and Extraction of Natural Substances, Environmental Chemistry
for a Sustainable World 56, https://doi.org/10.1007/978-3-030-53069-3_2
Chapter 2
Deep Eutectic Solvents for Innovative
Pharmaceutical Formulations
Canh-Hung Nguyen, Luc Augis, Sophie Fourmentin, Gillian Barratt,
and François-Xavier Legrand
Contents
2.1 Introduction
43
2.1.1 Definitions and Components
44
2.1.2 Physicochemical Properties: Characterization of Deep Eutectic Solvents
44
2.2 Toxicity of Deep Eutectic Solvents
45
2.2.1 Toxicity Toward Microorganisms
45
2.2.2 Toxicity Toward Human Cells Lines and Ex Vivo Studies on Skin
50
2.2.3 Toxicity Toward Plants, Invertebrates, and Fish
54
2.2.4 In Vivo Toxicity in Rodents
55
2.2.5 Attempts to Predict Toxicity of Deep Eutectic Solvents
57
2.3 Pharmaceutical Applications of Deep Eutectic Solvents
58
2.3.1 Solubilization of Small Molecules in Deep Eutectic Solvents
58
2.3.2 Solubilization and Stabilization of High- Molecular-Weight Molecules
71
2.3.3 Antimicrobial Applications
79
2.3.4 Cutaneous Applications
84
2.3.5 Oral Applications
88
2.3.6 Nasal Applications
92
2.3.7 Applications in Formulation for Drug Delivery and Biotechnology
92
2.4 Conclusions
95
References
95
C.-H. Nguyen
Université Paris-Saclay, CNRS UMR 8612, Institut Galien Paris-Saclay,
Châtenay-Malabry, France
Department of Pharmaceutics, Hanoi University of Pharmacy, Hanoi, Vietnam
L. Augis · G. Barratt (*) · F.-X. Legrand (*)
Université Paris-Saclay, CNRS UMR 8612, Institut Galien Paris-Saclay,
Châtenay-Malabry, France
e-mail: gillian.barratt@universite-paris-saclay.fr;
francois-xavier.legrand@universite-paris-saclay.fr
S. Fourmentin
Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV, UR 4492), SFR
Condorcet FR CNRS 3417, Université du Littoral Côte d’Opale, Dunkerque, France