90
Chen et al. have determined the pharmacokinetics and acute toxicity of salvianolic acid B after oral administration within a choline chloride:glycerol (1:2) deep
eutectic solvent (Chen et al. 2017). It was clear from the results that this solvent
promoted the absorption of the active compound, with a higher maximum plasma
concentration achieved early than from an aqueous solution, although the areas
under the curve and the mean retention time were similar for the two formulations.
The prolife of metabolites detected in the blood was also similar.
As a preliminary to its use as an oral formulation, Jeliński et al. tested the solubility in synthetic gastrointestinal medium of curcumin either added as an aqueous
solution or in natural deep eutectic solvents formed from choline chloride and
Fig. 2.7 Photomicrographs of hematoxylin and eosin-stained small intestine tissue sections (scale
bar: 200 μm, inserts are intestinal sections with scale bar of 50 μm.). Sections represent oral administration of neat CAGE, insulin-saline, or insulin-CAGE capsules after a single dose or after daily
dosing for 7 days of insulin, CAGE, or insulin-CAGE capsules. (Banerjee et al. 2018a, reprinted
with permission of Proceedings of the National Academy of Sciences)
C.-H. Nguyen et al.
Chen et al. have determined the pharmacokinetics and acute toxicity of salvianolic acid B after oral administration within a choline chloride:glycerol (1:2) deep
eutectic solvent (Chen et al. 2017). It was clear from the results that this solvent
promoted the absorption of the active compound, with a higher maximum plasma
concentration achieved early than from an aqueous solution, although the areas
under the curve and the mean retention time were similar for the two formulations.
The prolife of metabolites detected in the blood was also similar.
As a preliminary to its use as an oral formulation, Jeliński et al. tested the solubility in synthetic gastrointestinal medium of curcumin either added as an aqueous
solution or in natural deep eutectic solvents formed from choline chloride and
Fig. 2.7 Photomicrographs of hematoxylin and eosin-stained small intestine tissue sections (scale
bar: 200 μm, inserts are intestinal sections with scale bar of 50 μm.). Sections represent oral administration of neat CAGE, insulin-saline, or insulin-CAGE capsules after a single dose or after daily
dosing for 7 days of insulin, CAGE, or insulin-CAGE capsules. (Banerjee et al. 2018a, reprinted
with permission of Proceedings of the National Academy of Sciences)
C.-H. Nguyen et al.