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49:9699–9701
Fernandez Rivas D, Cintas P, Gardeniers HJGE (2012a) Merging microfluidics and sonochemistry:
towards greener and more efficient micro-sono-reactors. Chem Commun 48:10935–10947
Fernandez Rivas D, Ashokkumar M, Leong T, Yasui K, Tuziuti T, Kentish S et al (2012b) Sonoluminescence and sonochemiluminescence from a microreactor. Ultrason Sonochem 19:1252–1259
Fernandez Rivas D, Verhaagen B, Seddon JRT, Zijlstra AG, Jiang LM, van der Sluis LWM et al
(2012c) Localized removal of layers of metal, polymer, or biomaterial by ultrasound cavitation
bubbles. Biomicrofluidics 6:034114
Fernandez Rivas D, Stricker L, Zijlstra AG, Gardeniers HJGE, Lohse D, Prosperetti A (2013a)
Ultrasound artificially nucleated bubbles and their sonochemical radical production. Ultrason
Sonochem 20:510–524
Fernandez Rivas D, Betjes J, Verhaagen B, Bouwhuis W, Bor TC, Lohse D, Gardeniers HJGE
(2013b) Erosion evolution in mono-crystalline silicon surfaces caused by acoustic cavitation
bubbles. J Appl Phys 113:064902
Fitzpatrick DE, Battilochio C, Ley SV (2016) Enabling technologies for the future of chemical
synthesis. ACS Cent Sci 2:131–138
Friend J, Yeo LY (2011) Microscale acoustofluidics: microfluidics driven via acoustics and ultrasonics. Rev Mod Phys 83(2):647
Günther A, Jensen KF (2006) Multiphase microfluidics: from flow characteristics to chemical and
materials synthesis. Lab Chip 6:1487–1503
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Hughes DL (2018) Applications of flow chemistry in drug development: highlights of recent patent
literature. Org Process Res Dev. https://doi.org/10.1021/acs.oprd.7b00363 (in press)
Ingham RJ, Battilochio C, Fitzpatrick DE, Sliwinski E, Hawkins JM, Ley SV (2015) A systems
approach towards intelligent and self-controlling platform for integrated continuous reaction
sequences. Angew Chem Int Ed 54:144–148
Jensen KF (2017) Flow chemistry-microreaction technology comes of age. AIChE J 63:858–869
Kaminski TS, Garstecki P (2017) Controlled droplet microfluidic systems for multistep chemical
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Kashid MN, Gerlach I, Goetz S, Franzke J, Acker JF, Platte F, Agar DW, Turek S (2005) Internal
circulation within the liquid slugs of a liquid–liquid slug-flow capillary microreactor. Ind Eng
Chem Res 44(14):5003–5010
Kuhn S, Noël T, Gu L, Heider PL, Jensen KF (2011) A Teflon microreactor with integrated piezoelectric actuator to handle solid forming reactions. Lab Chip 11:2488–2492
Kulkarni K, Friend J, Yeo L, Perlmutter P (2009) Surface acoustic waves as an emerging source for
drop scale synthetic chemistry. Lab Chip 9:754–755
Kulkarni K, Ramarathinam SH, Friend J, Yeo L, Purcell AW, Perlmutter P (2010) Rapid microscale
in-gel processing and digestion of proteins using surface acoustic waves. Lab Chip 10:1518–1520
Lee YH, Li PH (2017) Using resonant ultrasound field-incorporated dynamic photobioreactor system to enhance medium replacement process for concentrated microalgae cultivation in continuous mode. Chem Eng Res Des 118:112–120
Lenshof A, Magnusson C, Laurell T (2012) Acoustofluidics 8: applications of acoustophoresis in
continuous flow microsystems. Lab Chip 12:1210–1223
Leonelli C, Mason TJ (2010) Microwave and ultrasonic processing: now a realistic option for
industry. Chem Eng Process 49:885–900
Lin H, Dai C, Jamison TF, Jensen KF (2017) A rapid total synthesis of ciprofloxacin hydrochloride
in continuous flow. Angew Chem Int Ed 56:8870–8873
Lohse D (2005) Sonoluminescence: cavitation hots up. Nature 434:33–34
Nagy KD, Shen B, Jamison TF, Jensen KF (2012) Mixing and dispersion in small-scale flow systems.
Org Process Res Dev 16:976–981
85
Fernandez Rivas D, Prosperetti A, Zijlstra AG, Lohse D, Gardeniers HJGE (2010) Efficient sonochemistry through microbubbles generated with micromachined surfaces. Angew Chem Int Ed
49:9699–9701
Fernandez Rivas D, Cintas P, Gardeniers HJGE (2012a) Merging microfluidics and sonochemistry:
towards greener and more efficient micro-sono-reactors. Chem Commun 48:10935–10947
Fernandez Rivas D, Ashokkumar M, Leong T, Yasui K, Tuziuti T, Kentish S et al (2012b) Sonoluminescence and sonochemiluminescence from a microreactor. Ultrason Sonochem 19:1252–1259
Fernandez Rivas D, Verhaagen B, Seddon JRT, Zijlstra AG, Jiang LM, van der Sluis LWM et al
(2012c) Localized removal of layers of metal, polymer, or biomaterial by ultrasound cavitation
bubbles. Biomicrofluidics 6:034114
Fernandez Rivas D, Stricker L, Zijlstra AG, Gardeniers HJGE, Lohse D, Prosperetti A (2013a)
Ultrasound artificially nucleated bubbles and their sonochemical radical production. Ultrason
Sonochem 20:510–524
Fernandez Rivas D, Betjes J, Verhaagen B, Bouwhuis W, Bor TC, Lohse D, Gardeniers HJGE
(2013b) Erosion evolution in mono-crystalline silicon surfaces caused by acoustic cavitation
bubbles. J Appl Phys 113:064902
Fitzpatrick DE, Battilochio C, Ley SV (2016) Enabling technologies for the future of chemical
synthesis. ACS Cent Sci 2:131–138
Friend J, Yeo LY (2011) Microscale acoustofluidics: microfluidics driven via acoustics and ultrasonics. Rev Mod Phys 83(2):647
Günther A, Jensen KF (2006) Multiphase microfluidics: from flow characteristics to chemical and
materials synthesis. Lab Chip 6:1487–1503
Gutmann B, Cantillo D, Kappe CO (2015) Continuous flow technology-a tool for the safe manufacturing of active pharmaceutical ingredients. Angew Chem Int Ed 54:6688–6728
Hughes DL (2018) Applications of flow chemistry in drug development: highlights of recent patent
literature. Org Process Res Dev. https://doi.org/10.1021/acs.oprd.7b00363 (in press)
Ingham RJ, Battilochio C, Fitzpatrick DE, Sliwinski E, Hawkins JM, Ley SV (2015) A systems
approach towards intelligent and self-controlling platform for integrated continuous reaction
sequences. Angew Chem Int Ed 54:144–148
Jensen KF (2017) Flow chemistry-microreaction technology comes of age. AIChE J 63:858–869
Kaminski TS, Garstecki P (2017) Controlled droplet microfluidic systems for multistep chemical
and biological assays. Chem Soc Rev 46:6210–6226
Kashid MN, Gerlach I, Goetz S, Franzke J, Acker JF, Platte F, Agar DW, Turek S (2005) Internal
circulation within the liquid slugs of a liquid–liquid slug-flow capillary microreactor. Ind Eng
Chem Res 44(14):5003–5010
Kuhn S, Noël T, Gu L, Heider PL, Jensen KF (2011) A Teflon microreactor with integrated piezoelectric actuator to handle solid forming reactions. Lab Chip 11:2488–2492
Kulkarni K, Friend J, Yeo L, Perlmutter P (2009) Surface acoustic waves as an emerging source for
drop scale synthetic chemistry. Lab Chip 9:754–755
Kulkarni K, Ramarathinam SH, Friend J, Yeo L, Purcell AW, Perlmutter P (2010) Rapid microscale
in-gel processing and digestion of proteins using surface acoustic waves. Lab Chip 10:1518–1520
Lee YH, Li PH (2017) Using resonant ultrasound field-incorporated dynamic photobioreactor system to enhance medium replacement process for concentrated microalgae cultivation in continuous mode. Chem Eng Res Des 118:112–120
Lenshof A, Magnusson C, Laurell T (2012) Acoustofluidics 8: applications of acoustophoresis in
continuous flow microsystems. Lab Chip 12:1210–1223
Leonelli C, Mason TJ (2010) Microwave and ultrasonic processing: now a realistic option for
industry. Chem Eng Process 49:885–900
Lin H, Dai C, Jamison TF, Jensen KF (2017) A rapid total synthesis of ciprofloxacin hydrochloride
in continuous flow. Angew Chem Int Ed 56:8870–8873
Lohse D (2005) Sonoluminescence: cavitation hots up. Nature 434:33–34
Nagy KD, Shen B, Jamison TF, Jensen KF (2012) Mixing and dispersion in small-scale flow systems.
Org Process Res Dev 16:976–981