175
threonine, achieving a 31.6% enantiomeric excess in a single stage separation
(Wang et al. 2019).
5.4 Outlook
In conclusion, some encouraging preliminary results on the design and application
of hydrophobic deep eutectic solvents have been reported in this new and rapidly
developing field. It has a significant potential and is expected to flourish in the
future, developing innovative hydrophobic deep eutectic solvents, with better tailored functionalities and improved performances. It has been demonstrated that
functional tailored-to-application liquids can be formulated by mixing two or more
components to obtain a room temperature liquid, expanding beyond definitions for
either ionic liquids or deep eutectic solvents. Going forward, it is crucial to maintain
continuity with the decades of knowledge accumulated in areas such as liquid- liquid
extraction of biomolecules from aqueous feeds. For example, to understand how
specific hydrophobic deep eutectic solvents perform in relation to octanol-water
partitioning in order to build on the past knowledge of efficient extractants, combined with ionic liquids/deep eutectic solvents knowledge, to formulate functional
liquids.
References
Abbott AP, Capper G, Davies DL, Rasheed RK, Tambyrajah V (2003) Novel solvent properties
of choline chloride/urea mixtures. Chem Commun:70–71. https://doi.org/10.1039/b210714g
Abbott AP, Boothby D, Capper G, Davies DL, Rasheed R (2004) Deep eutectic solvents formed
between choline chloride and carboxylic acids: versatile alternatives to ionic liquids. J Am
Chem Soc 126(29):9142–9147. https://doi.org/10.1021/ja048266j
Ahmadi R, Kazemi G, Ramezani AM, Safavi A (2019) Shaker-assisted liquid-liquid microextraction of methylene blue using deep eutectic solvent followed by back-extraction and
spectrophotometric determination. Microchem J 145:501–507. https://doi.org/10.1016/j.
microc.2018.11.005
Akramipour R, Golpayegani MR, Ghasemi M, Noori N, Fattahi N (2019) Development of an
efficient sample preparation method for the speciation of Se (IV)/ Se (VI) and total inorganic
selenium in blood of children with acute leukemia. New J Chem 43:6951–6958. https://doi.
org/10.1039/c9nj00979e
Araujo CF, Coutinho JAP, Nolasco MM, Parker SF, Ribeiro-Claro PJA, Rudic S, Soares BIG,
Vaz PD (2017) Inelastic neutron scattering study of reline: shedding light on the hydrogen
bonding network of deep eutectic solvents. Phys Chem Chem Phys 19:17998–18009. https://
doi.org/10.1039/c7cp01286a
Ashworth CR, Matthews RP, Welton T, Hunt PA (2016) Doubly ionic hydrogen bond interactions within the choline chloride – urea deep eutectic solvent. Phys Chem Chem Phys
18:18145–18160. https://doi.org/10.1039/C6CP02815B
Bayliss C, Langley K (2003) Nuclear decommissioning, waste management, and environmental
site remediation. Elsevier, Burlington
5 Hydrophobic Deep Eutectic Solvents
threonine, achieving a 31.6% enantiomeric excess in a single stage separation
(Wang et al. 2019).
5.4 Outlook
In conclusion, some encouraging preliminary results on the design and application
of hydrophobic deep eutectic solvents have been reported in this new and rapidly
developing field. It has a significant potential and is expected to flourish in the
future, developing innovative hydrophobic deep eutectic solvents, with better tailored functionalities and improved performances. It has been demonstrated that
functional tailored-to-application liquids can be formulated by mixing two or more
components to obtain a room temperature liquid, expanding beyond definitions for
either ionic liquids or deep eutectic solvents. Going forward, it is crucial to maintain
continuity with the decades of knowledge accumulated in areas such as liquid- liquid
extraction of biomolecules from aqueous feeds. For example, to understand how
specific hydrophobic deep eutectic solvents perform in relation to octanol-water
partitioning in order to build on the past knowledge of efficient extractants, combined with ionic liquids/deep eutectic solvents knowledge, to formulate functional
liquids.
References
Abbott AP, Capper G, Davies DL, Rasheed RK, Tambyrajah V (2003) Novel solvent properties
of choline chloride/urea mixtures. Chem Commun:70–71. https://doi.org/10.1039/b210714g
Abbott AP, Boothby D, Capper G, Davies DL, Rasheed R (2004) Deep eutectic solvents formed
between choline chloride and carboxylic acids: versatile alternatives to ionic liquids. J Am
Chem Soc 126(29):9142–9147. https://doi.org/10.1021/ja048266j
Ahmadi R, Kazemi G, Ramezani AM, Safavi A (2019) Shaker-assisted liquid-liquid microextraction of methylene blue using deep eutectic solvent followed by back-extraction and
spectrophotometric determination. Microchem J 145:501–507. https://doi.org/10.1016/j.
microc.2018.11.005
Akramipour R, Golpayegani MR, Ghasemi M, Noori N, Fattahi N (2019) Development of an
efficient sample preparation method for the speciation of Se (IV)/ Se (VI) and total inorganic
selenium in blood of children with acute leukemia. New J Chem 43:6951–6958. https://doi.
org/10.1039/c9nj00979e
Araujo CF, Coutinho JAP, Nolasco MM, Parker SF, Ribeiro-Claro PJA, Rudic S, Soares BIG,
Vaz PD (2017) Inelastic neutron scattering study of reline: shedding light on the hydrogen
bonding network of deep eutectic solvents. Phys Chem Chem Phys 19:17998–18009. https://
doi.org/10.1039/c7cp01286a
Ashworth CR, Matthews RP, Welton T, Hunt PA (2016) Doubly ionic hydrogen bond interactions within the choline chloride – urea deep eutectic solvent. Phys Chem Chem Phys
18:18145–18160. https://doi.org/10.1039/C6CP02815B
Bayliss C, Langley K (2003) Nuclear decommissioning, waste management, and environmental
site remediation. Elsevier, Burlington
5 Hydrophobic Deep Eutectic Solvents