170. Li J, Chi Z, Wang X, Peng Y, Chi Z (2009) The selection of alkaline protease-producing yeasts
from marine environments and evaluation of their bioactive peptide production. Chinese J
Oceanol Limnol 27:753–761
171. Kim W, Choi K, Kim Y, Park H, Choi J, Lee Y, Oh H, Kwon I, Lee S (1996) Purification and
characterization of a fibrinolytic enzyme produced from Bacillus sp. strain CK 11-4 screened
from Chungkook-Jang. Appl Environ Microbiol 62:2482–2488
172. Mukherjee AK, Rai SK (2011) A statistical approach for the enhanced production of alkaline
protease showing fibrinolytic activity from a newly isolated gram-negative Bacillus sp. strain
AS-S20-I. N Biotechnol 28:182–189
173. Simkhada JR, Mander P, Cho SS, You JC (2010) A novel fibrinolytic protease from Streptomyces sp. CS684. Process Biochem 45:88–93
174. Kudrya VA, Simonenko IA (1994) Alkaline serine proteinase and lectin isolation from the
culture fluid of Bacillus subtilis. Appl Microbiol Biotechnol 41:505–509
175. Davidenko T, Chuenko AV, Kovalenko VN (1997) Immobilized elastoterase. Pharm Chem J
31:396–398
176. Mamo G, Mattiasson B (2016) Alkaliphilic microorganisms in biotechnology. In: Pabulo HR
(ed) Biotechnology of extremophiles. Springer, Cham, pp 243–272
177. Fior Markets (2019) Global carotenoids market is expected to reach USD 3.59 billion by 2025.
https://www.globenewswire.com/news-release/2019/10/15/1929461/0/en/Global-Caroten
oids-Market-is-expected-to-reach-USD-3-59-billion-by-2025-Fior-Markets.html. Accessed
12 Feb 2020
178. Lee PC, Schmidt-Dannert C (2002) Metabolic engineering towards biotechnological production of carotenoids in microorganisms. Appl Microbiol Biotechnol 60:1–11
179. Mata-Gómez LC, Montañez JC, Méndez-Zavala A, Aguilar CN (2014) Biotechnological
production of carotenoids by yeasts: an overview. Microb Cell Fact 13:12
180. Miyashita K (2009) Function of marine carotenoids. Forum Nutr 61:136–146
181. Palozza P, Torelli C, Boninsegna A, Simone R, Catalano A, Mele MC, Picci N (2009) Growthinhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer
cells. Cancer Lett 283:108–117
182. Jyonouchi H, Sun S, Gross M (1995) Effect of carotenoids on in vitro immunoglobulin
production by human peripheral blood mononuclear cells: Astaxanthin, a carotenoid without
vitamin A activity, enhances in vitro immunoglobulin production in response to a T-dependent
stimulant and antigen. Nutr Cancer 23:171–183
183. Osanjo GO, Muthike EW, Tsuma L, Okoth MW, Bulimo WD, Lünsdorf H et al (2009) A salt
Lake extremophile, Paracoccus bogoriensis sp. nov., efficiently produces xanthophyll carotenoids. Afr J Microbiol Res 3:426–433
184. Khalikova E, Somersalo S, Korpela T (2019) Metabolites produced by alkaliphiles with
potential biotechnological applications. Adv Biochem Eng Biotechnol. https://doi.org/10.
1007/10_2019_96
185. Sarethy IP, Saxena Y, Kapoor A, Sharma M, Sharma SK, Gupta V, Gupta S (2011)
Alkaliphilic bacteria: applications in industrial biotechnology. J Ind Microbiol Biotechnol
38:769–790
186. Asao M, Takaichi S, Madigan MT (2012) Amino acid-assimilating phototrophic heliobacteria
from soda lake environments: Heliorestis acidaminivorans sp. nov. and ‘Candidatus
Heliomonas lunata’. Extremophiles 16:585–595
187. Drechsel H, Jung G (1998) Peptide siderophores. J Pept Sci 4:147–181
188. Melack JM, Kilham P (1974) Photosynthetic rates of phytoplankton in East African alkaline,
saline lakes. Limnol Oceanogr 19:743–755
189. McMillan DGG, Velasquez I, Nunn BL, Goodlett DR, Hunter KA, Lamont I, Sander SG,
Cook GM (2010) Acquisition of iron by alkaliphilic Bacillus species. Appl Environ Microbiol
76:6955–6961
Alkaliphiles: The Versatile Tools in Biotechnology
45
from marine environments and evaluation of their bioactive peptide production. Chinese J
Oceanol Limnol 27:753–761
171. Kim W, Choi K, Kim Y, Park H, Choi J, Lee Y, Oh H, Kwon I, Lee S (1996) Purification and
characterization of a fibrinolytic enzyme produced from Bacillus sp. strain CK 11-4 screened
from Chungkook-Jang. Appl Environ Microbiol 62:2482–2488
172. Mukherjee AK, Rai SK (2011) A statistical approach for the enhanced production of alkaline
protease showing fibrinolytic activity from a newly isolated gram-negative Bacillus sp. strain
AS-S20-I. N Biotechnol 28:182–189
173. Simkhada JR, Mander P, Cho SS, You JC (2010) A novel fibrinolytic protease from Streptomyces sp. CS684. Process Biochem 45:88–93
174. Kudrya VA, Simonenko IA (1994) Alkaline serine proteinase and lectin isolation from the
culture fluid of Bacillus subtilis. Appl Microbiol Biotechnol 41:505–509
175. Davidenko T, Chuenko AV, Kovalenko VN (1997) Immobilized elastoterase. Pharm Chem J
31:396–398
176. Mamo G, Mattiasson B (2016) Alkaliphilic microorganisms in biotechnology. In: Pabulo HR
(ed) Biotechnology of extremophiles. Springer, Cham, pp 243–272
177. Fior Markets (2019) Global carotenoids market is expected to reach USD 3.59 billion by 2025.
https://www.globenewswire.com/news-release/2019/10/15/1929461/0/en/Global-Caroten
oids-Market-is-expected-to-reach-USD-3-59-billion-by-2025-Fior-Markets.html. Accessed
12 Feb 2020
178. Lee PC, Schmidt-Dannert C (2002) Metabolic engineering towards biotechnological production of carotenoids in microorganisms. Appl Microbiol Biotechnol 60:1–11
179. Mata-Gómez LC, Montañez JC, Méndez-Zavala A, Aguilar CN (2014) Biotechnological
production of carotenoids by yeasts: an overview. Microb Cell Fact 13:12
180. Miyashita K (2009) Function of marine carotenoids. Forum Nutr 61:136–146
181. Palozza P, Torelli C, Boninsegna A, Simone R, Catalano A, Mele MC, Picci N (2009) Growthinhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer
cells. Cancer Lett 283:108–117
182. Jyonouchi H, Sun S, Gross M (1995) Effect of carotenoids on in vitro immunoglobulin
production by human peripheral blood mononuclear cells: Astaxanthin, a carotenoid without
vitamin A activity, enhances in vitro immunoglobulin production in response to a T-dependent
stimulant and antigen. Nutr Cancer 23:171–183
183. Osanjo GO, Muthike EW, Tsuma L, Okoth MW, Bulimo WD, Lünsdorf H et al (2009) A salt
Lake extremophile, Paracoccus bogoriensis sp. nov., efficiently produces xanthophyll carotenoids. Afr J Microbiol Res 3:426–433
184. Khalikova E, Somersalo S, Korpela T (2019) Metabolites produced by alkaliphiles with
potential biotechnological applications. Adv Biochem Eng Biotechnol. https://doi.org/10.
1007/10_2019_96
185. Sarethy IP, Saxena Y, Kapoor A, Sharma M, Sharma SK, Gupta V, Gupta S (2011)
Alkaliphilic bacteria: applications in industrial biotechnology. J Ind Microbiol Biotechnol
38:769–790
186. Asao M, Takaichi S, Madigan MT (2012) Amino acid-assimilating phototrophic heliobacteria
from soda lake environments: Heliorestis acidaminivorans sp. nov. and ‘Candidatus
Heliomonas lunata’. Extremophiles 16:585–595
187. Drechsel H, Jung G (1998) Peptide siderophores. J Pept Sci 4:147–181
188. Melack JM, Kilham P (1974) Photosynthetic rates of phytoplankton in East African alkaline,
saline lakes. Limnol Oceanogr 19:743–755
189. McMillan DGG, Velasquez I, Nunn BL, Goodlett DR, Hunter KA, Lamont I, Sander SG,
Cook GM (2010) Acquisition of iron by alkaliphilic Bacillus species. Appl Environ Microbiol
76:6955–6961
Alkaliphiles: The Versatile Tools in Biotechnology
45