14. Boger DL, Fecik RA, Patterson JE, Miyauchi H, Patricelli MP, Cravatt BF (2000) Fatty acid
amide hydrolase substrate specificity. Bioorg Med Chem Lett 10(23):2613–2616
15. Lichtman AH, Shelton CC, Advani T, Cravatt BF (2004) Mice lacking fatty acid amide
hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia. Pain 109(3):319–
327. doi:10.1016/j.pain.2004.01.022 S0304395904000545 [pii]
16. Clement AB, Hawkins EG, Lichtman AH, Cravatt BF (2003) Increased seizure susceptibility
and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase.
J Neurosci 23(9):3916–3923. doi:23/9/3916 [pii]
17. Cravatt BF, Lichtman AH (2003) Fatty acid amide hydrolase: an emerging therapeutic target in the
endocannabinoid system. Curr Opin Chem Biol 7(4):469–475. doi:S1367593103000796 [pii]
18. Cravatt BF, Demarest K, Patricelli MP, Bracey MH, Giang DK, Martin BR, Lichtman AH
(2001) Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in
mice lacking fatty acid amide hydrolase. Proc Natl Acad Sci USA 98(16):9371–9376. doi:10.
1073/pnas.161191698 161191698 [pii]
19. Wise LE, Shelton CC, Cravatt BF, Martin BR, Lichtman AH (2007) Assessment of
anandamide’s pharmacological effects in mice deficient of both fatty acid amide hydrolase and
cannabinoid CB1 receptors. Eur J Pharmacol 557(1):44–48. doi:10.1016/j.ejphar.2006.11.002
S0014-2999(06)01262-3 [pii]
20. Osei-Hyiaman D, Depetrillo M, Harvey-White J, Bannon AW, Cravatt BF, Kuhar MJ, Mackie
K, Palkovits M, Kunos G (2005) Cocaine- and amphetamine-related transcript is involved in
the orexigenic effect of endogenous anandamide. Neuroendocrinology 81(4):273–282. doi:10.
1159/000087925 87925 [pii]
21. Massa F, Marsicano G, Hermann H, Cannich A, Monory K, Cravatt BF, Ferri GL, Sibaev A,
Storr M, Lutz B (2004) The endogenous cannabinoid system protects against colonic
inflammation. J Clin Invest 113(8):1202–1209. doi:10.1172/JCI19465
22. Cravatt BF, Saghatelian A, Hawkins EG, Clement AB, Bracey MH, Lichtman AH (2004)
Functional disassociation of the central and peripheral fatty acid amide signaling systems. Proc
Natl Acad Sci USA 101(29):10821–10826. doi:10.1073/pnas.0401292101 0401292101 [pii]
23. Karsak M, Gaffal E, Date R, Wang-Eckhardt L, Rehnelt J, Petrosino S, Starowicz K, Steuder
R, Schlicker E, Cravatt B, Mechoulam R, Buettner R, Werner S, Di Marzo V, Tuting T,
Zimmer A (2007) Attenuation of allergic contact dermatitis through the endocannabinoid
system. Science 316(5830):1494–1497. doi:10.1126/science.1142265 316/5830/1494 [pii]
24. Naidu PS, Varvel SA, Ahn K, Cravatt BF, Martin BR, Lichtman AH (2007) Evaluation of
fatty acid amide hydrolase inhibition in murine models of emotionality. Psychopharmacology
192(1):61–70. doi:10.1007/s00213-006-0689-4
25. Moreira FA, Kaiser N, Monory K, Lutz B (2008) Reduced anxiety-like behaviour induced by
genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid
amide hydrolase (FAAH) is mediated by CB1 receptors. Neuropharmacology 54(1):141–150.
doi:10.1016/j.neuropharm.2007.07.005 S0028-3908(07)00214-6 [pii]
26. Huitron-Resendiz S, Sanchez-Alavez M, Wills DN, Cravatt BF, Henriksen SJ (2004)
Characterization of the sleep-wake patterns in mice lacking fatty acid amide hydrolase. Sleep
27(5):857–865
27. Varvel SA, Wise LE, Niyuhire F, Cravatt BF, Lichtman AH (2007) Inhibition of fatty-acid
amide hydrolase accelerates acquisition and extinction rates in a spatial memory task.
Neuropsychopharmacology 32(5):1032–1041. doi:10.1038/sj.npp.1301224 1301224 [pii]
28. Bambico FR, Cassano T, Dominguez-Lopez S, Katz N, Walker CD, Piomelli D, Gobbi G
(2010) Genetic deletion of fatty acid amide hydrolase alters emotional behavior and
serotonergic transmission in the dorsal raphe, prefrontal cortex, and hippocampus.
Neuropsychopharmacology 35(10):2083–2100. doi:10.1038/npp.2010.80
29. Gobbi G, Bambico FR, Mangieri R, Bortolato M, Campolongo P, Solinas M, Cassano T,
Morgese MG, Debonnel G, Duranti A, Tontini A, Tarzia G, Mor M, Trezza V, Goldberg SR,
Cuomo V, Piomelli D (2005) Antidepressant-like activity and modulation of brain
monoaminergic transmission by blockade of anandamide hydrolysis. Proc Natl Acad Sci
USA 102(51):18620–18625. doi:10.1073/pnas.0509591102 0509591102 [pii]
128
S.F. Sousa et al.
amide hydrolase substrate specificity. Bioorg Med Chem Lett 10(23):2613–2616
15. Lichtman AH, Shelton CC, Advani T, Cravatt BF (2004) Mice lacking fatty acid amide
hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia. Pain 109(3):319–
327. doi:10.1016/j.pain.2004.01.022 S0304395904000545 [pii]
16. Clement AB, Hawkins EG, Lichtman AH, Cravatt BF (2003) Increased seizure susceptibility
and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase.
J Neurosci 23(9):3916–3923. doi:23/9/3916 [pii]
17. Cravatt BF, Lichtman AH (2003) Fatty acid amide hydrolase: an emerging therapeutic target in the
endocannabinoid system. Curr Opin Chem Biol 7(4):469–475. doi:S1367593103000796 [pii]
18. Cravatt BF, Demarest K, Patricelli MP, Bracey MH, Giang DK, Martin BR, Lichtman AH
(2001) Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in
mice lacking fatty acid amide hydrolase. Proc Natl Acad Sci USA 98(16):9371–9376. doi:10.
1073/pnas.161191698 161191698 [pii]
19. Wise LE, Shelton CC, Cravatt BF, Martin BR, Lichtman AH (2007) Assessment of
anandamide’s pharmacological effects in mice deficient of both fatty acid amide hydrolase and
cannabinoid CB1 receptors. Eur J Pharmacol 557(1):44–48. doi:10.1016/j.ejphar.2006.11.002
S0014-2999(06)01262-3 [pii]
20. Osei-Hyiaman D, Depetrillo M, Harvey-White J, Bannon AW, Cravatt BF, Kuhar MJ, Mackie
K, Palkovits M, Kunos G (2005) Cocaine- and amphetamine-related transcript is involved in
the orexigenic effect of endogenous anandamide. Neuroendocrinology 81(4):273–282. doi:10.
1159/000087925 87925 [pii]
21. Massa F, Marsicano G, Hermann H, Cannich A, Monory K, Cravatt BF, Ferri GL, Sibaev A,
Storr M, Lutz B (2004) The endogenous cannabinoid system protects against colonic
inflammation. J Clin Invest 113(8):1202–1209. doi:10.1172/JCI19465
22. Cravatt BF, Saghatelian A, Hawkins EG, Clement AB, Bracey MH, Lichtman AH (2004)
Functional disassociation of the central and peripheral fatty acid amide signaling systems. Proc
Natl Acad Sci USA 101(29):10821–10826. doi:10.1073/pnas.0401292101 0401292101 [pii]
23. Karsak M, Gaffal E, Date R, Wang-Eckhardt L, Rehnelt J, Petrosino S, Starowicz K, Steuder
R, Schlicker E, Cravatt B, Mechoulam R, Buettner R, Werner S, Di Marzo V, Tuting T,
Zimmer A (2007) Attenuation of allergic contact dermatitis through the endocannabinoid
system. Science 316(5830):1494–1497. doi:10.1126/science.1142265 316/5830/1494 [pii]
24. Naidu PS, Varvel SA, Ahn K, Cravatt BF, Martin BR, Lichtman AH (2007) Evaluation of
fatty acid amide hydrolase inhibition in murine models of emotionality. Psychopharmacology
192(1):61–70. doi:10.1007/s00213-006-0689-4
25. Moreira FA, Kaiser N, Monory K, Lutz B (2008) Reduced anxiety-like behaviour induced by
genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid
amide hydrolase (FAAH) is mediated by CB1 receptors. Neuropharmacology 54(1):141–150.
doi:10.1016/j.neuropharm.2007.07.005 S0028-3908(07)00214-6 [pii]
26. Huitron-Resendiz S, Sanchez-Alavez M, Wills DN, Cravatt BF, Henriksen SJ (2004)
Characterization of the sleep-wake patterns in mice lacking fatty acid amide hydrolase. Sleep
27(5):857–865
27. Varvel SA, Wise LE, Niyuhire F, Cravatt BF, Lichtman AH (2007) Inhibition of fatty-acid
amide hydrolase accelerates acquisition and extinction rates in a spatial memory task.
Neuropsychopharmacology 32(5):1032–1041. doi:10.1038/sj.npp.1301224 1301224 [pii]
28. Bambico FR, Cassano T, Dominguez-Lopez S, Katz N, Walker CD, Piomelli D, Gobbi G
(2010) Genetic deletion of fatty acid amide hydrolase alters emotional behavior and
serotonergic transmission in the dorsal raphe, prefrontal cortex, and hippocampus.
Neuropsychopharmacology 35(10):2083–2100. doi:10.1038/npp.2010.80
29. Gobbi G, Bambico FR, Mangieri R, Bortolato M, Campolongo P, Solinas M, Cassano T,
Morgese MG, Debonnel G, Duranti A, Tontini A, Tarzia G, Mor M, Trezza V, Goldberg SR,
Cuomo V, Piomelli D (2005) Antidepressant-like activity and modulation of brain
monoaminergic transmission by blockade of anandamide hydrolysis. Proc Natl Acad Sci
USA 102(51):18620–18625. doi:10.1073/pnas.0509591102 0509591102 [pii]
128
S.F. Sousa et al.