101
Silva NHCS, Pinto RJB, Martins MA, Ferreira R, Correia I, Freire CSR, Marrucho IM (2018a)
Ionic liquids as promoters of fast lysozyme fibrillation. J Mol Liq 272:456–467. https://doi.
org/10.1016/j.molliq.2018.08.064
Silva NHCS, Vilela C, Pinto RJB, Martins MA, Marrucho IM, Freire CSR (2018b) Tuning lysozyme nanofibers dimensions using deep eutectic solvents for improved reinforcement ability.
Int J Biol Macromol 115:518–527. https://doi.org/10.1016/j.ijbiomac.2018.03.150
Silva JM, Silva E, Reis RL, Duarte ARC (2019) A closer look in the antimicrobial properties
of deep eutectic solvents based on fatty acids. Sustain Chem Pharm 14:100192. https://doi.
org/10.1016/j.scp.2019.100192
Sivapragasam M, Wilfred CD, Jaganathan JR, Krishnan S, Ghani WAWAK (2019) Choline-based
ionic liquids as media for the growth of Saccharomyces cerevisiae. PRO 7:471. https://doi.
org/10.3390/pr7070471
Stott PW, Williams AC, Barry BW (1998) Transdermal delivery from eutectic systems: enhanced
permeation of a model drug, ibuprofen. J Control Release 50:297–308. https://doi.org/10.1016/
S0168-3659(97)00153-3
Su E, Klibanov AM (2015) Low-transition-temperature mixtures (LTTMs) for dissolving proteins
and for drug formulation. Appl Biochem Biotechnol 177:753–758. https://doi.org/10.1007/
s12010-015-1777-x
Sut S, Faggian M, Baldan V, Poloniato G, Castagliuolo I, Grabnar I, Perissutti B, Brun P, Maggi
F, Voinovich D, Peron G, Dall’Acqua S (2017) Natural deep eutectic solvents (NADES) to
enhance Berberine absorption: an in vivo pharmacokinetic study. Molecules 22:E1921. https://
doi.org/10.3390/molecules22111921
Tang N, Zhong J, Yan W (2016) Solubilities of three flavonoids in different natural deep eutectic
solvents at T = (288.15 to 328.15) K. J Chem Eng Data 61:4203–4208. https://doi.org/10.1021/
acs.jced.6b00552
Tanner EEL, Ibsen KN, Mitragotri S (2018) Transdermal insulin delivery using choline-based ionic
liquids (CAGE). J Control Release 286:137–144. https://doi.org/10.1016/j.jconrel.2018.07.029
Tanner EEL, Curreri AM, JP B, Selig-Wober NC, Yang AB, Kendig C, Fluhr MP, Kim N,
Mitragotri S (2019) Design principles of ionic liquids for transdermal drug delivery. Adv Mater
e1901103:31. https://doi.org/10.1002/adma.201901103
Tarate B, Bansal AK (2015) Characterization of CoQ 10-lauric acid eutectic system. Thermochim
Acta 605:100–106. https://doi.org/10.1016/j.tca.2015.01.018
Tateishi-Karimata H, Sugimoto N (2014) Structure, stability and behaviour of nucleic acids in
ionic liquids. Nucleic Acids Res 42:8831–8844. https://doi.org/10.1093/nar/gku499
Tønnesen HH, Wikene KO (2016) Eutectic solvents and uses thereof. WO2016108083
Torregrosa-Crespo J, Marset X, Guillena G, Ramón DJ, María Martínez-Espinosa R (2020) New
guidelines for testing “Deep eutectic solvents” toxicity and their effects on the environment and
living beings. Sci Total Environ 704:135382. https://doi.org/10.1016/j.scitotenv.2019.135382
Vanda H, Dai Y, Wilson EG, Verpoorte R, Choi YH (2018) Green solvents from ionic liquids and
deep eutectic solvents to natural deep eutectic solvents. CR Chimie 21:628–638. https://doi.
org/10.1016/j.crci.2018.04.002
Wang J, Dong X, Yu Q, Baker SN, Li H, Larm NE, Baker GA, Chen L, Tan J, Chen M (2017)
Incorporation of antibacterial agent derived deep eutectic solvent into an active dental composite. Dent Mater 33:1445–1455. https://doi.org/10.1016/j.dental.2017.09.014
Wen Q, Chen JX, Tang YL, Wang J, Yang Z (2015) Assessing the toxicity and biodegradability of deep eutectic solvents. Chemosphere 132:63–69. https://doi.org/10.1016/j.
chemosphere.2015.02.061
Wikene KO, Bruzell E, Tønnesen HH (2015a) Characterization and antimicrobial phototoxicity of
curcumin dissolved in natural deep eutectic solvents. Eur J Pharm Sci 80:26–32. https://doi.
org/10.1016/j.ejps.2015.09.013
Wikene KO, Bruzell E, Tønnesen HH (2015b) Improved antibacterial phototoxicity of a neutral
porphyrin in natural deep eutectic solvents. J Photochem Photobiol B 148:188–196. https://doi.
org/10.1016/j.jphotobiol.2015.04.022
2 Deep Eutectic Solvents for Innovative Pharmaceutical Formulations
Silva NHCS, Pinto RJB, Martins MA, Ferreira R, Correia I, Freire CSR, Marrucho IM (2018a)
Ionic liquids as promoters of fast lysozyme fibrillation. J Mol Liq 272:456–467. https://doi.
org/10.1016/j.molliq.2018.08.064
Silva NHCS, Vilela C, Pinto RJB, Martins MA, Marrucho IM, Freire CSR (2018b) Tuning lysozyme nanofibers dimensions using deep eutectic solvents for improved reinforcement ability.
Int J Biol Macromol 115:518–527. https://doi.org/10.1016/j.ijbiomac.2018.03.150
Silva JM, Silva E, Reis RL, Duarte ARC (2019) A closer look in the antimicrobial properties
of deep eutectic solvents based on fatty acids. Sustain Chem Pharm 14:100192. https://doi.
org/10.1016/j.scp.2019.100192
Sivapragasam M, Wilfred CD, Jaganathan JR, Krishnan S, Ghani WAWAK (2019) Choline-based
ionic liquids as media for the growth of Saccharomyces cerevisiae. PRO 7:471. https://doi.
org/10.3390/pr7070471
Stott PW, Williams AC, Barry BW (1998) Transdermal delivery from eutectic systems: enhanced
permeation of a model drug, ibuprofen. J Control Release 50:297–308. https://doi.org/10.1016/
S0168-3659(97)00153-3
Su E, Klibanov AM (2015) Low-transition-temperature mixtures (LTTMs) for dissolving proteins
and for drug formulation. Appl Biochem Biotechnol 177:753–758. https://doi.org/10.1007/
s12010-015-1777-x
Sut S, Faggian M, Baldan V, Poloniato G, Castagliuolo I, Grabnar I, Perissutti B, Brun P, Maggi
F, Voinovich D, Peron G, Dall’Acqua S (2017) Natural deep eutectic solvents (NADES) to
enhance Berberine absorption: an in vivo pharmacokinetic study. Molecules 22:E1921. https://
doi.org/10.3390/molecules22111921
Tang N, Zhong J, Yan W (2016) Solubilities of three flavonoids in different natural deep eutectic
solvents at T = (288.15 to 328.15) K. J Chem Eng Data 61:4203–4208. https://doi.org/10.1021/
acs.jced.6b00552
Tanner EEL, Ibsen KN, Mitragotri S (2018) Transdermal insulin delivery using choline-based ionic
liquids (CAGE). J Control Release 286:137–144. https://doi.org/10.1016/j.jconrel.2018.07.029
Tanner EEL, Curreri AM, JP B, Selig-Wober NC, Yang AB, Kendig C, Fluhr MP, Kim N,
Mitragotri S (2019) Design principles of ionic liquids for transdermal drug delivery. Adv Mater
e1901103:31. https://doi.org/10.1002/adma.201901103
Tarate B, Bansal AK (2015) Characterization of CoQ 10-lauric acid eutectic system. Thermochim
Acta 605:100–106. https://doi.org/10.1016/j.tca.2015.01.018
Tateishi-Karimata H, Sugimoto N (2014) Structure, stability and behaviour of nucleic acids in
ionic liquids. Nucleic Acids Res 42:8831–8844. https://doi.org/10.1093/nar/gku499
Tønnesen HH, Wikene KO (2016) Eutectic solvents and uses thereof. WO2016108083
Torregrosa-Crespo J, Marset X, Guillena G, Ramón DJ, María Martínez-Espinosa R (2020) New
guidelines for testing “Deep eutectic solvents” toxicity and their effects on the environment and
living beings. Sci Total Environ 704:135382. https://doi.org/10.1016/j.scitotenv.2019.135382
Vanda H, Dai Y, Wilson EG, Verpoorte R, Choi YH (2018) Green solvents from ionic liquids and
deep eutectic solvents to natural deep eutectic solvents. CR Chimie 21:628–638. https://doi.
org/10.1016/j.crci.2018.04.002
Wang J, Dong X, Yu Q, Baker SN, Li H, Larm NE, Baker GA, Chen L, Tan J, Chen M (2017)
Incorporation of antibacterial agent derived deep eutectic solvent into an active dental composite. Dent Mater 33:1445–1455. https://doi.org/10.1016/j.dental.2017.09.014
Wen Q, Chen JX, Tang YL, Wang J, Yang Z (2015) Assessing the toxicity and biodegradability of deep eutectic solvents. Chemosphere 132:63–69. https://doi.org/10.1016/j.
chemosphere.2015.02.061
Wikene KO, Bruzell E, Tønnesen HH (2015a) Characterization and antimicrobial phototoxicity of
curcumin dissolved in natural deep eutectic solvents. Eur J Pharm Sci 80:26–32. https://doi.
org/10.1016/j.ejps.2015.09.013
Wikene KO, Bruzell E, Tønnesen HH (2015b) Improved antibacterial phototoxicity of a neutral
porphyrin in natural deep eutectic solvents. J Photochem Photobiol B 148:188–196. https://doi.
org/10.1016/j.jphotobiol.2015.04.022
2 Deep Eutectic Solvents for Innovative Pharmaceutical Formulations