112. Souagui Y, Tritsch D, Grosdemange-Billiard C, Kecha M (2015) Optimization of antifungal
production by an alkaliphilic and halotolerant actinomycete, Streptomyces sp. SY-BS5, using
response surface methodology. J Mycol Med 25(2):108–115. https://doi.org/10.1016/j.
mycmed.2014.12.004
113. Chun JY, Ryu IH, Park JS, Lee KS (2002) Anticaries activity of antimicrobial material from
Bacillus alkalophilshaggy JY-827. J Microbiol Biotechnol 12:18–24
114. Dieter A, Hamm A, Fiedler HP, Goodfellow M, Müller WEG, Brun R, Beil W, Bringmann G
(2003) Pyrocoll, an antibiotic, antiparasitic and antitumor compound produced by a novel
alkaliphilic Streptomyces strain. J Antibiot 56:639–646. https://doi.org/10.7164/antibiotics.
56.639
115. Fiedler HP, Goodfellow M (2004) Alkaliphilic streptomycetes as a source of novel secondary
metabolites. Microbiol Aust 25:27–29
116. Lawton EM, Cotter PD, Hill C, Ross RP (2007) Identification of a novel two-peptide
lantibiotic, haloduracin, produced by the alkaliphile Bacillus halodurans C-125. FEMS
Microbiol Lett 267:64–71. https://doi.org/10.1111/j.1574-6968.2006.00539.x
117. Danesh A, Mamo G, Mattiasson B (2011) Production of haloduracin by Bacillus halodurans
using solid-state fermentation. Biotechnol Lett 33:1339–1344
118. Ali MI, Ahmad MS, Hozzein WN (2009) WA52 – A Macrolide antibiotic produced by
alkalophile Nocardiopsis Dassonvillei WA52. Aust J Basic Appl Sci 3:607–616
119. Sanghvi GV, Ghevariya D, Gosai S, Langa R, Dhaduk N, Kunjadia PD, Vaishnav DJ, Dave
GS (2014) Isolation and partial purification of erythromycin from alkaliphilic Streptomyces
werraensis isolated from Rajkot, India. Biotechnol Rep 1–2:2–7
120. Li YQ, Li MG, Li W, Zhao JY, Ding ZG, Cui XL, Wen ML (2007) Griseusin D, a
new pyranonaphthoquinone derivative from a alkaphilic Nocardiopsis sp. J Antibiot
60(12):757–761
121. Ding ZG, Zhao JY, Li MG, Huang R, Li QM, Cui XL, Zhu HJ, Wen ML (2012) Griseusins F
and G, spironaphthoquinones from a tin mine tailings-derived alkalophilic Nocardiopsis
species. J Nat Prod 75:1994–1998
122. Ding ZG, Li MG, Zhao JY, Ren J, Huang R, Xie MJ, Cui XL, Zhu HJ, Wen ML (2010)
Naphthospironone A: an unprecedented and highly functionalized polycyclic metabolite from
an alkaline mine waste extremophile. Chem Eur J 16:3902–3905. https://doi.org/10.1002/
chem.200903198
123. Bisht GS, Bharti A, Kumar V, Gusain O (2013) Isolation, purification and partial characterization of an antifungal agent produced by salt-tolerant alkaliphilic Streptomyces violascens
IN2-10. Proc Natl Acad Sci India Sect B Biol Sci 83:109–117. https://doi.org/10.1007/
s40011-012-0086-1
124. Wang Z, Fu P, Liu P, Wang P, Hou J, Li W, Zhu W (2013) New pyran-2-ones from
alkalophilic actinomycete, Nocardiopsis alkaliphila sp. Nov. YIM-80379. Chem Biodivers
10:281–287. https://doi.org/10.1002/cbdv.201200086
125. Helaly SE, Goodfellow M, Zinecker H, Imhoff JF, Süssmuth RD, Fiedler HP (2013)
Warkmycin, a novel angucycline antibiotic produced by Streptomyces sp. Acta 2930.
J Antibiot (Tokyo) 66:669–674. https://www.nature.com/articles/ja20137
126. Jenifer A, Remya R, Velmurugan S, Michaelbabu M, Citarasu T (2018) Streptomyces
castaneoglobisporus AJ9, a haloalkaliphilic actinomycetes isolated from solar salt works in
southern India and its pharmacological properties. Indian J Mar Sci 47:475–488
127. Jonczyk E, Klak M, Miedzybrodzki R (2011) The influence of external factors on bacteriophages – a review. Folia Microbiol (Praha) 56:191–200
Metabolites Produced by Alkaliphiles with Potential Biotechnological. . .
193
production by an alkaliphilic and halotolerant actinomycete, Streptomyces sp. SY-BS5, using
response surface methodology. J Mycol Med 25(2):108–115. https://doi.org/10.1016/j.
mycmed.2014.12.004
113. Chun JY, Ryu IH, Park JS, Lee KS (2002) Anticaries activity of antimicrobial material from
Bacillus alkalophilshaggy JY-827. J Microbiol Biotechnol 12:18–24
114. Dieter A, Hamm A, Fiedler HP, Goodfellow M, Müller WEG, Brun R, Beil W, Bringmann G
(2003) Pyrocoll, an antibiotic, antiparasitic and antitumor compound produced by a novel
alkaliphilic Streptomyces strain. J Antibiot 56:639–646. https://doi.org/10.7164/antibiotics.
56.639
115. Fiedler HP, Goodfellow M (2004) Alkaliphilic streptomycetes as a source of novel secondary
metabolites. Microbiol Aust 25:27–29
116. Lawton EM, Cotter PD, Hill C, Ross RP (2007) Identification of a novel two-peptide
lantibiotic, haloduracin, produced by the alkaliphile Bacillus halodurans C-125. FEMS
Microbiol Lett 267:64–71. https://doi.org/10.1111/j.1574-6968.2006.00539.x
117. Danesh A, Mamo G, Mattiasson B (2011) Production of haloduracin by Bacillus halodurans
using solid-state fermentation. Biotechnol Lett 33:1339–1344
118. Ali MI, Ahmad MS, Hozzein WN (2009) WA52 – A Macrolide antibiotic produced by
alkalophile Nocardiopsis Dassonvillei WA52. Aust J Basic Appl Sci 3:607–616
119. Sanghvi GV, Ghevariya D, Gosai S, Langa R, Dhaduk N, Kunjadia PD, Vaishnav DJ, Dave
GS (2014) Isolation and partial purification of erythromycin from alkaliphilic Streptomyces
werraensis isolated from Rajkot, India. Biotechnol Rep 1–2:2–7
120. Li YQ, Li MG, Li W, Zhao JY, Ding ZG, Cui XL, Wen ML (2007) Griseusin D, a
new pyranonaphthoquinone derivative from a alkaphilic Nocardiopsis sp. J Antibiot
60(12):757–761
121. Ding ZG, Zhao JY, Li MG, Huang R, Li QM, Cui XL, Zhu HJ, Wen ML (2012) Griseusins F
and G, spironaphthoquinones from a tin mine tailings-derived alkalophilic Nocardiopsis
species. J Nat Prod 75:1994–1998
122. Ding ZG, Li MG, Zhao JY, Ren J, Huang R, Xie MJ, Cui XL, Zhu HJ, Wen ML (2010)
Naphthospironone A: an unprecedented and highly functionalized polycyclic metabolite from
an alkaline mine waste extremophile. Chem Eur J 16:3902–3905. https://doi.org/10.1002/
chem.200903198
123. Bisht GS, Bharti A, Kumar V, Gusain O (2013) Isolation, purification and partial characterization of an antifungal agent produced by salt-tolerant alkaliphilic Streptomyces violascens
IN2-10. Proc Natl Acad Sci India Sect B Biol Sci 83:109–117. https://doi.org/10.1007/
s40011-012-0086-1
124. Wang Z, Fu P, Liu P, Wang P, Hou J, Li W, Zhu W (2013) New pyran-2-ones from
alkalophilic actinomycete, Nocardiopsis alkaliphila sp. Nov. YIM-80379. Chem Biodivers
10:281–287. https://doi.org/10.1002/cbdv.201200086
125. Helaly SE, Goodfellow M, Zinecker H, Imhoff JF, Süssmuth RD, Fiedler HP (2013)
Warkmycin, a novel angucycline antibiotic produced by Streptomyces sp. Acta 2930.
J Antibiot (Tokyo) 66:669–674. https://www.nature.com/articles/ja20137
126. Jenifer A, Remya R, Velmurugan S, Michaelbabu M, Citarasu T (2018) Streptomyces
castaneoglobisporus AJ9, a haloalkaliphilic actinomycetes isolated from solar salt works in
southern India and its pharmacological properties. Indian J Mar Sci 47:475–488
127. Jonczyk E, Klak M, Miedzybrodzki R (2011) The influence of external factors on bacteriophages – a review. Folia Microbiol (Praha) 56:191–200
Metabolites Produced by Alkaliphiles with Potential Biotechnological. . .
193