281
© The Editor(s) (if applicable) and The Author(s), under exclusive license to
Springer Nature Switzerland AG 2020
G. Crini et al. (eds.), The History of Cyclodextrins, Environmental Chemistry
for a Sustainable World 52, https://doi.org/10.1007/978-3-030-49308-0_6
Chapter 6
Cyclodextrin-Based Polymers for Food
and Pharmaceutical Applications:
A Historical Review
Max Petitjean, Iñigo X. García-Zubiri, and José Ramón Isasi
Contents
6.1 Introduction
282
6.2 Cyclodextrin Polymers
283
6.2.1 Historical Perspective of Cyclodextrin Polymers
283
6.2.2 Covalent and Supramolecular Architectures
285
6.3 Applications in the Food and Pharmaceutical Areas
290
6.3.1 Cyclodextrin Polymers in Food Science
290
6.3.2 Cyclodextrin Polymers in Drug Delivery
292
6.4 Conclusion
296
References
297
Abstract The encapsulation capabilities of cyclodextrins and the controlled release
of guest molecules can be modulated with the aid of the additional functionality of
a polymeric macrostructure. In addition, the covalent attachment of cyclodextrin
moieties to a pre-existing material is intended to immobilize them, as in the case of
medical devices or packaging applications. The first references dealing with the
potential use of cyclodextrin polymers as macromolecular carriers date back to the
1980s. Since then, they have been incorporated into many constructions, such as
hydrogels, nanosponges, dendrimers, interpenetrating networks, molecular
imprinted polymers, and other smart biomaterials.
The present chapter discusses, from a historical perspective, the evolution of the
synthesis procedures to prepare covalently linked cyclodextrins, either by grafting
or cross-linking mechanisms. Then, their applications in the food and pharmaceutical sectors are presented. Debittering of juices and retention of flavors were the first
M. Petitjean · J. R. Isasi (*)
Departamento de Química, Facultad de Ciencias, Universidad de Navarra, Pamplona, Spain
e-mail: mpetitjean@alumni.unav.es; jrisasi@unav.es
I. X. García-Zubiri
Magnesitas Navarras, Zubiri, Navarra, Spain
e-mail: inigo.garcia@magnesitasnavarras.es
© The Editor(s) (if applicable) and The Author(s), under exclusive license to
Springer Nature Switzerland AG 2020
G. Crini et al. (eds.), The History of Cyclodextrins, Environmental Chemistry
for a Sustainable World 52, https://doi.org/10.1007/978-3-030-49308-0_6
Chapter 6
Cyclodextrin-Based Polymers for Food
and Pharmaceutical Applications:
A Historical Review
Max Petitjean, Iñigo X. García-Zubiri, and José Ramón Isasi
Contents
6.1 Introduction
282
6.2 Cyclodextrin Polymers
283
6.2.1 Historical Perspective of Cyclodextrin Polymers
283
6.2.2 Covalent and Supramolecular Architectures
285
6.3 Applications in the Food and Pharmaceutical Areas
290
6.3.1 Cyclodextrin Polymers in Food Science
290
6.3.2 Cyclodextrin Polymers in Drug Delivery
292
6.4 Conclusion
296
References
297
Abstract The encapsulation capabilities of cyclodextrins and the controlled release
of guest molecules can be modulated with the aid of the additional functionality of
a polymeric macrostructure. In addition, the covalent attachment of cyclodextrin
moieties to a pre-existing material is intended to immobilize them, as in the case of
medical devices or packaging applications. The first references dealing with the
potential use of cyclodextrin polymers as macromolecular carriers date back to the
1980s. Since then, they have been incorporated into many constructions, such as
hydrogels, nanosponges, dendrimers, interpenetrating networks, molecular
imprinted polymers, and other smart biomaterials.
The present chapter discusses, from a historical perspective, the evolution of the
synthesis procedures to prepare covalently linked cyclodextrins, either by grafting
or cross-linking mechanisms. Then, their applications in the food and pharmaceutical sectors are presented. Debittering of juices and retention of flavors were the first
M. Petitjean · J. R. Isasi (*)
Departamento de Química, Facultad de Ciencias, Universidad de Navarra, Pamplona, Spain
e-mail: mpetitjean@alumni.unav.es; jrisasi@unav.es
I. X. García-Zubiri
Magnesitas Navarras, Zubiri, Navarra, Spain
e-mail: inigo.garcia@magnesitasnavarras.es