56
4
References
Berridge MJ (2012) Calcium signalling remodelling and disease. Biochem Soc Trans 40:297–309
Bichet D, Haass FA, Jan LY (2003) Merging functional studies with structures of inward-rectifier K(+) channels. Nat Rev Neurosci 4:957–967
Catterall WA (2000) From ionic currents to molecular mechanisms: the structure and function of voltagegated sodium channels. Neuron 26:13–25
Cestele S, Catterall WA (2000) Molecular mechanisms of neurotoxin action on voltage-gated sodium
channels. Biochimie 82:883–892
Civelli O (2012) Orphan GPCRs and neuromodulation. Neuron 76:12–21
Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B,
Sanguinetti MC, Stuhmer W, Wang X (2005) International Union of Pharmacology. LIII. Nomenclature
and molecular relationships of voltage-gated potassium channels. Pharmacol Rev 57:473–508
Huang W, Liu M, Yan SF, Yan N (2017) Structure-based assessment of disease-related mutations in human
voltage-gated sodium channels. Protein Cell 8:401–438
Isomoto S, Kondo C, Kurachi Y (1997) Inwardly rectifying potassium channels: their molecular heterogeneity and function. Jpn J Physiol 47:11–39
Labro AJ, Snyders DJ (2012) Being flexible: the voltage-controllable activation gate of kv channels. Front
Pharmacol 3:168
Li Q, Wanderling S, Paduch M, Medovoy D, Singharoy A, McGreevy R, Villalba-Galea CA, Hulse RE, Roux B,
Schulten K, Kossiakoff A, Perozo E (2014) Structural mechanism of voltage-dependent gating in an
isolated voltage-sensing domain. Nat Struct Mol Biol 21:244–252
Luscher C, Slesinger PA (2010) Emerging roles for G protein-gated inwardly rectifying potassium (GIRK)
channels in health and disease. Nat Rev Neurosci 11:301–315
Nozaki T, Ozawa SI, Harada H, Kimura T, Osawa M, Shimada I (2016) Disulfide mapping the voltage-sensing
mechanism of a voltage-dependent potassium channel. Sci Rep 6:37303
Nys M, Kesters D, Ulens C (2013) Structural insights into Cys-loop receptor function and ligand recognition. Biochem Pharmacol 86:1042–1053
Shen H, Zhou Q, Pan X, Li Z, Wu J, Yan N (2017) Structure of a eukaryotic voltage-gated sodium channel at
near-atomic resolution. Science 355:1
Skou JC, Esmann M (1992) The Na,K-ATPase. J Bioenerg Biomembr 24:249–261
Sokolova O, Kolmakova-Partensky L, Grigorieff N (2001) Three-dimensional structure of a voltage-gated
potassium channel at 2.5 nm resolution. Structure 9:215–220
Van Petegem F (2012) Ryanodine receptors: structure and function. J Biol Chem 287:31624–31632
Zalk R, Lehnart SE, Marks AR (2007) Modulation of the ryanodine receptor and intracellular calcium. Annu
Rev Biochem 76:367–385
Chapter 4 · Ion Channels
4
References
Berridge MJ (2012) Calcium signalling remodelling and disease. Biochem Soc Trans 40:297–309
Bichet D, Haass FA, Jan LY (2003) Merging functional studies with structures of inward-rectifier K(+) channels. Nat Rev Neurosci 4:957–967
Catterall WA (2000) From ionic currents to molecular mechanisms: the structure and function of voltagegated sodium channels. Neuron 26:13–25
Cestele S, Catterall WA (2000) Molecular mechanisms of neurotoxin action on voltage-gated sodium
channels. Biochimie 82:883–892
Civelli O (2012) Orphan GPCRs and neuromodulation. Neuron 76:12–21
Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B,
Sanguinetti MC, Stuhmer W, Wang X (2005) International Union of Pharmacology. LIII. Nomenclature
and molecular relationships of voltage-gated potassium channels. Pharmacol Rev 57:473–508
Huang W, Liu M, Yan SF, Yan N (2017) Structure-based assessment of disease-related mutations in human
voltage-gated sodium channels. Protein Cell 8:401–438
Isomoto S, Kondo C, Kurachi Y (1997) Inwardly rectifying potassium channels: their molecular heterogeneity and function. Jpn J Physiol 47:11–39
Labro AJ, Snyders DJ (2012) Being flexible: the voltage-controllable activation gate of kv channels. Front
Pharmacol 3:168
Li Q, Wanderling S, Paduch M, Medovoy D, Singharoy A, McGreevy R, Villalba-Galea CA, Hulse RE, Roux B,
Schulten K, Kossiakoff A, Perozo E (2014) Structural mechanism of voltage-dependent gating in an
isolated voltage-sensing domain. Nat Struct Mol Biol 21:244–252
Luscher C, Slesinger PA (2010) Emerging roles for G protein-gated inwardly rectifying potassium (GIRK)
channels in health and disease. Nat Rev Neurosci 11:301–315
Nozaki T, Ozawa SI, Harada H, Kimura T, Osawa M, Shimada I (2016) Disulfide mapping the voltage-sensing
mechanism of a voltage-dependent potassium channel. Sci Rep 6:37303
Nys M, Kesters D, Ulens C (2013) Structural insights into Cys-loop receptor function and ligand recognition. Biochem Pharmacol 86:1042–1053
Shen H, Zhou Q, Pan X, Li Z, Wu J, Yan N (2017) Structure of a eukaryotic voltage-gated sodium channel at
near-atomic resolution. Science 355:1
Skou JC, Esmann M (1992) The Na,K-ATPase. J Bioenerg Biomembr 24:249–261
Sokolova O, Kolmakova-Partensky L, Grigorieff N (2001) Three-dimensional structure of a voltage-gated
potassium channel at 2.5 nm resolution. Structure 9:215–220
Van Petegem F (2012) Ryanodine receptors: structure and function. J Biol Chem 287:31624–31632
Zalk R, Lehnart SE, Marks AR (2007) Modulation of the ryanodine receptor and intracellular calcium. Annu
Rev Biochem 76:367–385
Chapter 4 · Ion Channels