103
© The Editor(s) (if applicable) and The Author(s), under exclusive license to
Springer Nature Switzerland AG 2021
S. Fourmentin et al. (eds.), Deep Eutectic Solvents for Medicine, Gas
Solubilization and Extraction of Natural Substances, Environmental Chemistry
for a Sustainable World 56, https://doi.org/10.1007/978-3-030-53069-3_3
Chapter 3
Therapeutic Deep Eutectic Systems
for the Enhancement of Drug
Bioavailability
Filipa Santos and Ana Rita C. Duarte
Contents
3.1 Introduction
105
3.2 History of Green Solvents and Evolution Until Therapeutic Deep Eutectic Systems
106
3.2.1 Eutectics in Pharmacy
108
3.2.2 Advantages of Using Eutectics in Pharmacy
110
3.2.3 Different Methods for Preparation of Therapeutic Deep Eutectic Systems
112
3.2.4 Characterization of Therapeutic Deep Eutectic Systems
113
3.3 Applications of Therapeutic Deep Eutectic Systems in Research and Industry
117
3.3.1 Therapeutic Deep Eutectic Systems for Improvement of the Bioavailability
of Drugs
117
3.3.2 Biomedical Formulation with Therapeutic Deep Eutectic Systems
120
3.3.3 Future Perspectives
122
3.4 Conclusion
124
References
124
Abstract Nowadays, green and sustainable approaches are one of the principles
that companies have presented in their products and processes, and the pharmaceutical industry is not an exception. A constant search for new developments that
allow the use of methods with minor risks to the environment is a transversal concern throughout the industry. For pharmaceutical and biomedical companies, green
chemistry is a principle to have in mind, particularly in their search for new substances or matrices to deliver drugs or solve problems of solubility, polymorphism,
toxicity, bioavailability, and pharmacokinetic. Currently, despite the investment on
research and development, it is increasingly difficult to find new molecules to substitute the “old” ones with enhanced therapeutic efficacy. Because of that, the
F. Santos · A. R. C. Duarte (*)
LAQV, REQUIMTE, Departamento de Química da Faculdade de Ciências e Tecnologia,
Universidade Nova de Lisboa, Caparica, Portugal
e-mail: aduarte@fct.unl.pt
© The Editor(s) (if applicable) and The Author(s), under exclusive license to
Springer Nature Switzerland AG 2021
S. Fourmentin et al. (eds.), Deep Eutectic Solvents for Medicine, Gas
Solubilization and Extraction of Natural Substances, Environmental Chemistry
for a Sustainable World 56, https://doi.org/10.1007/978-3-030-53069-3_3
Chapter 3
Therapeutic Deep Eutectic Systems
for the Enhancement of Drug
Bioavailability
Filipa Santos and Ana Rita C. Duarte
Contents
3.1 Introduction
105
3.2 History of Green Solvents and Evolution Until Therapeutic Deep Eutectic Systems
106
3.2.1 Eutectics in Pharmacy
108
3.2.2 Advantages of Using Eutectics in Pharmacy
110
3.2.3 Different Methods for Preparation of Therapeutic Deep Eutectic Systems
112
3.2.4 Characterization of Therapeutic Deep Eutectic Systems
113
3.3 Applications of Therapeutic Deep Eutectic Systems in Research and Industry
117
3.3.1 Therapeutic Deep Eutectic Systems for Improvement of the Bioavailability
of Drugs
117
3.3.2 Biomedical Formulation with Therapeutic Deep Eutectic Systems
120
3.3.3 Future Perspectives
122
3.4 Conclusion
124
References
124
Abstract Nowadays, green and sustainable approaches are one of the principles
that companies have presented in their products and processes, and the pharmaceutical industry is not an exception. A constant search for new developments that
allow the use of methods with minor risks to the environment is a transversal concern throughout the industry. For pharmaceutical and biomedical companies, green
chemistry is a principle to have in mind, particularly in their search for new substances or matrices to deliver drugs or solve problems of solubility, polymorphism,
toxicity, bioavailability, and pharmacokinetic. Currently, despite the investment on
research and development, it is increasingly difficult to find new molecules to substitute the “old” ones with enhanced therapeutic efficacy. Because of that, the
F. Santos · A. R. C. Duarte (*)
LAQV, REQUIMTE, Departamento de Química da Faculdade de Ciências e Tecnologia,
Universidade Nova de Lisboa, Caparica, Portugal
e-mail: aduarte@fct.unl.pt