reported for peptoids with 50 monomer units or less. This is, however, after
purification. For one-shot synthesis, a 50-mer is typically regarded as the limit to
retain reasonable yields [15]. However, what is considered a reasonable yield often
remains unclear.
Fig. 2 Comparison of a
selection of proteinogenic
amino acids and their
corresponding
N-substituted glycine
Fig. 3 Small selection of
peptoid side chains that
have been realized to date.
They may be used to direct
the adjacent amide bond
into either cis- or transconformation, introduce
charges along the peptoid
backbone, or modify
solubility of the peptoid
394
N. Gangloff and R. Luxenhofer