339
Hui Y, Ma X, Hou X, Chen F, Yu J (2015) Silver nanoparticles-β-cyclodextrin-graphene nanocomposites based biosensor for guanine and adenine sensing. Ionics (Kiel) 21:1751–1759. https://
doi.org/10.1007/s11581-014-1343-5
Irie T, Uekama K (1997) Pharmaceutical applications of cyclodextrins. III. Toxicological issues
and safety evaluation. J Pharm Sci 86:147–162. https://doi.org/10.1021/js960213f
Jain SK, Gupta Y, Jain A, Bhola M (2007) Multivesicular liposomes bearing celecoxibβ- cyclodextrin complex for transdermal delivery. Drug Deliv 14:327–335. https://doi.
org/10.1080/10717540601098740
Jaiswal S, Bhattacharya K, McHale P, Duffy B (2015) Dual effects of β-cyclodextrin-stabilised
silver nanoparticles: enhanced biofilm inhibition and reduced cytotoxicity. J Mater Sci Mater
Med 26. https://doi.org/10.1007/s10856-014-5367-1
Ji T, Li S, Zhang Y, Lang J, Ding Y, Zhao X, Zhao R, Li Y, Shi J, Hao J, Zhao Y, Nie G (2016) An
MMP-2 responsive liposome integrating antifibrosis and chemotherapeutic cyclodextrin drugs
for enhanced drug perfusion and efficacy in pancreatic cancer. ACS Appl Mater Interfaces
8:3438–3445. https://doi.org/10.1021/acsami.5b11619
Kadari A, Gudem S, Kulhari H, Bhandi MM, Borkar RM, Kolapalli VRM, Sistla R (2017)
Enhanced oral bioavailability and anticancer efficacy of fisetin by encapsulating as inclusion
complex with HPβCD in polymeric nanoparticles. Drug Deliv 24:224–232. https://doi.org/1
0.1080/10717544.2016.1245366
Khalil SK, El-Feky GS, El-Banna ST, Khalil WA (2012) Preparation and evaluation of warfarinβ- cyclodextrin loaded chitosan nanoparticles for transdermal delivery. Carbohydr Polym
15:1244–1253. https://doi.org/10.1016/j.carbpol.2012.06.056
Krauland AH, Alonso MJ (2007) Chitosan/cyclodextrin nanoparticles as macromolecular drug
delivery system. Int J Pharm 340:134–142. https://doi.org/10.1016/j.ijpharm.2007.03.005
Kurkov SV, Loftsson T (2013) Cyclodextrins. Int J Pharm 30:167–180. https://doi.org/10.1016/j.
ijpharm.2012.06.055
Kwon TK, Kim JC (2010) In vitro skin permeation of mono olein nanoparticles containing
hydroxypropyl beta-cyclodextrin/minoxidil complex. Int J Pharm 392:268–273. https://doi.
org/10.1016/j.ijpharm.2010.03.04
Langie SAS, Knaapen AM, Houben JMJ, van Kempen FC, de Hoon JPJ, Gottschalk RWH,
Godschalk RWL, van Schooten FJ (2007) The role of glutathione in the regulation of nucleotide
excision repair during oxidative stress. Toxicol Lett 168:302–309. https://doi.org/10.1016/j.
toxlet.2006.10.027
Li R, Liu S, Zhao J, Otsuka H, Takahara A (2011) Preparation of superparamagnetic β-cyclodextrinfunctionalized composite nanoparticles with core-shell structures. Polym Bull 66:1125–1136.
https://doi.org/10.1007/s00289-010-0410-y
Lin C, Chen F, Ye T, Zhang L, Zhang W, Liu D, Xiong W, Yang X, Pan W (2014) A novel oral
delivery system consisting in “drug-in cyclodextrin-in nanostructured lipid carriers” for
poorly water-soluble drug: Vinpocetine. Int J Pharm 465:90–96. https://doi.org/10.1016/j.
ijpharm.2014.02.013
Liu J, Xu R, Kaifer AE (1998) In situ modification of the surface of gold colloidal particles.
Preparation of cyclodextrin-based rotaxanes supported on gold nanospheres. Langmuir
14:7337–7339. https://doi.org/10.1021/la981385q
Loftsson T, Duchêne D (2007) Cyclodextrins and their pharmaceutical applications. Int J Pharm
329:1–11. https://doi.org/10.1016/j.ijpharm.2006.10.044
Luo Z, Cai K, Hu Y, Li J, Ding X, Zhang B, Xu D, Yang W, Liu P (2012) Redox-responsive
molecular nanoreservoirs for controlled intracellular anticancer drug delivery based on magnetic nanoparticles. Adv Mater 24:431–435. https://doi.org/10.1002/adma.201103458
Luppi B, Bigucci F, Corace G, Delucca A, Cerchiara T, Sorrenti M, Catenacci L, Di Pietra
AM, Zecchi V (2011) Albumin nanoparticles carrying cyclodextrins for nasal delivery of
the anti-Alzheimer drug tacrine. Eur J Pharm Sci 44:559–565. https://doi.org/10.1016/j.
ejps.2011.10.002
7 Role of Cyclodextrins in Nanoparticle-Based Systems for Drug Delivery
Hui Y, Ma X, Hou X, Chen F, Yu J (2015) Silver nanoparticles-β-cyclodextrin-graphene nanocomposites based biosensor for guanine and adenine sensing. Ionics (Kiel) 21:1751–1759. https://
doi.org/10.1007/s11581-014-1343-5
Irie T, Uekama K (1997) Pharmaceutical applications of cyclodextrins. III. Toxicological issues
and safety evaluation. J Pharm Sci 86:147–162. https://doi.org/10.1021/js960213f
Jain SK, Gupta Y, Jain A, Bhola M (2007) Multivesicular liposomes bearing celecoxibβ- cyclodextrin complex for transdermal delivery. Drug Deliv 14:327–335. https://doi.
org/10.1080/10717540601098740
Jaiswal S, Bhattacharya K, McHale P, Duffy B (2015) Dual effects of β-cyclodextrin-stabilised
silver nanoparticles: enhanced biofilm inhibition and reduced cytotoxicity. J Mater Sci Mater
Med 26. https://doi.org/10.1007/s10856-014-5367-1
Ji T, Li S, Zhang Y, Lang J, Ding Y, Zhao X, Zhao R, Li Y, Shi J, Hao J, Zhao Y, Nie G (2016) An
MMP-2 responsive liposome integrating antifibrosis and chemotherapeutic cyclodextrin drugs
for enhanced drug perfusion and efficacy in pancreatic cancer. ACS Appl Mater Interfaces
8:3438–3445. https://doi.org/10.1021/acsami.5b11619
Kadari A, Gudem S, Kulhari H, Bhandi MM, Borkar RM, Kolapalli VRM, Sistla R (2017)
Enhanced oral bioavailability and anticancer efficacy of fisetin by encapsulating as inclusion
complex with HPβCD in polymeric nanoparticles. Drug Deliv 24:224–232. https://doi.org/1
0.1080/10717544.2016.1245366
Khalil SK, El-Feky GS, El-Banna ST, Khalil WA (2012) Preparation and evaluation of warfarinβ- cyclodextrin loaded chitosan nanoparticles for transdermal delivery. Carbohydr Polym
15:1244–1253. https://doi.org/10.1016/j.carbpol.2012.06.056
Krauland AH, Alonso MJ (2007) Chitosan/cyclodextrin nanoparticles as macromolecular drug
delivery system. Int J Pharm 340:134–142. https://doi.org/10.1016/j.ijpharm.2007.03.005
Kurkov SV, Loftsson T (2013) Cyclodextrins. Int J Pharm 30:167–180. https://doi.org/10.1016/j.
ijpharm.2012.06.055
Kwon TK, Kim JC (2010) In vitro skin permeation of mono olein nanoparticles containing
hydroxypropyl beta-cyclodextrin/minoxidil complex. Int J Pharm 392:268–273. https://doi.
org/10.1016/j.ijpharm.2010.03.04
Langie SAS, Knaapen AM, Houben JMJ, van Kempen FC, de Hoon JPJ, Gottschalk RWH,
Godschalk RWL, van Schooten FJ (2007) The role of glutathione in the regulation of nucleotide
excision repair during oxidative stress. Toxicol Lett 168:302–309. https://doi.org/10.1016/j.
toxlet.2006.10.027
Li R, Liu S, Zhao J, Otsuka H, Takahara A (2011) Preparation of superparamagnetic β-cyclodextrinfunctionalized composite nanoparticles with core-shell structures. Polym Bull 66:1125–1136.
https://doi.org/10.1007/s00289-010-0410-y
Lin C, Chen F, Ye T, Zhang L, Zhang W, Liu D, Xiong W, Yang X, Pan W (2014) A novel oral
delivery system consisting in “drug-in cyclodextrin-in nanostructured lipid carriers” for
poorly water-soluble drug: Vinpocetine. Int J Pharm 465:90–96. https://doi.org/10.1016/j.
ijpharm.2014.02.013
Liu J, Xu R, Kaifer AE (1998) In situ modification of the surface of gold colloidal particles.
Preparation of cyclodextrin-based rotaxanes supported on gold nanospheres. Langmuir
14:7337–7339. https://doi.org/10.1021/la981385q
Loftsson T, Duchêne D (2007) Cyclodextrins and their pharmaceutical applications. Int J Pharm
329:1–11. https://doi.org/10.1016/j.ijpharm.2006.10.044
Luo Z, Cai K, Hu Y, Li J, Ding X, Zhang B, Xu D, Yang W, Liu P (2012) Redox-responsive
molecular nanoreservoirs for controlled intracellular anticancer drug delivery based on magnetic nanoparticles. Adv Mater 24:431–435. https://doi.org/10.1002/adma.201103458
Luppi B, Bigucci F, Corace G, Delucca A, Cerchiara T, Sorrenti M, Catenacci L, Di Pietra
AM, Zecchi V (2011) Albumin nanoparticles carrying cyclodextrins for nasal delivery of
the anti-Alzheimer drug tacrine. Eur J Pharm Sci 44:559–565. https://doi.org/10.1016/j.
ejps.2011.10.002
7 Role of Cyclodextrins in Nanoparticle-Based Systems for Drug Delivery